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Categories: Anthropology: Early Humans, Biology: Microbiology

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Some HIV-1 carriers who have received an early antiretroviral treatment during several years are able to control the virus for a long term after treatment interruption. However, the mechanisms enabling this post-treatment control have not been fully elucidated. Scientists have now investigated and revealed how neutralizing antibodies, including those described as broadly neutralizing, contribute to virus control. A clinical trial involving the use of broadly neutralizing antibodies should begin in France before the end of 2023.

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Fungal infections are killing thousands of Americans each year, some with a morbidity rate of nearly 80%. To make matters worse, only a handful of antifungal treatments are available, and even those are becoming less effective as fungi become more resistant. However, researchers recently published findings indicating that a novel breakthrough treatment may have been discovered.

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Epstein-Barr virus (EBV) infection is known to convert resting B lymphocytes into immortal cells that continuously multiply, leading to posttransplant lymphoproliferative disorder (PTLD). Researchers have now uncovered the molecular mechanisms of this growth transformation, demonstrating the crucial role of the cancer-related gene IMPDH2 and nucleolar enlargement. Additionally, the research revealed strong evidence supporting the efficacy of mycophenolate mofetil, an approved immunosuppressant, in inhibiting PTLD, highlighting its therapeutic significance.

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Bacteria make up more than 10% of all living things but until recently we had little realization that, as in humans, soil bacteria have internal clocks that synchronize their activities with the 24-hour cycles of day and night on Earth. New research shows just how complex and sophisticated these bacterial circadian clocks are, clearing the way for an exciting new phase of study.

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Researchers have discovered a previously unknown mechanism by which bacteria share their genetic material through virus parasites. The insights could help scientists to better understand how bacteria rapidly adapt and evolve, and how they become more virulent and resistant to antibiotics.

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Hospital-acquired infections are often hard to treat because the corresponding pathogens become increasingly resistant against antibiotics. The bacterium Acinetobacter baumannii is particularly feared, and there is great pressure to devise novel therapeutic approaches to combat it. Bioinformaticians have now detected an unexpectedly wide diversity of certain cell appendages in A. baumannii that are associated with pathogenicity. This could lead to treatment strategies that are specifically tailored to a particular pathogen.

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In temperate climates, like North America and Europe, flu season starts in the fall, peaks in the winter and ends in the spring. While public health officials have generally assumed that influenza is also seasonal in tropical climates, new research has found little evidence of a repeatable pattern in influenza cases in Vietnam. The findings suggest that influenza is likely unpredictable throughout the tropics, posing substantial challenges for prevention and management of cases for the one-third of the global population living in tropical areas.

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Four years ago, a report that a common species of fungus might fuel pancreatic cancer offered a promising new view of the deadly disease. But in working to validate the finding, researchers have found no such association.

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A study on almost four thousand people of African descent has identified a gene that acts as natural defense against HIV by limiting its replication in certain white blood cells. This research paves the way for new treatment strategies and underscores the importance of studying diverse ancestral populations to better address their specific medical needs and global health disparities.

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A team of scientists has made an important breakthrough in the fight against RNA viruses that cause human diseases and pandemics.

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Antiviral therapies are notoriously difficult to develop, as viruses can quickly mutate to become resistant to drugs. But what if a new generation of antivirals ignores the fast-mutating proteins on the surface of viruses and instead disrupts their protective layers?

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The availability, speed and effectiveness of genomic sequencing increased dramatically during the pandemic, as scientists worldwide rushed to find ways to track and predict the virus's movement and evolution. It also was critical in the development of effective vaccines. Biologists argue that building on this momentum is critical in society's response to future pandemics, but it requires significant collaboration and investment now, before the next pathogen is threatening society.

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Researchers have discovered a new way to attack fungal infections. The key is to block fungi from being able to make fatty acids, the major component of fats. Resistance to anti-fungal drugs is increasing and this new approach will be particularly useful because it works in a new way and affects a broad range of fungal species.

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Scientists showed that fixed mutations within a viral population most likely stem from how easy it is to acquire that mutation (i.e., mutation accessibility) rather than just its benefit.

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Ancient pathogens that escape from melting permafrost have real potential to damage microbial communities and might potentially threaten human health, according to a new study.

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A new study of the strain of influenza A responsible for the 2009 H1N1 pandemic -- pdm09 -- shows that the virus has passed from humans to swine about 370 times since 2009, and subsequent circulation in swine has resulted in the evolution of pdm09 variants that then jumped from swine to humans.

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An international team of linguists and geneticists has achieved a significant breakthrough in our understanding of the origins of Indo-European, a family of languages spoken by nearly half of the world's population.

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Dozens of viruses -- at least -- can eavesdrop on host information. Not only did they demonstrate the strategy's abundance, but they also discovered tools that control it and send signals that tell bacteriophage viruses to flip from chill (lysogeny) into kill (lysis) mode. They showed that in polylysogeny, phages can coexist, their viral DNA or RNA hidden tucked inside the bacterium's own, replicating right along with the cells. But the infiltrating phages aren't exactly peaceful; it's more like mutually assured destruction. And the tenuous detente lasts only until something triggers one or more of the phages to switch into kill mode.

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The Neolithic burial site of Gurgy 'les Noisats' in France revealed two unprecedentedly large family trees which allowed a Franco-German team to explore the social organization of the 6,700-year-old community. Based on multiple lines of evidence, the team describes a close kin group which practiced monogamy and female exogamy, and experienced generally stable times.

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The results of a novel study has revealed exciting findings in the pursuit of an HIV cure.