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Categories: Chemistry: Biochemistry, Chemistry: Organic Chemistry

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RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste. Researchers report a new, enzyme-based RNA synthesis method that can produce strands of RNA with both natural and modified nucleotides without the environmental hazards.

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Scientists propose a new way of implementing a neural network with an optical system which could make machine learning more sustainable in the future. In a new paper, the researchers have demonstrated a method much simpler than previous approaches.

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Scientists have created a computer program that 'paints' the structure of molecules in the style of famous Dutch artist, Piet Mondrian. Researchers are opening eyes and minds to the beauty of molecular structure, as well as posing new questions about the form and function of the molecules themselves.

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A method to screen a wide variety of drug candidates without laborious purification steps could advance the fight against drug-resistant bacteria.

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In a new study, researchers used low-intensity ultrasound technology to noninvasively alter a brain region associated with activities such as daydreaming, recalling memories and envisioning the future.

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Neuroscientists have used a nanosized sensor to record spinal cord neurons in free-moving mice, a feat that could lead to the development of better treatments for spinal cord disease and injury.

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The flow of water within a muscle fiber may dictate how quickly muscle can contract, according to a new study.

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Researchers have made significant inroads in understanding how nanoplastics and per- and polyfluoroalkyl substances (PFAS) -- commonly known as forever chemicals -- disrupt biomolecular structure and function. The work shows that the compounds can alter proteins found in human breast milk and infant formulas -- potentially causing developmental issues downstream.

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Researchers have achieved a breakthrough in zero-field nuclear magnetic resonance spectroscopy, paving the way towards benchmarking quantum chemistry calculations.

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Dense E.coli bacteria have several similar qualities to colloidal glass. Colloids are substances made up of small particles suspended within a fluid, like ink for example. When these particles become higher in density and more packed together, they form a 'glassy state.' When researchers multiplied E.coli bacteria within a confined area, they found that they exhibited similar characteristics. More surprisingly, they also showed some other unique properties not typically found in glass-state materials. This study contributes to our understanding of glassy 'active matter,' a relatively new field of materials research which crosses physics and life science. In the long term, the researchers hope that these results will contribute to developing materials with new functional capabilities, as well as aiding our understanding of biofilms (where microorganisms stick together to form layers on surfaces) and natural bacterial colonies.

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Researchers discover how proteins behave inside cells using AI, which has the potential to guide drug design.

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Neuroprostheses allow the nervous system of a patient who has suffered an injury to connect with mechanical devices that replace paralyzed or amputated limbs. A study demonstrates in animal models how EGNITE, a derivative of graphene, allows the creation of smaller electrodes, which can interact more selectively with the nerves they stimulate, thus improving the efficacy of the prostheses.

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Researchers discovered a microscopic mechanism that solves in part the outstanding performance achieved by a new class of organic semiconductors known as non-fullerene acceptors (NFAs).

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Awarded the 2023 Nobel Prize in Chemistry, quantum dots have a wide variety of applications ranging from displays and LED lights to chemical reaction catalysis and bioimaging. These semiconductor nanocrystals are so small -- on the order of nanometers -- that their properties, such as color, are size dependent, and they start to exhibit quantum properties. This technology has been really well developed, but only in the visible spectrum, leaving untapped opportunities for technologies in both the ultraviolet and infrared regions of the electromagnetic spectrum.

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Certain types of light have proven to be an effective, minimally invasive treatment for cancers located on or near the skin when combined with a light-activated drug. But deep-seated cancers have been beyond the reach of light's therapeutic effects. To change this, engineers and scientists have devised a wireless LED device that can be implanted. This device, when combined with a light-sensitive dye, not only destroys cancer cells, but also mobilizes the immune system's cancer-targeting response.

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Development of a new way to accurately measure human serum albumin (HSA) levels in people with chronic kidney disease has progressed in recent testing.

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A small molecule that naturally serves as a binding site for metals in enzymes also proves useful for separating certain rare earth metals from each other. In a proof of concept, the process extracts europium directly from fluorescent powder in used energy-saving lamps in much higher quantities than existing methods. The researchers are now working on expanding their approach to other rare earth metals. They are in the process of founding a start-up to put the recycling of these raw materials into practice.

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Ice in nature is surrounded by liquid most of the time, and therefore it is key to understand how ice and liquid interact. A new study has now directly observe the precise shape of ice at the interface between ice and liquid -- by using antifreeze and a refrigerated microscope.

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Is it possible to create a new class of materials from very different substances using the 'one-pot synthesis' approach? Chemists explain how they enable the synthesis of such novel materials.

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Researchers have developed a bioelectric device that can detect and classify new variants of coronavirus to identify those that are most harmful. It has the potential to do the same with other viruses, as well.