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Categories: Chemistry: Biochemistry, Computer Science: General

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Researchers used structured light and switchable fluorescent molecules to reduce the background light from the out-of-plane regions of microscope samples. This method allowed for the acquisition of images that surpassed the conventional resolution limit, and it may be useful for further study of cell clusters and other biological systems.

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Physicists have shown that ultra-thin two-dimensional materials such as tungsten diselenide can rotate the polarization of visible light by several degrees at certain wavelengths under small magnetic fields suitable for use on chips.

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Inspired by what human liver enzymes can do, chemists have developed a new set of copper-catalyzed organic synthesis reactions for building and modifying pharmaceuticals and other molecules. The new reactions are expected to be widely used in drug discovery and optimization, as well as in other chemistry-based industries.

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Researchers have unveiled a new means of predicting how to synthesize new materials via the ion-exchange. Based on computer simulations, the method significantly reduces the time and energy required to explore for inorganic materials.

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Observing proteins precisely within cells is extremely important for many branches of research but has been a significant technical challenge -- especially in living cells, as the required fluorescent labeling had to be individually attached to each protein. The research group has now overcome this hurdle: With a method called 'vpCells,' it is possible to label many proteins simultaneously, using five different fluorescent colors.

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A new robotic suction cup which can grasp rough, curved and heavy stone, has been developed by scientists.

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A new typing model simulates the typing process instead of just predicting words.

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Scientists have discovered that the magnetic nanobubbles known as skyrmions can be moved by electrical currents, attaining record speeds up to 900 m/s. Anticipated as future bits in computer memory, these nanobubbles offer enhanced avenues for information processing in electronic devices. Their tiny size provides great computing and information storage capacity, as well as low energy consumption. Until now, these nanobubbles moved no faster than 100 m/s, which is too slow for computing applications. However, thanks to the use of an antiferromagnetic material as medium, the scientists successfully had the skyrmions move 10 times faster than previously observed. These results offer new prospects for developing higher-performance and less energy-intensive computing devices.

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Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult to make. A recent study demonstrates that soft skin pads doubling as sensors made from thermoplastic urethane can be efficiently manufactured using 3D printers.

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A new hybrid layered perovskite featuring elusive spontaneous defect ordering has been found, report scientists. By introducing specific concentrations of thiocyanate ions into FAPbI3 (FA = formamidinium), they observed that ordered columnar defects appeared in the stacked crystalline layers, taking up one-third of the lattice space. These findings could pave the way to an innovative strategy for adjusting the properties of hybrid perovskites, leading to practical advances in optoelectronics and energy generation.

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While the electronic tongue bears little physical resemblance to its namesake, the strand-like sensory probes of the 'e-tongue' still outperformed human senses when detecting contaminated wine in a recent study. In a recent experiment, the e-tongue identified signs of microorganisms in white wine within a week after contamination -- four weeks before a human panel noticed the change in aroma. This was also before those microbes could be grown from the wine in a petri-dish. Winemakers traditionally rely on these two methods, sniffing the wine and petri-dish testing, to identify potential wine 'faults' or spoilage.

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Engineers have developed a record-setting nanomaterial which when stretched in one direction, expands perpendicular to the applied force.

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In an approach they call 'nanostitching,' engineers used carbon nanotubes to prevent cracking in multilayered composites. The advance could lead to next-generation airplanes and spacecraft.

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Tagging marine animals with sensors to track their movements and ocean conditions can provide important environmental and behavioral information. Existing techniques to attach sensors currently largely rely on invasive physical anchors, suction cups, and rigid glues. While these techniques can be effective for tracking marine animals with hard exoskeletons and large animals such as sharks, individuals can incur physiological and metabolic stress during the tagging process, which can affect the quality of data collection. A newly developed soft hydrogel-based bioadhesive interface for marine sensors, referred to as BIMS, holds promise as an effective, rapid, robust, and non-invasive method to tag and track all sorts of marine species, including soft and fragile species. The BIMS tagging, which is also simple and versatile, can help researchers better understand animal behavior while also capturing oceanographic data critical for helping to better understand some impacts of climate change and for resource management.

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Simulations on the Stampede2 supercomputer of the Texas Advanced Computing Center (TACC) are helping scientists engineer solutions to overheating of grid transformers -- a critical component of the electric grid.

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Researchers adapt a novel force measurement technique to uncover the previously unidentified physics at play at the thin air-film gap between water droplets and superhydrophobic surfaces.

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Researchers found that a new activator called L687 induces cancer cells to accept delivery of antisense oligonucleotide (ASO) drugs. These drugs can treat cancer by blocking the transfer of messages from genes that encourage cancer growth. Previous methods to deliver ASOs into cells had only limited success. This research will help accelerate the development and delivery of novel ASO cancer therapies.

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4.5 million gamers around the world have advanced medical science by helping to reconstruct microbial evolutionary histories using a minigame included inside the critically and commercially successful video game, Borderlands 3. Their playing has led to a significantly refined estimate of the relationships of microbes in the human gut. The results of this collaboration will both substantially advance our knowledge of the microbiome and improve on the AI programs that will be used to carry out this work in future.

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Researchers analyzed the effects of solvation and ion valency on metallopolymers, with implications for critical materials recovery and recycling, and environmental remediation.

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The rise of RNA viruses like SARS-CoV-2 highlights the need for new ways to fight them. RNA-targeting tools like CRISPR/Cas13 are powerful but inefficient in the cytoplasm of cells, where many RNA viruses replicate. Scientists have devised a solution: Cas13d-NCS. This new molecular tool allows CRISPR RNA molecules that are located within the nucleus of a cell to move to the cytoplasm, making it highly effective at neutralizing RNA viruses. This advancement opens doors for precision medicine and proactive viral defense strategies.