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Categories: Mathematics: Modeling, Offbeat: Paleontology and Archeology

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A new artificial intelligence model can predict how different proteins may bind to DNA.

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Machine learning is a powerful tool in computational biology, enabling the analysis of a wide range of biomedical data such as genomic sequences and biological imaging. But when researchers use machine learning in computational biology, understanding model behavior remains crucial for uncovering the underlying biological mechanisms in health and disease. Researchers now propose guidelines that outline pitfalls and opportunities for using interpretable machine learning methods to tackle computational biology problems.

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An archaeological strategy adapted for space used daily photos to reveal how astronauts actually use areas aboard the International Space Station -- and how this differs from intended uses.

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Mammoths, the massive pre-historic ice age cousins of the modern-day elephant, have always been understood to have inhabited parts of British Columbia, but the question of when has always been a bit woolly. Now, a new study has given scientists the clearest picture yet when the giant mammals roamed Vancouver Island.

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The first-ever archeological survey in space has provided new insights into how astronauts use and adapt their living space on the International Space Station, which could influence the design of new space stations after the ISS is decommissioned.

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To protect the Amazon and support the wellbeing of its people, its economy needs to shift from environmentally harmful production to a model built around the diversity of indigenous and rural communities, and standing forests.

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Markings on a stone pillar at a 12,000 year-old archaeological site in Turkey likely represent the world's oldest solar calendar, created as a memorial to a devastating comet strike, experts suggest.

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A new study reports the discovery of extremely rare early human fossils from the Indonesian island of Flores, including an astonishingly small adult limb bone. Dated to about 700,000 years old, the new findings shed light on the evolution of Homo floresiensis, the so-called 'Hobbits' of Flores whose remains were uncovered in 2003 at Liang Bua cave in the island's west.

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The Pyramid of Djoser, the oldest of Egypt's iconic pyramids, may have been built with the help of a unique hydraulic lift system, according to researchers. A new study suggests that water may have been able to flow into two shafts located inside the pyramid itself, where that water could have been used to help raise and lower a float used to carry the building stones.

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With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome. GROVER treats human DNA as a text, learning its rules and context to draw functional information about the DNA sequences.

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Exceptional fossils with preserved soft parts reveal that the earliest mollusks were flat, armored slugs without shells. The new species, Shishania aculeata, was covered with hollow, organic, cone-shaped spines. The fossils preserve exceptionally rare detailed features which reveal that these spines were produced using a sophisticated secretion system that is shared with annelids (earthworms and relatives).

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Thermometer, a new calibration technique tailored for large language models, can prevent LLMs from being overconfident or underconfident about their predictions. The technique aims to help users know when a model should be trusted.

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A new study places the origin of the Imazighen in the Epipaleolithic, more than twenty thousand years ago. The research concludes that the genetic origin of the current Arab population of north Africa is far more recent than previously believed, placing it in the seventh century AD. The team has designed an innovative demographic model that uses artificial intelligence to analyze the complete genomes of the two populations.

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What if the 'Market Economy' always existed? Archaeologists tried to answer this question by researching how much Bronze Age people used to spend to sustain their daily lives. Their results show that, starting at least 3,500 years ago, the spending habits of prehistoric Europeans were not substantially different from what they are today.

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Clean energy investments offer potential stability and growth, especially during volatile market conditions. A recent study explored the relationship between clean energy markets and global stock markets. Significant spillovers were observed from major indices like the SP500 to markets such as Japan's Nikkei225 and Global Clean Energy Index. These interactions suggest opportunities for optimizing investment portfolios and leveraging clean energy assets as hedging tools in volatile market environments.

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Researchers have found that training successive generations of generative artificial intelligence models on synthetic data gives rise to self-consuming feedback loops.

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Researchers argue that, in some situations where machine-learning models are used to allocate scarce resources or opportunities, randomizing decisions in a structured way may lead to fairer outcomes.

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Birds tend to be more colorful in the tropics, and scientists wanted to find out how they got there: if colorful feathers evolved in the tropics, or if tropical birds have brightly-colored ancestors that came to the region from somwhere else. Scientists built a database of 9,409 birds to explore the spread of color across the globe. They found that iridescent, colorful feathers originated 415 times across the bird tree of life, and in most cases, arose outside of the tropics -- and that the ancestor of all modern birds likely had iridescent feathers, too.

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Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.

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Danish Tycho Brahe was most famous for his contributions to astronomy. However, he also had a well-equipped alchemical laboratory where he produced secret medicines for Europe's elite.