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Categories: Biology: Microbiology, Physics: Quantum Computing
Published Gut microbiome can increase risk, severity of HIV, EBV disease
(via sciencedaily.com) Original source Researchers created a germ-free mouse model to evaluate the role of the microbiome in the infection, replication, and pathogenesis of HIV and the Epstein-Barr virus, the virus that can cause mononucleosis and other serious diseases.
Published Potential application of unwanted electronic noise in semiconductors
(via sciencedaily.com) Random telegraph noise (RTN) in semiconductors is typically caused by two-state defects. Two-dimensional (2D) van der Waals (vdW) layered magnetic materials are expected to exhibit large fluctuations due to long-range Coulomb interaction; importantly, which could be controlled by a voltage compared to 3D counterparts having large charge screening. Researchers reported electrically tunable magnetic fluctuations and RTN signal in multilayered vanadium-doped tungsten diselenide (WSe2) by using vertical magnetic tunneling junction devices. They identified bistable magnetic states in the 1/f2 RTNs in noise spectroscopy, which can be further utilized for switching devices via voltage polarity.
Published Common cold virus linked to potentially fatal blood clotting disorder
(via sciencedaily.com) Original source A new observation suggests that a life-threatening blood clotting disorder can be caused by an infection with adenovirus, one of the most common respiratory viruses in pediatric and adult patients.
Published Researchers find new pathway for HIV invasion of cell nucleus
(via sciencedaily.com) Original source A study has identified a new pathway that human immune deficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells.
Published Gastrointestinal viruses all but disappeared during COVID -- but surged back two years on
(via sciencedaily.com) Original source Following the first stay-at-home orders issued in the U.S. to curb the spread of COVID-19, gastrointestinal viruses such as norovirus, rotavirus and adenovirus all but disappeared from California communities, and remained at very low levels for nearly 2 years, according to new research.
Published Synthetic antibiotic could be effective against drug-resistant superbugs
(via sciencedaily.com) Original source A scientific journey decades in the making has found a new antibiotic strategy to defeat gram-negative bacteria like Salmonella, Pseudomonas and E. coli, the culprits in many urinary tract infections. The synthetic molecule works fast and is durable. It interferes with synthesis of the bacterial outer membrane by jamming an enzyme. When tested against a clinical collection of 285 bacterial strains, including some that were highly resistant to commercial antibiotics, it killed them all.
Published Sugars in breastmilk could help treat infections, prevent preterm births
(via sciencedaily.com) Original source Breastfeeding has long been used as a method to help keep newborns healthy and protected against a variety of diseases. But certain sugars naturally found in breastmilk could also help prevent infections before a baby arrives. Researchers have found that these sugars can stop a common prenatal infection in human tissues and pregnant mice. This could someday help people avoid preterm births or complications without the need for additional antibiotics.
Published Molnupiravir administered at human effect size-equivalent dose blocks SARS-CoV-2 transmission in ferrets, researchers find
(via sciencedaily.com) Original source Two oral drugs, molnupiravir and paxlovid (nirmatrelvir/ritonavir), provide equivalent therapeutic benefit in preventing severe COVID-19 in animal models, but only molnupiravir efficiently blocked SARS-CoV-2 transmission when administered at a human effect size-equivalent dose, according to a new study.
Published Treatments for poxviruses -- including those causing mpox and smallpox -- may already exist in licensed drugs
(via sciencedaily.com) Original source The drug tecovirimat is currently in use for the treatment of mpox -- the disease caused by monkeypox virus -- that spread worldwide in 2022. Tecovirimat is an anti-poxviral drug, and its use is driving the emergence of drug-resistant variants of the monkeypox virus. Scientists have identified how monkeypox virus exploits a cellular protein to evade host defenses, allowing it to replicate and spread better. Existing drugs -- developed to treat other viral infections -- also target this cellular protein. When tested against a range of poxviruses, including monkeypox, these drugs were found to have antiviral effects in all cases.
Published Researchers use SPAD detector to achieve 3D quantum ghost imaging
(via sciencedaily.com) Researchers have reported the first 3D measurements acquired with quantum ghost imaging. The new technique enables 3D imaging on a single photon level, yielding the lowest photon dose possible for any measurement.
