Published , Modified Abstract on Newly Discovered Infectious Prion Structure Shines Light on Mad Cow Disease Original source
Newly Discovered Infectious Prion Structure Shines Light on Mad Cow Disease
Mad cow disease, also known as bovine spongiform encephalopathy (BSE), is a fatal neurodegenerative disease that affects cattle. It can also be transmitted to humans through the consumption of infected meat, causing variant Creutzfeldt-Jakob disease (vCJD). For years, scientists have been studying the infectious agent responsible for these diseases, known as prions. Recently, a team of researchers has made a breakthrough discovery in understanding the structure of infectious prions.
What are Prions?
Prions are misfolded proteins that can cause other proteins to misfold and clump together, leading to the formation of plaques in the brain. These plaques can cause neurodegenerative diseases such as BSE and vCJD. Unlike viruses or bacteria, prions do not contain genetic material and are not alive in the traditional sense. They are highly resistant to heat, radiation, and disinfectants, making them difficult to destroy.
The Discovery
In 2016, researchers from the University of Texas at Austin and the National Institutes of Health (NIH) used a technique called cryo-electron microscopy (cryo-EM) to study the structure of infectious prions. They discovered that prions have a unique structure that allows them to convert normal proteins into misfolded ones.
The researchers found that infectious prions have a "corkscrew" shape made up of two intertwined protein molecules. This structure allows them to bind to normal proteins and convert them into misfolded ones. The researchers also found that the corkscrew shape is highly stable and resistant to heat and other environmental factors.
Implications for Mad Cow Disease
The discovery of the corkscrew-shaped prion structure has important implications for understanding how BSE and vCJD are transmitted. It suggests that the infectious prions can survive in the environment for long periods of time, even after the infected animal has been slaughtered and processed.
This discovery also opens up new avenues for developing treatments and preventative measures for prion diseases. By understanding the structure of infectious prions, scientists may be able to develop drugs that can target and destroy them.
Conclusion
The discovery of the corkscrew-shaped prion structure is a significant breakthrough in understanding the transmission and pathology of prion diseases such as BSE and vCJD. It provides new insights into how these diseases are transmitted and opens up new possibilities for developing treatments and preventative measures.
FAQs
1. What is mad cow disease?
Mad cow disease, also known as bovine spongiform encephalopathy (BSE), is a fatal neurodegenerative disease that affects cattle.
2. Can mad cow disease be transmitted to humans?
Yes, mad cow disease can be transmitted to humans through the consumption of infected meat, causing variant Creutzfeldt-Jakob disease (vCJD).
3. What are prions?
Prions are misfolded proteins that can cause other proteins to misfold and clump together, leading to the formation of plaques in the brain.
4. Why are prions difficult to destroy?
Prions are highly resistant to heat, radiation, and disinfectants, making them difficult to destroy.
5. What is cryo-electron microscopy?
Cryo-electron microscopy (cryo-EM) is a technique used to study the structure of molecules at near-atomic resolution by freezing them in a thin layer of ice and imaging them with an electron microscope.
This abstract is presented as an informational news item only and has not been reviewed by a subject matter professional. This abstract should not be considered medical advice. This abstract might have been generated by an artificial intelligence program. See TOS for details.
Most frequent words in this abstract:
disease (4),
prions (4),
infectious (3)