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Categories: Chemistry: Organic Chemistry, Offbeat: Paleontology and Archeology

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Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal and chemical stability as well as ability to inhibit specific enzymes or target proteins through three-dimensional binding. They also hold promise for swift diagnoses of colon cancer and other challenging diseases by targeting elusive biomarkers. Despite their utility, these aptamers are susceptible to easy degradation by multiple enzymes, presenting a significant challenge.

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A research team has achieved a significant breakthrough in the field of organic semiconductors. Their successful synthesis and characterization of a novel molecule called 'BNBN anthracene' has opened up new possibilities for the development of advanced electronic devices.

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Researchers have discovered that molecules experience non-reciprocal interactions without external forces. Fundamental forces such as gravity and electromagnetism are reciprocal, where two objects are attracted to each other or are repelled by each other. In our everyday experience, however, interactions don t seem to follow this reciprocal law.

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Researchers have developed a solid electrolyte for transporting hydride ions at room temperature. This breakthrough means that the full advantages of hydrogen-based solid-state batteries and fuel cells can be had without the need for constant hydration. This will reduce their complexity and cost, which is essential for advancing towards a practical hydrogen-based energy economy.

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Lights could soon use the full color suite of perfectly efficient organic light-emitting diodes, or OLEDs, that last tens of thousands of hours. The new phosphorescent OLEDs, commonly referred to as PHOLEDs, can maintain 90% of the blue light intensity for 10-14 times longer than other designs that emit similar deep blue colors. That kind of lifespan could finally make blue PHOLEDs hardy enough to be commercially viable in lights that meet the Department of Energy's 50,000-hour lifetime target. Without a stable blue PHOLED, OLED lights need to use less-efficient technology to create white light.

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Scientists have developed a method to extract the spectral density for molecules in solvent using simple resonance Raman experiments -- a method that captures the full complexity of chemical environments.

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A research team has unveiled a remarkable breakthrough in the form of a two-dimensional (2D) Metal Organic Framework (MOF) that showcases unprecedented origami-like movement at the molecular level. This pioneering study represents a significant leap forward in the field of dynamic materials, while also hinting at futuristic applications in metamaterials and quantum computing.

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A collaborative team of experimental and computational physical chemists has made an important discovery in the field of electrochemistry, shedding light on the movement of water molecules near metal electrodes. This research holds profound implications for the advancement of next-generation batteries utilizing aqueous electrolytes.

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Materials scientists developed a fast, low-cost, scalable method to make covalent organic frameworks (COFs), a class of crystalline polymers whose tunable molecular structure, large surface area and porosity could be useful in energy applications, semiconductor devices, sensors, filtration systems and drug delivery.

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Researchers developed a way to quickly calculate the transition state structure of a chemical reaction, using machine-learning models.

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Widespread caries and toothache -- but also some dental work and filing of front teeth. Viking Age teeth from Varnhem bear witness to surprisingly advanced dentistry.

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The high-altitude hero of the Himalayas, yak are among the few large animals that can survive the extremely cold, harsh and oxygen-poor conditions of the Tibetan Plateau. In the mountainous regions of Asia, yak and yak-cattle hybrids serve as vital sources of meat, milk, transportation and fuel. However, little is known about their history: when or where yak were domesticated. In a new study, researchers report archaeologically and genetically confirmed evidence for domestic yak, dating back 2,500 years, by far the oldest record.  

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Protein-splitting enzymes play an important role in many physiological processes. Such proteases are generally present in an inactive state, only becoming activated under certain conditions. Some are linked to diseases like infections or cancer, making it important to have methods that can selectively detect active proteases. Scientists have introduced a new class of protease-activity sensors: gold nanoparticles equipped with peptide DNA.

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Researchers have described a Japanese mosasaur the size of a great white shark that terrorized Pacific seas 72 million years ago. The mosasaur was named for the place where it was found, Wakayama Prefecture. Researchers call it the Wakayama Soryu, which means blue dragon.

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In mice and human cell cultures, researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer's disease.

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Antibodies hold promise as therapeutic agents. However, their tendency to aggregate poses significant challenges to drug development. In a groundbreaking study, researchers now provide novel insights into the structure formed due to 3D domain swapping of the antibody light chain, the part of the antibody contributing to antigen binding. Their findings are expected to lead to improvements in antibody quality and the development of novel drugs.

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After more than a decade of developing fluorescent probes, a research team has now released the culmination of their years of work: A comprehensive collection of rhodamine-based dyes, the novel chemistry they developed to synthesize them and insights that provide a roadmap for designing future probes.

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Researchers re-examined a plant fossil found decades ago in Colombia and realized that it wasn't a plant at all: it's a fossilized baby turtle. It's a rare find, because juvenile turtles' shells are soft and often don't fossilize well.

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Baboons were raised in captivity before being mummified in Ancient Egyptian sites, according to a new study.

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Chemists have now come up with a way to make molecules known as acenes more stable, allowing them to synthesize acenes of varying lengths. Using their new approach, they were able to build molecules that emit red, orange, yellow, green, or blue light, which could make acenes easier to deploy in a variety of applications.