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Categories: Chemistry: Biochemistry, Space: Astronomy

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Meet SQUID, a new computational tool. Compared with other genomic AI models, SQUID is more consistent, reduces background noise, and can yield better predictions regarding critical mutations. The new system aims to bring scientists closer to their findings' true medical implications.

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Researchers have discovered that by shining different wavelengths (colors) of light on a material called magnetite, they can change its state, e.g. making it more or less conducive to electricity. The discovery could lead to new ways of designing new materials for electronics such as memory storage, sensors, and other devices that rely on fast and efficient material responses.

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Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these proteins from cell membranes.

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Biomedical engineers have grown muscles in a lab to better understand and test treatments for a group of extremely rare muscle disorders called dysferlinopathy or limb girdle muscular dystrophies 2B (LGMD2B). The research revealed the biological mechanisms underlying the disease and showed that a combination of existing treatments could alleviate its symptoms.

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What actually happens to the human body in space? While scientists and researchers have heavily researched how various factors impact the human body here on Earth, the amount of information available about changes that occur in the body in space is not as well-known. Scientists have been studying for years how the body, specifically on the molecular side, changes in space. Recently, findings depict how the modern tools of molecular biology and precision medicine can help guide humanity into more challenging missions beyond where we've already been.

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Iron meteorites are remnants of the metallic cores of the earliest asteroids in our solar system. Iron meteorites contain refractory metals, such as iridium and platinum, that formed near the sun but were transported to the outer solar system. New research shows that for this to have happened, the protoplanetary disk of our solar system had to have been doughnut-shaped because the refractory metals could not have crossed the large gaps in a target-shaped disk of concentric rings. The paper suggests that the refractory metals moved outward as the protoplanetary disk rapidly expanded, and were trapped in the outer solar system by Jupiter.

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Argonne scientists have used isoporous membranes -- membranes with pores of equal size and shape -- and recirculation to create separations at the nanoscale that overcome previous limitations.

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Supermassive black holes pose unanswered questions for astronomers around the world, not least 'How do they grow so big?' Now, an international team of astronomers has discovered a powerful rotating, magnetic wind that they believe is helping a galaxy's central supermassive black hole to grow. The swirling wind, revealed with the help of the ALMA telescope in nearby galaxy ESO320-G030, suggests that similar processes are involved both in black hole growth and the birth of stars.

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Scientists have prototyped a new method for 'rationally engineering' enzymes to deliver improved performance. They have devised an algorithm, which takes into account an enzyme's evolutionary history, to flag where mutations could be introduced with a high likelihood of delivering functional improvements. Their work could have significant, wide-ranging impacts across a suite of industries, from food production to human health.

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A team of researchers has developed a gel electret capable of stably retaining a large electrostatic charge. The team then combined this gel with highly flexible electrodes to create a sensor capable of perceiving low-frequency vibrations (e.g., vibrations generated by human motion) and converting them into output voltage signals. This device may potentially be used as a wearable healthcare sensor.

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Jupiter's iconic Great Red Spot has persisted for at least 190 years and is likely a different spot from the one observed by the astronomer Giovanni Domenico Cassini in 1665, a new study reports. The Great Red Spot we see today likely formed because of an instability in the planet's intense atmospheric winds, producing a long, persistent atmospheric cell, the study also finds.

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An innovative synthesis strategy opened up the way to 2D/3D fused frameworks using inexpensive quinolines as feedstock, report scientists. By leveraging a light-sensitive borate intermediate, the scientists could transform quinoline derivatives into a great variety of 2D/3D fused frameworks in a straightforward and cost-effective manner. Their findings are expected to enable the synthesis of highly customizable drug candidates.

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Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks. The cells navigate through complex environments. A new approach now shows how they do this and how they interact with each other.

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Much of the methane released into the southern Baltic Sea from the Nord Stream gas pipeline has remained in the water. This is shown by measurements taken by researchers from the University of Gothenburg.

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A team has invented a technique to study electrochemical processes at the atomic level with unprecedented resolution. They have already used it to discover a surprising phenomena in a popular catalyst material and plan to apply their technology to studying a wide variety of electrochemical systems including batteries, fuel cells, and solar fuel generators. The insights could lead to more efficient and durable devices.

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Researchers have created a new class of materials called 'glassy gels' that are very hard and difficult to break despite containing more than 50% liquid. Coupled with the fact that glassy gels are simple to produce, the material holds promise for a variety of applications.

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More than 130 years after cyclodextrins were first discovered and reported, a team of scientists has created chemical mirror images of these complex carbohydrates in the laboratory. This discovery may revolutionize how medications are delivered to patients.

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Telo-seq -- a new tool -- is bringing telomere science into its modern era. Scientists can finally explore questions about the role of telomeres in aging and cancer that were not accessible with previous methods. The findings will inspire novel telomere-targeting therapeutics for aging-related diseases.

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In late 2019 the previously unremarkable galaxy SDSS1335+0728 suddenly started shining brighter than ever before. To understand why, astronomers have used data from several space and ground-based observatories, including the European Southern Observatory's Very Large Telescope (ESO's VLT), to track how the galaxy's brightness has varied. In a study out today, they conclude that they are witnessing changes never seen before in a galaxy -- likely the result of the sudden awakening of the massive black hole at its core.

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Researchers used theoretical calculations assessing electron orbital symmetry to synthesize new molecule designed to be both transparent and colorless while absorbing near-infrared light. This compound demonstrates the first systematic approach to producing such materials and have applications in advanced electronics. This compound also shows semiconducting properties.