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Categories: Chemistry: Biochemistry, Environmental: Water

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Chemical and heat treatment of sewage sludge can recover phosphorus in a process that could help address the problem of diminishing supplies of phosphorus ores.

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For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.

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Extracting natural gas from shale formations can provide an abundant, lower-carbon footprint fossil fuel, but also creates concerns over increased methane emissions. Researchers have now developed a new tool that can estimate the emission potential of shale wells after they are no longer active.

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A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.

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Oil is an important natural resource for many industries, but it can lead to serious environmental damage when accidentally spilled. While large oil spills are highly publicized, every year there are many smaller-scale spills into lakes, rivers and oceans. The longer that oil remains in freshwater, the more chemical changes it undergoes, creating products that can persist in the environment.

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Scientists have watched a molecule move across a graphite surface in unprecedented detail. It turns out this particular molecule moves like a Moon lander -- and the insights hold potential for future nanotechnologies.

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How do birds fly in a coordinated and seemingly effortless fashion? Part of the answer lies in precise, and previously unknown, aerodynamic interactions, reports a team of mathematicians. Its breakthrough broadens our understanding of wildlife, including fish, who move in schools, and could have applications in transportation and energy.

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Researchers have pioneered a breakthrough in ferroelectric material development. They've engineered a novel displacement-type ferroelectric material boasting remarkable dielectric properties. Their achievement includes the successful synthesis of rubidium niobate (RbNbO3), a compound previously deemed challenging to produce under pressures exceeding 40,000 atmospheres. Additionally, they characterized how polarization changes across a wide temperature range during phase transitions. This breakthrough can lead to new design guidelines for ferroelectric materials.

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'Bookworm' is a cute thing to call a voracious reader, but actual bookworms -- as well as microorganisms and time -- break down the flour pastes commonly used to keep old publications in one piece. Now, researchers have analyzed the proteins in wheat-based glues applied in historic bookbinding to provide insights on their adhesiveness and how they degrade. This information could help conservators restore and preserve treasured tomes for future generations.

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Hydrologists predict human-induced underground fluid fluxes to rise with climate change mitigation strategies like carbon sequestration.

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Just as water moves through a river, rivers themselves move across the landscape. They carve valleys and canyons, create floodplains and deltas, and transport sediment from the uplands to the ocean.

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Researchers discovered that light can cause evaporation of water from a surface without the need for heat. This 'photomolecular effect' could be important for understanding climate change and for improving some industrial processes.

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Robotics engineers have worked for decades and invested many millions of research dollars in attempts to create a robot that can walk or run as well as an animal. And yet, it remains the case that many animals are capable of feats that would be impossible for robots that exist today.

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A special nanostructure has been developed to filter a widespread class of harmful dyes from water. A crucial component is a material that is considered waste: used cellulose, for example in the form of cleaning cloths or paper cups. The cellulose is utilized to coat a fine nano-fabric to create an efficient filter for polluted water.

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A new model extends the theory of elastic phase separation towards nanoscopic structures. Such patterns are frequent in biological systems and also used in nano-engineering to create structural color. With their new insights, the scientists can predict the length scale of nanoscopic patterns and thus control them during production.

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Estuaries -- where freshwater rivers meet the salty sea -- are great locations for birdwatching and kayaking. In these areas, waters containing different salt concentrations mix and may be sources of sustainable, 'blue' osmotic energy. Researchers report creating a semipermeable membrane that harvests osmotic energy from salt gradients and converts it to electricity. The new design had an output power density more than two times higher than commercial membranes in lab demonstrations.

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Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.

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Scientists demonstrated the first-ever remote observations of the fine-scale structure at the base of clouds. The results show that the air-cloud interface is a transition zone where aerosol particles suspended in Earth's atmosphere give rise to the droplets that ultimately form clouds. The research will enable scientists to gain insight into how changes in atmospheric aerosol levels could affect clouds and climate.

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A mystery that has puzzled the scientific community for over 50 years has finally been solved. A team has discovered that a certain type of chemical reaction can explain why organic matter found in rivers and lakes is so resistant to degradation.

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In a significant development in the field of superconductivity, researchers have successfully achieved robust superconductivity in high magnetic fields using a newly created one-dimensional (1D) system. This breakthrough offers a promising pathway to achieving superconductivity in the quantum Hall regime, a longstanding challenge in condensed matter physics.