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Categories: Chemistry: Organic Chemistry, Engineering: Robotics Research

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Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

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Inspired by what human liver enzymes can do, chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions are expected to be widely used in drug discovery and optimization, as well as in other chemistry-based industries.

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Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.

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A new robotic suction cup which can grasp rough, curved and heavy stone, has been developed by scientists.

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Researchers are targeting the next generation of soft actuators and robots with an elastomer-based ink for 3D printing objects with locally changing mechanical properties, eliminating the need for cumbersome mechanical joints.

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Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult to make. A recent study demonstrates that soft skin pads doubling as sensors made from thermoplastic urethane can be efficiently manufactured using 3D printers.

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A new hybrid layered perovskite featuring elusive spontaneous defect ordering has been found, report scientists. By introducing specific concentrations of thiocyanate ions into FAPbI3 (FA = formamidinium), they observed that ordered columnar defects appeared in the stacked crystalline layers, taking up one-third of the lattice space. These findings could pave the way to an innovative strategy for adjusting the properties of hybrid perovskites, leading to practical advances in optoelectronics and energy generation.

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More than five million central lines are placed in patients who need prolonged drug delivery, such as those undergoing cancer treatments, in the United States every year, yet the common procedure can lead to a bevy of complications in almost a million of those cases. Researchers developed a robotic simulation training program to provide trainee physicians with more practice on the procedure. A year after deploying the program the team found that all complication types -- mechanical issues, infections and blood clots -- were significantly lower.

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A researcher who made color history in 2009 with a vivid blue pigment has developed durable, reddish magentas inspired by lunar mineralogy and ancient Egyptian chemistry.

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The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate. Scientists have devised a solution: Cas13d-NCS. This new molecular tool allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses. This advancement opens doors for precision medicine and proactive viral defense strategies.

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While there's no regulation in the U.S. for what's in organic shampoos, they tend to contain ingredients perceived as safe or environmentally friendly. However, these 'clean' shampoos separate and spoil faster than those made with synthetic stabilizers and preservatives. Now, researchers demonstrate that a simple process -- spinning organic shampoo at high speeds -- improved the final products' shelf lives and ability to clean hair.

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New research is shedding light on one barrier to a clean energy future: corrosion. Using nanoscale imaging techniques, researchers have captured high-resolution videos of tiny crystals of ruthenium dioxide -- a key ingredient used to produce clean-burning hydrogen -- as they are eaten away by their acidic environment. The research could pave the way to more durable catalysts and dramatically extend the lifetime of devices needed to turn hydrogen green.

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Star Trek's Holodeck is no longer just science fiction. Using AI, engineers have created a tool that can generate 3D environments, prompted by everyday language.

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Chemists show that a machine-based method prevents widespread 'bias' in chemical publications.

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Engineers designed modular, spring-like devices to maximize the work of live muscle fibers so they can be harnessed to power biohybrid robots.

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A new molecular test method helps to prove the authenticity of works of art. The new method could also help to make passwords secure against quantum computers.

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The active ingredient in many drugs is what's known as a small molecule: bigger than water, much smaller than an antibody and mainly made of carbon. It's tough, however, to make these molecules if they require a quaternary carbon -- a carbon atom bonded to four other carbon atoms. But now, scientists have uncovered a potential cost-effective way to produce these tricky motifs.

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Researchers gave nanorobots a trait called adaptive time delay, which allows them to better work together.

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Researchers have developed a programmable meta-fluid with tunable springiness, optical properties, viscosity and even the ability to transition between a Newtonian and non-Newtonian fluid. The first-of-its-kind meta-fluid uses a suspension of small, elastomer spheres -- between 50 to 500 microns -- that buckle under pressure, radically changing the characteristics of the fluid. The meta-fluid could be used in everything from hydraulic actuators to program robots, to intelligent shock absorbers that can dissipate energy depending on the intensity of the impact, to optical devices that can transition from clear to opaque.

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There is room for just one small bottle in the world's first refrigerator that is cooled with artificial muscles made of nitinol, a nickel-titanium alloy. But the mini-prototype is groundbreaking: it shows that elastocalorics is becoming a viable solution for practical applications. This climate-friendly cooling and heating technology is far more energy-efficient and sustainable than current methods.