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Categories: Biology: Molecular, Space: Structures and Features

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The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

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A technology called cryo-electron microscopy enables scientists to see the atomic structure of biological molecules in high resolution. But to date, it has been ineffective for imaging small molecules. A team of biochemists devised a solution that makes it possible to hold small protein molecules in place while they're being imaged, which will enable cryo-EM to produce much clearer images of such molecules. The advance is significant because small and medium-sized protein molecules are an area of focus in research on potential new drugs for cancer and other diseases.

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A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development.

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Scientists mapped out the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems then used that knowledge to modify its structure and improve its accuracy.

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A newly discovered nearby supernova whose star ejected up to a full solar mass of material in the year prior to its explosion is challenging the standard theory of stellar evolution. The new observations are giving astronomers new insight into what happens in the final year prior to a star's death and explosion.

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The supermassive black hole at the heart of galaxy M87, made famous by the first picture of a black hole shadow, has yielded another first: the jet shooting out from the black hole has been confirmed to wobble, providing direct proof that the black hole is spinning.

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Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.

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The cell organelles known as 'peroxisomes' dispose toxic substances and fats in the human body, among other things, and, in doing so, they prevent serious illnesses. The 'Pex' group of proteins (peroxisomes biogenesis factors) keep these 'detox units' functioning properly -- and now researchers have shown, at the atomic level, how these highly complex processes proceed.

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In a new study, scientists have shown that sweeping molten oceans have a large influence on the observed properties of hot rocky Super-Earths, such as their size and evolutionary path.

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A new study of the intriguing TRAPPIST-1 exoplanetary system has demonstrated the complex interaction between the activity of the system's star and its planetary features.

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Scientists have discovered a simple and reliable test for signs of past or present life on other planets -- 'the holy grail of astrobiology.' Researchers report that, with 90% accuracy, their artificial intelligence-based method distinguished modern and ancient biological samples from those of abiotic origin.

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Astronomers have found a striking link between the amount of dust surrounding a supermassive black hole and the strength of the radio emission produced in extremely bright galaxies.

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With the launch of the James Webb Space Telescope, astronomers are now able to peer so far back in time that we are approaching the epoch where we think that the first galaxies were created. Throughout most of the history of the Universe, galaxies seemingly tend to follow a tight relation between how many stars they have formed, and how many heavy elements they have formed. But for the first time we now see signs that this relation between the amount of stars and elements does not hold for the earliest galaxies. The reason is likely that these galaxies simply are in the process of being created, and have not yet had the time to create the heavy elements.

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Galaxies from the early Universe are more like our own Milky Way than previously thought, flipping the entire narrative of how scientists think about structure formation in the Universe, according to new research.

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Researchers have made a significant finding in determining the genetic background of dilated cardiomyopathy in Dobermanns. This research helps us understand the genetic risk factors related to fatal diseases of the heart muscle and the mechanisms underlying the disease, and offers new tools for their prevention.

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Balanophora shed one third of its genes as it evolved into a streamlined parasitic plant -- an extreme degree of genome shrinkage even among parasites. Along the way this subtropical plant developed the ability to induce the host plant to grow into the parasite's own flesh -- forming chimeric organs that mix host and parasite tissues.

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Palaeontologists have discovered X-ray evidence of proteins in fossil feathers that sheds new light on feather evolution.

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Researchers have developed the first method to uncover the tasks that microRNAs perform in single cells. This is a huge improvement over existing state-of-the-art methods that require millions of cells and will for the first time allow researchers to study microRNAs in complex tissues such as brains.

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Newly developed ultra-low radiation cables reduce background noise for neutrino and dark matter detectors.

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To make a gene-editing tool more precise and easier to control, engineers split it into two pieces that only come back together when a third molecule is added.