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Categories: Biology: Developmental, Geoscience: Landslides

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Researchers hope that a new, publicly available database they have created will shrink, not grow, over time. That's because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, whose existence is known but whose functions are mostly not.

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Tumor cells are known to be fickle sleeper agents, often lying dormant in distant tissues for years before reactivating and forming metastasis. Numerous factors have been studied to understand why the activation occurs, from cells and molecules to other components in the so-called tissue microenvironment.

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Bacteria make up more than 10% of all living things but until recently we had little realization that, as in humans, soil bacteria have internal clocks that synchronize their activities with the 24-hour cycles of day and night on Earth. New research shows just how complex and sophisticated these bacterial circadian clocks are, clearing the way for an exciting new phase of study.

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Researchers have discovered a previously unknown mechanism by which bacteria share their genetic material through virus parasites. The insights could help scientists to better understand how bacteria rapidly adapt and evolve, and how they become more virulent and resistant to antibiotics.

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The immune regulatory protein STING has a previously unknown function: acting as an ion channel that allows protons to leak into cells. This discovery makes it the first human immune sensor that can translate danger signals into ion flow.

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Researchers have changed the way to look at DNA. They show that DNA is much more than a linear sequence of building blocks; it has a 3D structure that influences the variation of human genome-wide mutation rates meaningfully and consistently, and this is likely conserved among species.

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A team of scientists has made an important breakthrough in the fight against RNA viruses that cause human diseases and pandemics.

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In a breakthrough for bioengineering, researchers have developed organoids that can model the human respiratory tract. The organoids, called AirGels, allow them to uncover the mechanism by which antibiotic-resistant pathogens like Pseudomonas aeruginosa infect the respiratory tract.

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Researchers have discovered new cell types in the visual system of flies, made possible by their creation of a tool that finds and labels neurons during development. The study combines single-cell sequencing data with a novel algorithm to identify pairs of genes that point to previously unknown cells in the brains of fruit flies.

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Scientists have pinpointed a genetic cause for virgin birth for the first time, and once switched on the ability is passed down through generations of females.

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Originally, the powerhouses of higher cells, the mitochondria, were independent organisms. Researchers have investigated to what extent their metabolism has blended with that of their host cells in the course of evolution, using the example of a mitochondrial stress response. They have discovered that mitochondria send two different biochemical signals. These are processed together in the cell and trigger a support mechanism to restore cellular balance (homeostasis).

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A metabolic by-product that is more prevalent during fasting may supercharge immune cells as they fight infection and disease, reports an early stage study. The findings may pave the way for future personalized dietary recommendations to augment treatments for infection, cancer and other diseases.

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Bees and wasps have converged on the same architectural solutions to nest-building problems, according to new research.

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In a step forward in the development of genetic medicines, researchers have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body. If translated into the clinic, this approach could expand access and reduce the cost of gene therapies for blood disorders, many of which currently require patients receive chemotherapy and a stem cell transplant.

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What happens inside the carnivorous plant Venus Flytrap when it catches an insect? New technology has led to discoveries about the electrical signalling that causes the trap to snap shut. Bioelectronic technology enables advanced research into how plants react to their surroundings, and to stress.

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The lifespan of a small roundworm that has been used as a key model organism in aging research is limited by how it self-sacrifices to feed its young, finds a new study.

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The results of a novel study has revealed exciting findings in the pursuit of an HIV cure.

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Researchers have identified a genetic sequence that is essential for plant reproduction. As this region is found in all plant species, it is expected to contribute to future crossbreeding initiatives and help solve the important problem of seed formation defects.

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Researchers find large methane emissions: 'Do not flood low-lying areas with freshwater'. Their studies find that freshwater lakes emit much more methane than saltwater lagoons, bogs and wet meadows.

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Scientists once assumed that flooding and mudslides after wildfires were linked to the waxy coating that builds up on charred soil, preventing water absorption. Researchers found that water flow came from absorbed water in both burnt and unburnt areas, suggesting that water was, in fact, being absorbed into burnt ground. The discovery provides valuable insights into where and when potential flooding and mudslides may occur and how landscapes recover after a wildfire.