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Categories: Biology: Genetics
Published New genetic test will eliminate a form of inherited blindness in dogs
(via sciencedaily.com) Original source Scientists have identified the genetic mutation that causes progressive retinal atrophy in English Shepherd Dogs, which results in incurable blindness, and developed a genetic test to help eliminate the disease from future generations of the breed.
Published Exposing dengue's invasion strategies
(via sciencedaily.com) Original source Mosquito-borne viral infections once confined to tropical regions are spreading. Dengue virus infects up to 400 million people worldwide each year according to World Health Organization estimates, and no available treatments exist for this disease. Now, research uncovered surprising strategies for how dengue and hundreds of other viruses replicate in their hosts, with the potential to aid in developing novel antiviral treatments and vaccines.
Published Controlling mosquito populations through genetic breeding
(via sciencedaily.com) Original source Researchers have found a new way to identify genetic targets useful for control of mosquito populations, potentially offering an alternative to insecticides. Their study focused on the genetic basis of species incompatibility. They crossed Ae. aegypti, a major global arboviral disease vector, and its sibling species, Ae. mascarensis, from the Indian Ocean. When offspring is crossed back with one parent, about 10 percent of the progeny becomes intersex and is unable to reproduce.
Published Not everything that tastes bitter is potentially harmful: But why? Study provides an explanation
(via sciencedaily.com) Original source A bitter taste is traditionally considered a warning sign of potentially toxic substances. But not all bitter substances are harmful. For example, some peptides and free amino acids taste bitter, even though they are non-toxic, nutritious and sometimes even vital for humans. A new study now offers an explanation for this seemingly paradoxical phenomenon.
Published Transient structure in fly leg holds clue to insect shape formation
(via sciencedaily.com) Original source A little leg may reveal something big about how closely related insect species can drastically differ in body shape, according to a new study. The team imaged live cells of fruit flies in the last stages of development over several days and found a new structure that appears to help guide a section of the leg into its final shape.
Published Genome study informs restoration of American chestnut tree
(via sciencedaily.com) Original source Researchers use genomes to help restore the American chestnut population and adjust species breeding to the changing climate.
Published The rhythm led by plants is crucial for symbiosis with nutrient-providing bacteria
(via sciencedaily.com) Original source Recent research on Lotus japonicus, a model leguminous plant, has unveiled that the interaction between legume roots and rhizobia is characterized by periodic gene expression with a six-hour rhythm. This rhythmic gene expression influences the regions of the root susceptible to rhizobial infection and the distribution of nodules. It was also discovered that the plant hormone cytokinin is crucial for maintaining this gene expression rhythm.
Published Small animals acquire genes from bacteria that can produce antibiotics
(via sciencedaily.com) Original source A group of small, freshwater animals (bdelloid rotifers) protect themselves from infections using antibiotic recipes 'stolen' from bacteria, according to new research. This raises the potential that rotifers are producing novel antimicrobials that may be less toxic to animals, including humans, than those we develop from bacteria and fungi.
Published Secrets behind viral precision
(via sciencedaily.com) Original source New research is shedding light on how viruses ensure their survival by precisely timing the release of new viruses. The discovery offers a new theoretical framework for understanding these dynamic biological phenomena.
Published Ancient viruses fuel modern-day cancers
(via sciencedaily.com) Original source The human genome is filled with flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago. Scientists used to think they were harmless, but new research shows that, when reawakened, they help cancer survive and thrive.
Published Discovery of a hybrid lineage offers clues to how trees adapt to climate change
(via sciencedaily.com) Original source The discovery of a hybrid population of poplar trees in western Wyoming has provided insight into how natural hybridization informs the evolution of many plant species, according to researchers. They also said their discovery suggests that genetic exchange between species may be critical for adaptation to environmental change.
Published Paleolithic diets are not without risks
(via sciencedaily.com) Original source High-protein diets, known as 'Paleolithic diets', are popular. Using mouse models, scientists have studied their impact. While effective in regulating weight and stabilizing diabetes, these diets are not without risks. Excess protein greatly increases ammonium production, overwhelming the liver. Excess ammonium can cause neurological disorders and, in severe cases, lead to coma. These results suggest caution when following these diets.
Published Genome recording makes living cells their own historians
(via sciencedaily.com) Original source Genomes can now be used to store information about a variety of transient biological events inside of living cells, as they happen, like a flight recorder collecting data from an aircraft. The method, called ENGRAM, aims to turn cells into their own historians. ENGRAM couples each kind of biological signal or event inside a cell to a symbolic barcode. This new strategy traces and archives the type and timing of biological signals inside the cell by inserting this information into the genome. For example, this record-keeping can track the commands that turn genes on or off.
Published Influenza viruses can use two ways to infect cells
(via sciencedaily.com) Original source Most influenza viruses enter human or animal cells through specific pathways on the cells' surface. Researchers have now discovered that certain human flu viruses and avian flu viruses can also use a second entry pathway, a protein complex of the immune system, to infect cells. This ability helps the viruses infect different species -- and potentially jump between animals and humans.
Published A new addition to the CRISPR toolbox: Teaching the gene scissors to detect RNA
(via sciencedaily.com) Original source CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers have now expanded this extensive toolbox further. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy.
Published Unique characteristics of previously unexplored protein discovered
(via sciencedaily.com) Original source Research achieves scientific breakthrough in understanding cell division.
Published Immune system in the spotlight
(via sciencedaily.com) Original source Our immune system is always on alert, detecting and eliminating pathogens and cancer cells. Cellular control mechanisms cause diseased cells to present antigens on their surface like signs for the immune system. For analysis of the necessary complex antigen processing and transport processes in real time, researchers have developed a 'cage' that is opened with light to release trapped antigens at a specific place and time.
Published Ancient microbes offer clues to how complex life evolved
(via sciencedaily.com) Original source Researchers have discovered that a single-celled organism, a close relative of animals, harbors the remnants of ancient giant viruses woven into its own genetic code. This finding sheds light on how complex organisms may have acquired some of their genes and highlights the dynamic interplay between viruses and their hosts.
Published E. coli variant may cause antimicrobial resistance in dogs, humans
(via sciencedaily.com) Original source Researchers studying antimicrobial-resistant E. coli -- the leading cause of human death due to antimicrobial resistance worldwide -- have identified a mechanism in dogs that may render multiple antibiotic classes ineffective.
Published Building a roadmap to bioengineer plants that produce their own nitrogen fertilizer
(via sciencedaily.com) Original source Nitrogen fertilizers make it possible to feed the world's growing population, but they are also costly adn harm ecosystems. However, a few plants have evolved the ability to acquire their own nitrogen with the help of bacteria, and a new study helps explain how they did it, not once, but multiple times.