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Categories: Anthropology: General, Chemistry: Organic Chemistry

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A scientist combines attention neural networks with graph neural networks to better understand and design proteins. The approach couples the strengths of geometric deep learning with those of language models to predict existing protein properties and envision new proteins that nature has not yet devised. The model turns numbers, descriptions, tasks, and other elements into symbols for neural networks to use.

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Iron--sulfur (Fe--S) proteins, essential to all life forms, are difficult to synthesise due to the complicated molecular machinery involved and sensitivity of Fe--S clusters to oxygen. In a new study, a team of researchers devised an innovative protocol for synthesising mature Fe--S proteins, by bringing together a recombinant sulfur assimilation (SUF) system and an oxygen-scavenging system, thereby, paving the way for new technologies and a better understanding of the evolution of life.

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Scientists use cutting edge scanning technology to reconstruct 'fossil monster' that lived half a billion years ago. The creature's soft anatomy was well-preserved, allowing it to be imaged almost completely: It fills a gap in our understanding of the evolution of arthropods such as insects and crustaceans.

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An organometallic capsule that can reversibly assemble and disassemble in response to chemical stimuli was recently developed by chemists. Comprising ferrocene-based bent amphiphiles, this new capsule can act as a host for various types of guest molecules, such as electron acceptors and dyes. Thanks to the controllable release of its cargo, the capsule would find applications in catalysis, medicine, and biotechnology.

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Methylcyclohexane is very promising as a hydrogen carrier that can safely and efficiently transport and store hydrogen. However, the dehydrogenation process using catalysts has issues due to its durability and large energy loss. Recently, researchers have succeeded in using solid oxide fuel cells to generate electricity directly from methylcyclohexane and recover toluene for reuse. This research is expected to not only reduce energy requirements but also explore new chemical synthesis by fuel cells.

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Researchers have looked beyond biochemistry to publish groundbreaking work on the physics of fat droplets found inside many types of cells, revealing them to be a potential threat to a cell's nucleus.They have discovered fat-filled lipid droplets' surprising capability to indent and puncture the nucleus, the organelle which contains and regulates a cell's DNA. The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.

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Using a trapped-ion quantum computer, the research team witnessed the interference pattern of a single atom caused by a 'conical intersection'. Conical intersections are known throughout chemistry and are vital to rapid photo-chemical processes such as light harvesting in human vision or photosynthesis.

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A new article describes the 266 fossil species as one of the richest and most diverse groups of three-million-year-old fauna ever found in New Zealand. At least ten previously unknown species will be described and named in future research. Fossils of the world's oldest known flax snails, an extinct sawshark spine, and great white shark teeth have all been found in a mound of sand excavated from beneath Mangere Wastewater Treatment Plant in 2020.

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Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy.

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Mathematical modeling can show how to safely blend hydrogen with natural gas for transport in existing pipeline systems. A secure and reliable transition to hydrogen is one of the proposed solutions for the shift to a net-zero-carbon economy.

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A team of chemists have developed a novel concept in which a mixture of molecules that behave like mirror images is converted to a single form. To this end, they use light as external energy source. The conversion is relevant e.g. for the preparation of drugs.

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In the form of DNA, nature shows how data can be stored in a space-saving and long-term manner. Bioinformatics specialists are developing DNA chips for computer technology. Researchers show how a combination of molecular biology, nanotechnology, novel polymers, electronics and automation, coupled with systematic development, could make DNA data storage useful for everyday use possible in a few years.

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Researchers have dated drawings of Gua Sireh Cave in Sarawak, uncovering a sad story of conflict in the process.

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Immunotherapies for cancer aim to induce the immune system to combat cancer cells more effectively. A research team has now described a new, modular strategy for T-cell-based immunotherapy that manages to work without complex genetic modifications. Modulation of cell-cell communications through an ingenious regulatory circuit using various small, specially folded DNA molecules (aptamers) causes cancer cells to directly activate their mortal enemies, T cells.

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The near extinction of the North American bison in the late 1800s caused a devastating, lasting economic shock to Indigenous peoples whose lives depended on the animals, an economic study finds.

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Researchers have finally solved the long-standing puzzle of why graphene is so much more permeable to protons than expected by theory.

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A research team enhanced hydrogen evolution catalyst through stepwise deposition.

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Researchers have analyzed the genomes of skeletons from an extended family from a Bronze Age necropolis in the Russian steppe. The 3,800-year-old 'Nepluyevsky' burial mound was excavated several years ago and is located on the geographical border between Europe and Asia. Using statistical genomics, the family and marriage relationships of this society have now been deciphered.

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Which structures do complex proteins adopt in solution? Biophysicists answer this question using the example of ubiquitin dimers as well as a new combination of high-resolution NMR spectroscopy and sophisticated computer simulations.

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The world needs greener ways to make chemicals. In a new study, researchers demonstrate one potential path toward this goal by adapting hydrogen fuel cell technologies.