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Categories: Chemistry: Organic Chemistry, Space: Astronomy
Published Research on RNA editing illuminates possible lifesaving treatments for genetic diseases



The research explores how CRISPR can be used to edit RNA.
Published When does a conductor not conduct?



A new study uncovers a switchable, atomically-thin metal-organic material that could be used in future low-energy electronic technologies. The study shows that electron interactions in this material create an unusual electrically-insulating phase in which electrons are 'frozen'. By reducing the population of electrons, the authors are able to unfreeze the remaining electrons, allowing for controlled transitions between insulating and electrically-conductive phases: the key to the on-off binary operations of classical computing.
Published Probing the effects of interplanetary space on asteroid Ryugu



Samples reveal evidence of changes experienced by the surface of asteroid Ryugu, some probably due to micrometeoroid bombardment.
Published Getting dynamic information from static snapshots



Researchers have created TopicVelo, a powerful new method of using the static snapshots from scRNA-seq to study how cells and genes change over time. This will help researchers better study how embryos develop, cells differentiate, cancers form, and the immune system reacts.
Published A shortcut for drug discovery



For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.
Published Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments



A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.
Published The longer spilled oil lingers in freshwater, the more persistent compounds it produces



Oil is an important natural resource for many industries, but it can lead to serious environmental damage when accidentally spilled. While large oil spills are highly publicized, every year there are many smaller-scale spills into lakes, rivers and oceans. The longer that oil remains in freshwater, the more chemical changes it undergoes, creating products that can persist in the environment.
Published The secret to saving old books could be gluten-free glues



'Bookworm' is a cute thing to call a voracious reader, but actual bookworms -- as well as microorganisms and time -- break down the flour pastes commonly used to keep old publications in one piece. Now, researchers have analyzed the proteins in wheat-based glues applied in historic bookbinding to provide insights on their adhesiveness and how they degrade. This information could help conservators restore and preserve treasured tomes for future generations.
Published Biophysics: Testing how well biomarkers work



Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.
Published A chemical mystery solved -- the reaction explaining large carbon sinks



A mystery that has puzzled the scientific community for over 50 years has finally been solved. A team has discovered that a certain type of chemical reaction can explain why organic matter found in rivers and lakes is so resistant to degradation.
Published Eruption of mega-magnetic star lights up nearby galaxy



While ESA's satellite INTEGRAL was observing the sky, it spotted a burst of gamma-rays -- high-energy photons -- coming from the nearby galaxy M82. Only a few hours later, ESA's XMM-Newton X-ray space telescope searched for an afterglow from the explosion but found none. An international team realized that the burst must have been an extra-galactic flare from a magnetar, a young neutron star with an exceptionally strong magnetic field.
Published Researchers create artificial cells that act like living cells



Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.
Published Toward unification of turbulence framework -- weak-to-strong transition discovered in turbulence



Astrophysicists have made a significant step toward solving the last puzzle in magnetohydrodynamic turbulence theory by observing the weak to strong transition in the space plasma turbulence surrounding Earth with newly developed multi-spacecraft analysis methods.
Published To find life in the universe, look to deadly Venus



Despite surface temperatures hot enough to melt lead, lava-spewing volcanoes, and puffy clouds of sulfuric acid, uninhabitable Venus offers vital lessons about the potential for life on other planets, a new paper argues.
Published Giant galactic explosion exposes galaxy pollution in action



Astronomers have produced the first high-resolution map of a massive explosion in a nearby galaxy, providing important clues on how the space between galaxies is polluted with chemical elements.
Published AI and physics combine to reveal the 3D structure of a flare erupting around a black hole



Based on radio telescope data and models of black hole physics, a team has used neural networks to reconstruct a 3D image that shows how explosive flare-ups in the disk of gas around our supermassive black hole might look.
Published New copper-catalyzed C-H activation strategy



Inspired by what human liver enzymes can do, chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions are expected to be widely used in drug discovery and optimization, as well as in other chemistry-based industries.
Published Light show in living cells



Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.
Published Astronomers uncover methane emission on a cold brown dwarf



Astronomers have discovered methane emission on a brown dwarf, an unexpected finding for such a cold and isolated world. The findings suggest that this brown dwarf might generate aurorae similar to those seen on our own planet as well as on Jupiter and Saturn.
Published From defects to order: Spontaneously emerging crystal arrangements in perovskite halides



A new hybrid layered perovskite featuring elusive spontaneous defect ordering has been found, report scientists. By introducing specific concentrations of thiocyanate ions into FAPbI3 (FA = formamidinium), they observed that ordered columnar defects appeared in the stacked crystalline layers, taking up one-third of the lattice space. These findings could pave the way to an innovative strategy for adjusting the properties of hybrid perovskites, leading to practical advances in optoelectronics and energy generation.