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Categories: Anthropology: General, Chemistry: Organic Chemistry
Published Scientists solve chemical mystery at the interface of biology and technology
(via sciencedaily.com) Original source Organic electrochemical transistors (OECTs) allow current to flow in devices like implantable biosensors. But scientists long knew about a quirk of OECTs that no one could explain: When an OECT is switched on, there is a lag before current reaches the desired operational level. When switched off, there is no lag. Current drops immediately. Researchers report that they have discovered the reason for this activation lag, and in the process are paving the way to custom-tailored OECTs for a growing list of applications in biosensing, brain-inspired computation and beyond.
Published How evolving landscapes impacted First Peoples' early migration patterns into Australia
(via sciencedaily.com) Original source Scientists have applied a dynamic model of the landscape to patterns of human migration into Sahul, the combined continent of Australia, Tasmania and New Guinea.
Published Research on RNA editing illuminates possible lifesaving treatments for genetic diseases
(via sciencedaily.com) Original source The research explores how CRISPR can be used to edit RNA.
Published More plants on the menu of ancient hunter-gatherers
(via sciencedaily.com) Original source It has long been thought that meat played an important role in the diet of hunter-gatherers before the Neolithic transition. However, due to the scarcity of well-preserved human remains from Paleolithic sites, little information exists about the dietary habits of pre-agricultural human groups. A new study challenges this notion by presenting compelling isotopic evidence of a strong preference for plants among 15,000-year-old hunter-gatherers from Morocco. This is the first time a significant amount of plant consumption has been measured for a pre-agricultural population, shedding new light on the dietary practices of ancient human societies.
Published When does a conductor not conduct?
(via sciencedaily.com) Original source A new study uncovers a switchable, atomically-thin metal-organic material that could be used in future low-energy electronic technologies. The study shows that electron interactions in this material create an unusual electrically-insulating phase in which electrons are 'frozen'. By reducing the population of electrons, the authors are able to unfreeze the remaining electrons, allowing for controlled transitions between insulating and electrically-conductive phases: the key to the on-off binary operations of classical computing.
Published Getting dynamic information from static snapshots
(via sciencedaily.com) Original source Researchers have created TopicVelo, a powerful new method of using the static snapshots from scRNA-seq to study how cells and genes change over time. This will help researchers better study how embryos develop, cells differentiate, cancers form, and the immune system reacts.
Published Ancient Maya blessed their ballcourts
(via sciencedaily.com) Original source Using environmental DNA analysis, an international team of researchers identified a collection of plants used in ceremonial rituals in the ancient Maya city of Yaxnohcah in Mexico. The plants, known for their religious associations and medicinal properties, were discovered beneath a plaza floor where a ballcourt was built.
Published A shortcut for drug discovery
(via sciencedaily.com) Original source For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.
Published Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments
(via sciencedaily.com) Original source A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.
Published The longer spilled oil lingers in freshwater, the more persistent compounds it produces
(via sciencedaily.com) Original source Oil is an important natural resource for many industries, but it can lead to serious environmental damage when accidentally spilled. While large oil spills are highly publicized, every year there are many smaller-scale spills into lakes, rivers and oceans. The longer that oil remains in freshwater, the more chemical changes it undergoes, creating products that can persist in the environment.
Published The secret to saving old books could be gluten-free glues
(via sciencedaily.com) Original source 'Bookworm' is a cute thing to call a voracious reader, but actual bookworms -- as well as microorganisms and time -- break down the flour pastes commonly used to keep old publications in one piece. Now, researchers have analyzed the proteins in wheat-based glues applied in historic bookbinding to provide insights on their adhesiveness and how they degrade. This information could help conservators restore and preserve treasured tomes for future generations.
Published Biophysics: Testing how well biomarkers work
(via sciencedaily.com) Original source Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.
Published Decoding Avar society
(via sciencedaily.com) Original source A multidisciplinary research team has combined ancient DNA data with a clear archaeological, anthropological and historical context to reconstruct the social dynamics of Avar-period steppe descent populations that settled in Europe's Carpathian Basin in the 6th century.
Published A chemical mystery solved -- the reaction explaining large carbon sinks
(via sciencedaily.com) Original source A mystery that has puzzled the scientific community for over 50 years has finally been solved. A team has discovered that a certain type of chemical reaction can explain why organic matter found in rivers and lakes is so resistant to degradation.
Published Bioluminescence first evolved in animals at least 540 million years ago
(via sciencedaily.com) Original source Bioluminescence first evolved in animals at least 540 million years ago in a group of marine invertebrates called octocorals, according to the results of a new study. The study focuses on an ancient group of marine invertebrates that includes soft corals, pushes back the previous oldest dated example of trait by nearly 300 million years.
Published Researchers create artificial cells that act like living cells
(via sciencedaily.com) Original source Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.
Published New copper-catalyzed C-H activation strategy
(via sciencedaily.com) Original source Inspired by what human liver enzymes can do, chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions are expected to be widely used in drug discovery and optimization, as well as in other chemistry-based industries.
Published 'Forgotten city:' the identification of Dura-Europos' neglected sister site in Syria
(via sciencedaily.com) Original source The Dura-Europos site in modern-day Syria is famous for its exceptional state of preservation. Like Pompeii, this ancient city has yielded many great discoveries, and serves as a window into the world of the ancient Hellenistic, Parthian, and Roman periods. Yet despite the prominence of Dura-Europos in Near Eastern scholarship, there is another city, only some miles down the Euphrates river, that presents a long-neglected opportunity for study.
Published Light show in living cells
(via sciencedaily.com) Original source Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.
Published First evidence of human occupation in lava tube cave in Saudi Arabia
(via sciencedaily.com) Original source New research has highlighted an area in Arabia that once acted as a key point for cultural exchanges and trades amongst ancient people -- and it all took place in vast caves and lava tubes that have remained largely untapped reservoirs of archaeological abundance in Arabia. Through meticulous excavation and analysis, the international team uncovered a wealth of evidence at Umm Jirsan, spanning from the Neolithic to the Chalcolithic/Bronze Age periods (~10,000-3,500 years ago).