Showing 20 articles starting at article 161
< Previous 20 articles Next 20 articles >
Categories: Biology: Molecular
Published Heating proteins to body temperature reveals new drug targets
(via sciencedaily.com) Original source Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications. The findings could revolutionize wide swathes of biology by fundamentally changing how protein structure is studied and leveraged for drug design.
Published Now we know, what gets roots to grow: Can help in future droughts
(via sciencedaily.com) Original source A biological mechanism familiar to people who fast helps plant roots grow strong. The discovery provides an answer to a long-unanswered question and a deeper understanding of the 'mouths' of plants that can help to develop climate-resilient crops.
Published An active agent against hepatitis E
(via sciencedaily.com) Original source At present, there is no specific active substance against hepatitis E. As the disease kills 70,000 people every year, researchers are actively searching for one. A team may have found what they're looking for. The researchers showed that the compound K11777 prevents host cells from helping the virus out of its shell by cleaving the viral capsid. This means it can no longer infect cells.
Published Exploring the mechanism behind drug eruptions in the skin
(via sciencedaily.com) Original source Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used genetically engineered mice to demonstrate the role of HLA in mediating intracellular reactions in keratinocytes, leading to drug eruptions in the skin. Their findings could lead to improved preventive and treatment measures for drug eruptions.
Published Drug compounds to combat neurodegenerative diseases
(via sciencedaily.com) Original source Prions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal cellular proteins. Prion disease is an umbrella term for a group of fatal and currently untreatable neurodegenerative diseases that not only affect humans, but also wild and captive animals. These diseases include Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE, or 'mad cow disease'), and chronic wasting disease (CWD) affecting deer, elk and moose.
Published Some mice may owe their monogamy to a newly evolved type of cell
(via sciencedaily.com) Original source What makes the oldfield mouse steadfastly monogamous throughout its life while its closest rodent relatives are promiscuous? The answer may be a previously unknown hormone-generating cell. Scientists discover the cells and hormones that inspire mice to nurture their young; the same hormones are also present in humans.
Published Far from toxic, lactate rivals glucose as body's major fuel after a carbohydrate meal
(via sciencedaily.com) Original source Scientists have documented the benefits of lactate burning in exercising humans, but few studies have looked at the role of lactate during rest or after a meal. Exercise physiologists challenged fasting men and women with a carbohydrate meal and then monitored lactate in the blood and fat vs carbohydrate metabolism. They found that lactate buffers glucose from a meal, and that lactate is utilized for energy almost as much as glucose.
Published Insights into protein evolution
(via sciencedaily.com) Original source A research team has unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve.
Published Fruit fly testes offer potential tool against harmful insects
(via sciencedaily.com) Original source A way to curb nagging insects has been flying under our radar -- an enzyme from fruit fly testes. The compound could control bugs that carry disease and harm crops by stunting their ability to procreate, researchers have found.
Published Like dad and like mum ... all in one plant
(via sciencedaily.com) Original source Scientists have established a system to generate clonal sex cells in tomato plants and used them to design the genomes of offspring. The fertilization of a clonal egg from one parent by a clonal sperm from another parent led to plants containing the complete genetic information of both parents.
Published New molecule mimics the anti-clotting action of blood-sucking organisms
(via sciencedaily.com) Original source Nature gave ticks, mosquitoes and leaches a quick-acting way to keep blood from clotting while they extract their meal from a host. Now the key to that method has been harnessed by a team of researchers as a potential anti-clotting agent that could be used as an alternative to heparin during angioplasty, dialysis care, surgeries and other procedures.
Published Research on centromere structure yields new insights into the mechanisms of chromosome segregation errors
(via sciencedaily.com) Original source Researchers have made a surprising new discovery in the structure of the centromere, a structure that is involved in ensuring that chromosomes are segregated properly when a cell divides. Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important implications for the process of chromosome segregation and provides new mechanisms underlying erroneous divisions in cancer cells. The research was published in Cell on May 13th 2024.
Published How do genetically identical water fleas develop into male or female?
(via sciencedaily.com) Original source Researchers have used a novel combination of short-read and long-read RNA sequencing to identify the different isoforms of genes expressed in the crustacean Daphnia magna. Males and females are genetically identical, but using this technique the team revealed genes that switch the predominant isoform in a male-female-dependent manner. This study may help further advance technologies in crustacean aquaculture.
Published Research shows that 'softer' proteins can cross into the nucleus quicker
(via sciencedaily.com) Original source Researchers have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus.
Published Cellular activity hints that recycling is in our DNA
(via sciencedaily.com) Original source Introns are perhaps one of our genome's biggest mysteries. They are DNA sequences that interrupt the sensible protein-coding information in your genes, and need to be 'spliced out.'
Published Scientists unlock key to breeding 'carbon gobbling' plants with a major appetite
(via sciencedaily.com) Original source The discovery of how a critical enzyme 'hidden in nature's blueprint' works sheds new light on how cells control key processes in carbon fixation, a process fundamental for life on Earth. The discovery could help engineer climate resilient crops capable of sucking carbon dioxide from the atmosphere more efficiently, helping to produce more food in the process.
Published New sex-determining mechanism in African butterfly discovered
(via sciencedaily.com) Original source In a study of a species of African butterfly, researchers have discovered a previously undescribed molecular mechanism of how the sex of an embryo is initially specified.
Published Fruit fly model identifies key regulators behind organ development
(via sciencedaily.com) Original source A new computational model simulating fruit fly wing development has enabled researchers to identify previously hidden mechanisms behind organ generation. An research team developed a fruit fly model to reverse engineer the mechanisms that generate organ tissue.
Published Progression of herpesvirus infection remodels mitochondrial organization and metabolism
(via sciencedaily.com) Original source Researchers have found that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell. The new information will help to understand the interaction between herpesvirus and host cells. Knowledge can be utilized in the development of viral treatments.
Published How a 'conductor' makes sense of chaos in early mouse embryos
(via sciencedaily.com) Original source The earliest stages of mammalian embryo development are like an orchestra performance, where everyone must play at the exact right moment and in perfect harmony. New research identifies one of the conductors making sense of the chaos.