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Categories: Chemistry: Organic Chemistry, Environmental: Wildfires

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Researchers create a network of interacting proteins -- or interactome -- to aid drug discovery.

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RNAs can wreak havoc on cells if they aren't removed at the right time. Dis3L2 is a molecular 'machine' that untangles and chews up RNAs, but scientists have been unable to explain how. Biochemists have now pieced together the answer. By shape-shifting, the machine unsheathes a lethal wedge that pries open and chews up RNA molecules, a behavior previously unseen.

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Scientists recently announced the invention of a nanowire 10,000 times thinner than a human hair that can be cheaply grown by common bacteria and tuned to 'smell' a vast array of chemical tracers -- including those given off by people afflicted with a wide range of medical conditions, such as asthma and kidney disease. Thousands of these specially tuned wires, each sniffing out a different chemical, can be layered onto tiny, wearable sensors, allowing healthcare providers an unprecedented tool for monitoring potential health complications. Since these wires are grown by bacteria, they are organic, biodegradable and far greener than any inorganic nanowire.

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Scientists have used machine learning to create brand-new enzymes, which are proteins that accelerate chemical reactions. This is an important step in the field of protein design as new enzymes could have many uses across medicine and industrial manufacturing. The research team devised deep-learning, artificial intelligence algorithms that created light-emitting enzymes called luciferases. Laboratory testing confirmed that the new enzymes can recognize specific chemicals and emit light very efficiently.

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Researchers have developed principles and technologies of nanofluidic devices to freely manipulate nanomaterials, biomaterials, and molecules at the single-molecule level using fundamental technologies such as nanofluidic processing, functional integration, and fluidic control and measurement, which has pioneered the way to integrate various fields under nanofluidics. To elucidate the single molecule dynamics of chemical reactions in solution, using their unique nanofluidic devices, they outlined how they propose to solve problems such as precisely manipulating small molecules in solution and how to investigate extremely quick reactions, that only take nano- to picoseconds.

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Researchers created maps showing where warmer weather has left trees in conditions that don't suit them, making them more prone to being replaced by other species. The findings could help inform long-term wildfire and ecosystem management in these 'zombie forests.'

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The redox regulation mechanism responsible for efficient production of ATP under varying light conditions in photosynthetic organisms has now been unveiled. Researchers investigated the enzyme responsible for this mechanism and uncovered how the amino acid sequences present in the enzyme regulate ATP production. Their findings provide valuable insights into the process of photosynthesis and the ability to adapt to changing metabolic conditions.

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A new study brings this vision closer to reality. The researchers unveil a computational method for designing thousands of different active enzymes with unprecedented efficiency by assembling them from engineered modular building blocks.

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Scientists have figured out a way to engineer wood to trap carbon dioxide through a potentially scalable, energy-efficient process that also makes the material stronger for use in construction.

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Researchers have developed a machine learning-based ensemble approach to quantify fire-induced thaw settlement across the entire Tanana Flats in Alaska, which encompasses more than 3 million acres. They linked airborne repeat lidar data to time-series Landsat products (satellite images) to delineate thaw settlement patterns across six large fires that have occurred since 2000. The six fires resulted in a loss of nearly 99,000 acres of evergreen forest from 2000 to 2014 among nearly 155,000 acres of fire-influenced forests with varying degrees of burn severity. This novel approach helped to explain about 65 percent of the variance in lidar-detected elevation change.

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A new all-dry polymerization technique uses reactive vapors to create thin films with enhanced properties, such as mechanical strength, kinetics and morphology.

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Scientists have been using powerful computer models combined with laboratory experiments to study how a kind of clay can soak up carbon dioxide and store it.

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Excessive use of fossil fuels leads to undesired carbon dioxide (CO2) generation, accelerating climate change. One way to tackle this is by converting CO2 into value-added chemicals. On this front, researchers have recently utilized a novel redox couple, for the purpose.

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With a big assist from artificial intelligence and a heavy dose of human touch, a lab made a discovery that dramatically speeds up the time-consuming chemical process of building molecules that will be tomorrow's medicines, agrichemicals or materials.

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Hydrogen fuel could be a more viable alternative to traditional fossil fuels, according to University of Surrey researchers who have found that a type of metal-free catalysts could contribute to the development of cost-effective and sustainable hydrogen production technologies.

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The infamous spike proteins on the surface of SARS-CoV-2 help it bind to and enter human cells. Because of their important role in spreading infection, these spike proteins are one of the main targets for COVID-19 vaccines and treatments. But those remedies gradually lose effectiveness when certain segments of the spike proteins mutate. Now, researchers report that they have discovered small molecules that successfully target other segments that mutate less.

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A synthetic biosensor that mimics properties found in cell membranes and provides an electronic readout of activity could lead to a better understanding of cell biology, development of new drugs, and the creation of sensory organs on a chip capable of detecting chemicals, similar to how noses and tongues work.

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Researchers have used single carbon atom doping to form four chemical bonds in one step. Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression). The team chemically modified an anti-seizure medication in 96% yield, highlighting the work's utility to otherwise synthetically complex aspects of pharmaceutical development. The results of this work could become foundational to drug discovery and development.

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A research team examined what happens to mountain snowpacks when sunny, midwinter dry spells occur in forests impacted by severe wildfire.

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Between 2010 and 2020, human ignitions started 76% of the Western wildfires that destroyed structures, and those fires tended to be in flammable areas where buildings are increasingly common. Three times as many homes and other structures burned in these ten years than in the previous decade.