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Categories: Chemistry: Organic Chemistry, Space: Exploration

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For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.

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A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.

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Oil is an important natural resource for many industries, but it can lead to serious environmental damage when accidentally spilled. While large oil spills are highly publicized, every year there are many smaller-scale spills into lakes, rivers and oceans. The longer that oil remains in freshwater, the more chemical changes it undergoes, creating products that can persist in the environment.

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'Bookworm' is a cute thing to call a voracious reader, but actual bookworms -- as well as microorganisms and time -- break down the flour pastes commonly used to keep old publications in one piece. Now, researchers have analyzed the proteins in wheat-based glues applied in historic bookbinding to provide insights on their adhesiveness and how they degrade. This information could help conservators restore and preserve treasured tomes for future generations.

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Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.

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A mystery that has puzzled the scientific community for over 50 years has finally been solved. A team has discovered that a certain type of chemical reaction can explain why organic matter found in rivers and lakes is so resistant to degradation.

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While ESA's satellite INTEGRAL was observing the sky, it spotted a burst of gamma-rays -- high-energy photons -- coming from the nearby galaxy M82. Only a few hours later, ESA's XMM-Newton X-ray space telescope searched for an afterglow from the explosion but found none. An international team realized that the burst must have been an extra-galactic flare from a magnetar, a young neutron star with an exceptionally strong magnetic field.

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Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

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Astrophysicists have made a significant step toward solving the last puzzle in magnetohydrodynamic turbulence theory by observing the weak to strong transition in the space plasma turbulence surrounding Earth with newly developed multi-spacecraft analysis methods.

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Despite surface temperatures hot enough to melt lead, lava-spewing volcanoes, and puffy clouds of sulfuric acid, uninhabitable Venus offers vital lessons about the potential for life on other planets, a new paper argues.

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Astronomers have produced the first high-resolution map of a massive explosion in a nearby galaxy, providing important clues on how the space between galaxies is polluted with chemical elements.

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Simulated effects of microgravity significantly affect rhythmicity and sleep in humans, a new study finds. Such disturbances could negatively affect the physiology and performance of astronauts in space.

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Based on radio telescope data and models of black hole physics, a team has used neural networks to reconstruct a 3D image that shows how explosive flare-ups in the disk of gas around our supermassive black hole might look.

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Inspired by what human liver enzymes can do, chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions are expected to be widely used in drug discovery and optimization, as well as in other chemistry-based industries.

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Researchers have found that modern weather models can accurately predict the energy that Earth emits and reflects into space, which directly affects the movements of low Earth-orbiting (LEO) satellites. By leveraging these models, the researchers gained insights into how LEO satellites respond to weather events below, such as tropical cyclones with tall and reflective clouds.

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Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.

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Astronomers have discovered methane emission on a brown dwarf, an unexpected finding for such a cold and isolated world. The findings suggest that this brown dwarf might generate aurorae similar to those seen on our own planet as well as on Jupiter and Saturn.

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A new hybrid layered perovskite featuring elusive spontaneous defect ordering has been found, report scientists. By introducing specific concentrations of thiocyanate ions into FAPbI3 (FA = formamidinium), they observed that ordered columnar defects appeared in the stacked crystalline layers, taking up one-third of the lattice space. These findings could pave the way to an innovative strategy for adjusting the properties of hybrid perovskites, leading to practical advances in optoelectronics and energy generation.

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Scientists have developed a new method using knot theory to find the optimal routes for future space missions without the need to waste fuel.

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A nearby supernova in 2023 offered astrophysicists an excellent opportunity to test ideas about how these types of explosions boost particles, called cosmic rays, to near light-speed. But surprisingly, NASA's Fermi Gamma-ray Space Telescope detected none of the high-energy gamma-ray light those particles should produce.