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Categories: Chemistry: Organic Chemistry, Paleontology: Early Mammals and Birds

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Norcembranolide diterpenes, isolated from the soft corals of the genus Sinularia, are important compounds for the development of new drugs, owing to their diverse biological activities. However, total synthesis methods for these compounds are scarce. Now, a team of researchers has achieved the total synthesis of scabrolide F, a norcembranolide diterpene. They also revealed its non-toxic antifouling properties. This novel method can lead to the development of new drugs and antifouling agents.

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Researchers have harnessed a bacterial immune defense system, known as CRISPR, to efficiently and precisely control the process of RNA splicing. The technology opens the door to new applications, including systematically interrogating the functions of parts of genes and correcting splicing deficiencies that underlie numerous diseases and disorders.

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Researchers have created a deep learning pipeline for designing soluble analogues of key protein structures used in pharmaceutical development, sidestepping the prohibitive cost of extracting these proteins from cell membranes.

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More than 130 years after cyclodextrins were first discovered and reported, a team of scientists has created chemical mirror images of these complex carbohydrates in the laboratory. This discovery may revolutionize how medications are delivered to patients.

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Researchers have developed innovative, eco-friendly quantum materials that can drive the transformation of methanol into ethylene glycol. This discovery opens up new possibilities for using eco-friendly materials in photocatalysis, paving the way for sustainable chemical production.

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Researchers used theoretical calculations assessing electron orbital symmetry to synthesize new molecule designed to be both transparent and colorless while absorbing near-infrared light. This compound demonstrates the first systematic approach to producing such materials and have applications in advanced electronics. This compound also shows semiconducting properties.

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A gold-coated milling vessel for ball mills proved to be a real marvel: without any solvents or environmentally harmful chemicals, the team was able to use it to convert alcohols into aldehydes. The catalytic reaction takes place at the gold surface and is mechanically driven. The vessel can be reused multiple times. 'This opens up new prospects for the use of gold in catalysis and shows how traditional materials can contribute to solving modern environmental problems in an innovative way,' says Borchardt.

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An international research team has succeeded in developing a new type of material in the rather young research field of covalent organic frameworks. The new two-dimensional polymer is characterized by the fact that its properties can be controlled in a targeted and reversible manner. This has brought the researchers a step closer to the goal of realizing switchable quantum states.

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A ubiquitous compound, called ester can be broken down to produce desirable alcohols and other chemicals for use across industries including pharmaceuticals and cosmetics, but the process can be costly, both financially and in terms of the environment. Researchers developed a novel photocatalyst 'N-BAP.' When irradiated with blue light, the photocatalyst reduces esters in the presence of oxalate, a negatively charged molecule found widely in nature, resulting in the desired alcohols.

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Researchers have succeeded in developing a DNA-based molecular controller. Crucially, this controller enables the autonomous assembly and disassembly of molecular robots, as opposed to manually directing it.

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Scientists are rethinking the evolution of vocal learning in birds. New Zealand's smallest bird, the rifleman or titipounamu, may have a rudimentary version of the talent possessed by parrots, hummingbirds and songbirds.

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With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.

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In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called 'symmetry breaking.'

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A team aims to improve options for renewable energy storage through work on an emerging technology -- liquids for hydrogen storage.

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The need to transition away from fossil fuels to more sustainable energy production is critical. That's why a team of researchers is looking at a potential power source that not only produces no carbon emissions but removes carbon as it works: algae.

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Scientists used CRISPR/Cas9 to increase gene expression in rice by changing its upstream regulatory DNA. While other studies have used the technology to knock out or decrease the expression of genes, this study, is an unbiased gene-editing approach to increase gene expression and downstream photosynthetic activity. The approach is more difficult than transgenic breeding, but could potentially preempt regulatory issues by changing DNA already within the plant, allowing the plants to get in the hands of farmers sooner.

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Ancient apes in Germany co-existed by partitioning resources in their environment, according to a new study.

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What species live in this coral reef, and are they healthy? Chemical clues emitted by marine organisms might hold that information. But in underwater environments, invisible compounds create a complex 'soup' that is hard for scientists to decipher. Now, researchers have demonstrated a way to extract and identify these indicator compounds in seawater. They found metabolites previously undetected on reefs, including three that may represent different reef organisms.

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Engineers have created a patent-pending method that creates layered perovskite nanowires with exceptionally well-defined and flexible cavities that exhibit a wide range of unusual optical properties beyond conventional perovskites.

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A team of researchers has developed a new method for target DNA sequence amplification, testing and analysis.