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Categories: Chemistry: Biochemistry, Physics: Acoustics and Ultrasound

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A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins. A new approach combines genetic association studies, gene editing, and single-cell sequencing to address these challenges and discover causal variants and genetic mechanisms for blood cell traits.

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An international team of researchers has developed a comprehensive manual for engineering spin dynamics in nanomagnets -- an important step toward advancing spintronic and quantum-information technologies.

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Researchers have developed an artificial intelligence system that can create proteins not found in nature using generative diffusion, the same technology behind popular image-creation platforms such as DALL-E and Midjourney.

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Storing data in DNA sounds like science fiction, yet it lies in the near future. Experts expect the first DNA data center to be up and running within five to ten years. Data won't be stored as zeros and ones in a hard drive but in the base pairs that make up DNA: AT and CG. Such a data center would take the form of a lab, many times smaller than the ones today.

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A new study has found links at the atomic level between photosynthesis and exciton condensates -- a strange state of physics that allows energy to flow frictionlessly through a material. The finding is scientifically intriguing and may suggest new ways to think about designing electronics, the authors said.

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All human beings are genetically very similar, sharing approx. 99.9% of the DNA code. The remaining 0.1% explains the natural differences between people, including our predisposition to hereditary diseases. Although sequencing of our genetic material is becoming a routine diagnostic analysis, it is unfortunately far from simple to determine whether specific small differences in our DNA affect our risk of developing disease. The usefulness of DNA sequencing is therefore often limited to the few cases where it is already known if a gene variant increases the risk of disease.

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A research group has succeeded in regulating the flow of single molecules in solution by opening and closing the nanovalve mounted on the nanofluidic device by applying external pressure. The research group fabricated a device with a ribbon-like, thin, soft glass sheet on the top, and at the bottom a hard glass substrate having nanochannels and nanovalve seats. By applying external pressure to the soft glass sheet to open and close the valve, they succeeded in directly manipulating and controlling the flow of individual molecules in solution. They also observed an effect of fluorescence signal amplification when single fluorescent molecules are confined in the tiny nanospace inside the valve. The effect can be ascribed to the nanoconfinement, which suppresses the random motion of the molecules.

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If you're a fan of arts and crafts, you're likely familiar with the messy, sticky, frustration-inducing nature of liquid glues. But researchers now have a brand-new way to weld squishy stuff together without the need for glue at all. They've demonstrated a universal, 'electroadhesion' technique that can adhere soft materials to each other just by running electricity through them.

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In a world hungry for clean energy, engineers have created a new material that converts the simple mechanical vibrations all around us into electricity to power sensors in everything from pacemakers to spacecraft.

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Scientists have developed a new extraction protocol for RNA-seq and metabolomic analysis, offering a more complete picture of cellular activity than either technique on its own. The protocol employs a streamlined extraction from a single sample, which reduces variation, improves efficiency, preserves data fidelity and maximizes use of precious biospecimens.

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Engineers have developed a stretchable ultrasonic array capable of serial, non-invasive, three-dimensional imaging of tissues as deep as four centimeters below the surface of human skin, at a spatial resolution of 0.5 millimeters. This new method provides a non-invasive, longer-term alternative to current methods, with improved penetration depth.

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New research shows that artificial intelligence (AI) systems can process signals in a way that is remarkably similar to how the brain interprets speech, a finding scientists say might help explain the black box of how AI systems operate.

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A lab has developed a deep neural network that improves the accuracy of their unique devices for detecting pathogen biomarkers.

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Scientists have harnessed chemical reactions to make microscale origami machines self-fold -- freeing them from the liquids in which they usually function, so they can operate in dry environments and at room temperature.

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Using a "spooky" phenomenon of quantum physics, researchers have discovered a way to double the resolution of light microscopes.

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By connecting small self-propelling toys in a chain, researchers have found the key to studying the movement of microscopic organisms and molecular motors inside our cells.

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Couches, tables, sleeves and more can turn into a high-fidelity input device for computers using a new sensing system.

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The mechanics behind the collapse of soft materials structure have befuddled researchers for decades. In a new study, researchers uncover a metric that finally correlates microscopic-level processes with what is seen at the macroscopic level.

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Researchers have discovered that the electrical fields and activity that exist through a cell's membrane also exist within and around another type of cellular structure called biological condensates. Like oil droplets floating in water, these structures exist because of differences in density. Their foundational discovery could change the way researchers think about biological chemistry. It could also provide a clue as to how the first life on Earth harnessed the energy needed to arise.

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A machine-learning method detects internal structures, voids, and cracks inside a material, based on data about the material's surface.