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Categories: Chemistry: Inorganic Chemistry, Chemistry: Organic Chemistry
Published Getting dynamic information from static snapshots
(via sciencedaily.com) Original source Researchers have created TopicVelo, a powerful new method of using the static snapshots from scRNA-seq to study how cells and genes change over time. This will help researchers better study how embryos develop, cells differentiate, cancers form, and the immune system reacts.
Published More efficient molecular motor widens potential applications
(via sciencedaily.com) Original source Light-driven molecular motors were first developed nearly 25 years ago. However, making these motors do actual work proved to be a challenge. In a new paper, scientists describe improvements that bring real-life applications closer.
Published A shortcut for drug discovery
(via sciencedaily.com) Original source For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.
Published Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments
(via sciencedaily.com) Original source A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.
Published The longer spilled oil lingers in freshwater, the more persistent compounds it produces
(via sciencedaily.com) Original source Oil is an important natural resource for many industries, but it can lead to serious environmental damage when accidentally spilled. While large oil spills are highly publicized, every year there are many smaller-scale spills into lakes, rivers and oceans. The longer that oil remains in freshwater, the more chemical changes it undergoes, creating products that can persist in the environment.
Published Key to efficient and stable organic solar cells
(via sciencedaily.com) Original source A team of researchers has made a significant breakthrough in the field of organic photovoltaics.
Published Diamond dust shines bright in Magnetic Resonance Imaging
(via sciencedaily.com) Original source An unexpected discovery surprised a scientist: nanometer-sized diamond particles, which were intended for a completely different purpose, shone brightly in a magnetic resonance imaging experiment -- much brighter than the actual contrast agent, the heavy metal gadolinium. Could diamond dust -- in addition to its use in drug delivery to treat tumor cells -- one day become a novel contrast agent used for MRI?
Published 'Like a nanoscopic Moon lander': Scientists unlock secret of how pyramidal molecules move across surfaces
(via sciencedaily.com) Original source Scientists have watched a molecule move across a graphite surface in unprecedented detail. It turns out this particular molecule moves like a Moon lander -- and the insights hold potential for future nanotechnologies.
Published Freeze casting: A guide to creating hierarchically structured materials
(via sciencedaily.com) Original source Freeze casting is an elegant, cost-effective manufacturing technique to produce highly porous materials with custom-designed hierarchical architectures, well-defined pore orientation, and multifunctional surface structures. Freeze-cast materials are suitable for many applications, from biomedicine to environmental engineering and energy technologies.
Published The secret to saving old books could be gluten-free glues
(via sciencedaily.com) Original source 'Bookworm' is a cute thing to call a voracious reader, but actual bookworms -- as well as microorganisms and time -- break down the flour pastes commonly used to keep old publications in one piece. Now, researchers have analyzed the proteins in wheat-based glues applied in historic bookbinding to provide insights on their adhesiveness and how they degrade. This information could help conservators restore and preserve treasured tomes for future generations.
Published Biophysics: Testing how well biomarkers work
(via sciencedaily.com) Original source Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.
Published A chemical mystery solved -- the reaction explaining large carbon sinks
(via sciencedaily.com) Original source A mystery that has puzzled the scientific community for over 50 years has finally been solved. A team has discovered that a certain type of chemical reaction can explain why organic matter found in rivers and lakes is so resistant to degradation.
Published Making diamonds at ambient pressure
(via sciencedaily.com) Original source Researchers have grown diamonds under conditions of 1 atmosphere pressure and at 1025 degrees Celsius using a liquid metal alloy composed of gallium, iron, nickel, and silicon, thus breaking the existing paradigm. The discovery of this new growth method opens many possibilities for further basic science studies and for scaling up the growth of diamonds in new ways.
Published Lead-vacancy centers in diamond as building blocks for large-scale quantum networks
(via sciencedaily.com) Original source A lead-vacancy (PbV) center in diamond has been developed as a quantum emitter for large-scale quantum networks by researchers. This innovative color center exhibits a sharp zero-phonon-line and emits photons with specific frequencies. The PbV color center stands out among other diamond color centers due to its ability to maintain optical properties at relatively high temperatures of 16 K. This makes it well-suited for transferring quantum information in large-scale quantum networks.
Published Critical minerals recovery from electronic waste
(via sciencedaily.com) Original source A nontoxic separation process recovers critical minerals from electronic scrap waste.
Published Researchers create artificial cells that act like living cells
(via sciencedaily.com) Original source Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.
Published Magnetic with a pinch of hydrogen
(via sciencedaily.com) Original source Magnetic two-dimensional materials consisting of one or a few atomic layers have only recently become known and promise interesting applications, for example for the electronics of the future. So far, however, it has not been possible to control the magnetic states of these materials well enough. A research team is now presenting an innovative idea that could overcome this shortcoming -- by allowing the 2D layer to react with hydrogen.
Published More economical and sustainable rechargeable batteries
(via sciencedaily.com) Original source Lithium salts make batteries powerful but expensive. An ultralow-concentration electrolyte based on the lithium salt LiDFOB may be a more economical and more sustainable alternative. Cells using these electrolytes and conventional electrodes have been demonstrated to have high performance. In addition, the electrolyte could facilitate both production and recycling of the batteries.
Published New copper-catalyzed C-H activation strategy
(via sciencedaily.com) Original source Inspired by what human liver enzymes can do, chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions are expected to be widely used in drug discovery and optimization, as well as in other chemistry-based industries.
Published Development of organic semiconductors featuring ultrafast electrons
(via sciencedaily.com) Original source Collaboration has led to the successful observation of these ultrafast electrons within conducting two-dimensional polymers.