Published Quantum material exhibits 'non-local' behavior that mimics brain function
(via sciencedaily.com) New research shows that electrical stimuli passed between neighboring electrodes can also affect non-neighboring electrodes. Known as non-locality, this discovery is a crucial milestone toward creating brain-like computers with minimal energy requirements.
Published Remission from HIV-1 infection: Discovery of broadly neutralizing antibodies that contribute to virus control
(via sciencedaily.com) Original source Some HIV-1 carriers who have received an early antiretroviral treatment during several years are able to control the virus for a long term after treatment interruption. However, the mechanisms enabling this post-treatment control have not been fully elucidated. Scientists have now investigated and revealed how neutralizing antibodies, including those described as broadly neutralizing, contribute to virus control. A clinical trial involving the use of broadly neutralizing antibodies should begin in France before the end of 2023.
Published Potential novel breakthrough treatment for fungal infections
(via sciencedaily.com) Original source Fungal infections are killing thousands of Americans each year, some with a morbidity rate of nearly 80%. To make matters worse, only a handful of antifungal treatments are available, and even those are becoming less effective as fungi become more resistant. However, researchers recently published findings indicating that a novel breakthrough treatment may have been discovered.
Published How the Epstein-Barr virus transforms B cells
(via sciencedaily.com) Original source Epstein-Barr virus (EBV) infection is known to convert resting B lymphocytes into immortal cells that continuously multiply, leading to posttransplant lymphoproliferative disorder (PTLD). Researchers have now uncovered the molecular mechanisms of this growth transformation, demonstrating the crucial role of the cancer-related gene IMPDH2 and nucleolar enlargement. Additionally, the research revealed strong evidence supporting the efficacy of mycophenolate mofetil, an approved immunosuppressant, in inhibiting PTLD, highlighting its therapeutic significance.
Published Astonishing complexity of bacterial circadian clocks
(via sciencedaily.com) Original source Bacteria make up more than 10% of all living things but until recently we had little realization that, as in humans, soil bacteria have internal clocks that synchronize their activities with the 24-hour cycles of day and night on Earth. New research shows just how complex and sophisticated these bacterial circadian clocks are, clearing the way for an exciting new phase of study.
Published Parasites of viruses drive superbug evolution
(via sciencedaily.com) Original source Researchers have discovered a previously unknown mechanism by which bacteria share their genetic material through virus parasites. The insights could help scientists to better understand how bacteria rapidly adapt and evolve, and how they become more virulent and resistant to antibiotics.
Published How the hospital pathogen Acinetobacter baumannii quickly adapts to new environmental conditions
(via sciencedaily.com) Original source Hospital-acquired infections are often hard to treat because the corresponding pathogens become increasingly resistant against antibiotics. The bacterium Acinetobacter baumannii is particularly feared, and there is great pressure to devise novel therapeutic approaches to combat it. Bioinformaticians have now detected an unexpectedly wide diversity of certain cell appendages in A. baumannii that are associated with pathogenicity. This could lead to treatment strategies that are specifically tailored to a particular pathogen.
Published Influenza shows no seasonality in tropics, posing challenges for health care
(via sciencedaily.com) Original source In temperate climates, like North America and Europe, flu season starts in the fall, peaks in the winter and ends in the spring. While public health officials have generally assumed that influenza is also seasonal in tropical climates, new research has found little evidence of a repeatable pattern in influenza cases in Vietnam. The findings suggest that influenza is likely unpredictable throughout the tropics, posing substantial challenges for prevention and management of cases for the one-third of the global population living in tropical areas.
Published Current takes a surprising path in quantum material
(via sciencedaily.com) Researchers used magnetic imaging to obtain the first direct visualization of how electrons flow in a special type of insulator, and by doing so they discovered that the transport current moves through the interior of the material, rather than at the edges, as scientists had long assumed.
Published Unleashing a new era of color tunable nano-devices -- smallest ever light source with switchable colors formed
(via sciencedaily.com) New research has achieved a significant breakthrough in color switching for nanocrystals, unlocking exciting possibilities for a simple, energy efficient display design and for tunable light sources needed in numerous technologies. The discovery also has potential applications in sensitive sensors for various substances, including biological and neuroscience uses, as well as advancements in quantum communication technologies. This nanomaterial breakthrough holds the promise of inspiring exciting innovations in the future.