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Categories: Biology: Evolutionary, Mathematics: Statistics

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Scientists have deciphered a comprehensive, continuous genome for a parasite responsible for transmitting Lyme disease and other serious infections to hundreds of thousands of Americans yearly. With their newly described genome for the black-legged tick, or deer tick, the researchers identified thousands of novel genes and new protein functions, including proteins associated with tick immunity, disease transmission and developmental stages.

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Synthetic populations are computer-generated models that mimic real-world populations in terms of characteristics such as age, gender, and occupation; they are useful when conducting social simulations. In a recent study, researchers developed a new approach to assign workplaces to individuals in a synthetic Japanese population with household information, based on ODI (Origin-Destination-Industry) data. Their efforts will enable more accurate, realistic simulations of the day-time distribution of workers in Japan, helping to improve decision-making and planning.

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Madagascar is home to a unique biodiversity with a large number of endemic species, among those many lemur species, including the mouse lemurs. This diversity is also found in their retroviruses. Biologists analyzed the mouse lemur genome and identified viruses of two classes that represent ancient infections of the mouse lemur germline. The viruses now behave similarly to lemur genes and are thus called endogenous retroviruses (ERVs). It was surprising that some of the identified retroviruses are closely related to viruses found in other, very different mammals such as polar bears or domestic sheep. This suggests an intriguing and complex pattern of host switching of retroviruses, much more complex than previously thought.

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The crocodilian edition of hemoglobins -- the scuba tanks of the blood -- work so well that crocs can go hours without air. The hyper-efficiency of that adaptation has led some biologists to wonder why, of all the jawed vertebrates, crocodilians were the lone group to hit on such an optimal solution to making the most of a breath. After resurrecting the hemoglobin of ancient crocodilian ancestors, a team may have an answer.

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Researchers describe five new deep-sea squat lobster species. Combining molecular data and microCT their findings show a wider species distribution range and shallower genetic diversity, calling for a revision of the current classification of squat lobsters.

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90% of the plants and animals on Madagascar are found nowhere else on Earth, but this treasure trove of evolution is under serious threat due to habitat loss, over-hunting, and climate change. In this study, researchers examined how long it took Madagascar's unique modern mammal species to emerge and estimated how long it would take for a similarly complex set of new mammal species to evolve in their place if the endangered ones went extinct: 23 million years, far longer than scientists have found for any other island.

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All chlamydiae today live inside the cells of hosts ranging from amoeba to animals. A team of scientists found that the ancestor of chlamydiae likely already lived inside host cells, but that chlamydiae infecting amoeba evolved later in ways unexpected for intracellular bacteria. The study is an important step for understanding the emergence and evolution of endosymbiotic bacteria, including human pathogens.

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Lizards living in different cities have parallel genomic markers when compared to neighboring forest lizards, according to a new study. The genetic variations linked to urbanization underlie physical differences in the urban lizards, including longer limbs and larger toe pads that show how these lizards have evolved to adapt to city environments.

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Smallpox was once one of humanity's most devastating diseases, but its origin is shrouded in mystery. For years, scientific estimates of when the smallpox virus first emerged have been at odds with historical records. Now, a new study reveals that the virus dates back 2,000 years further than scientists have previously shown, verifying historical sources and confirming for the first time that the disease has plagued human societies since ancient times.

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What genetic changes are responsible for the evolution of phenotypic traits? This question is not always easy to answer. A newly developed method now makes the search much easier.

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A new paper presents a mathematical model for the motion of bacteria that includes cell division and death, the basic ingredients of the cell cycle.

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A new study shows machine-learning models trained using simple symptoms, demographic features are effective in predicting COVID-19 infections.

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A new statistical method provides a more efficient way to uncover biologically meaningful changes in genomic data that span multiple conditions -- such as cell types or tissues.

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America was unprepared for the magnitude of the pandemic, which overwhelmed many counties and filled some hospitals to capacity. A new study suggests there may have been a mathematical method, of sorts, to the madness of those early COVID days.

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People often wonder why one nutritional study tells them that eating too many eggs, for instance, will lead to heart disease and another tells them the opposite. The answer to this and other conflicting food studies may lie in the use of statistics, according to a new report.

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Researchers followed the birth and death of tens of thousands of nematode worms using the 'Lifespan Machine', which collects lifespan data at unprecedented statistical resolution. They found that worms have at least two distinct 'biological ages', and that these have consistent correlations between each other, suggesting the existence of an invisible hierarchical structure that regulates the ageing process. The findings challenge the idea of living organisms having a single, universal biological age. It also means mean that biomarkers used to assess biological age can be changed by interventions such as diet, exercise, or drug treatments without actually turning a 'fast ager' into a 'slow ager'. The study calls into question the use of ageing biomarkers -- what exactly are they measuring?

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The contact.engineering platform enables users to create a digital twin of a surface and thus to help predict, for example, how quickly it wears out, how well it conducts heat, or how well it adheres to other materials.

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A commentary advocates the proper application of artificial intelligence in healthcare and warns of the dangers when machine learning algorithms are misused.

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Scientists have developed a method to identify symmetries in multi-dimensional data using Bayesian statistical techniques. Bayesian statistics has been in the spotlight in recent years due to improvements in computer performance and its potential applications in artificial intelligence. However, this statistical approach requires complex calculations of integrals, which are often considered approximations only. In their new study, the research team successfully derived new exact integral formulas. Their findings contribute to improving the accuracy of methods to identify data symmetries, possibly extending their applications to wider areas of interest, such as genetic analysis.

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A groundbreaking Bayesian method and new statistical analyses of genomic data from geckos in the Philippines shows that during the ice ages, the timing of gecko diversification gives strong statistical support for the first time to the Pleistocene aggregate island complex (PAIC) model of diversification, or 'species pump.'