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Categories: Chemistry: Organic Chemistry, Ecology: Extinction
Published An epigenome editing toolkit to dissect the mechanisms of gene regulation
(via sciencedaily.com) Original source A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation. This innovative approach will help to investigate the role of chromatin modifications in many biological processes, and to program desired gene activity responses, which may prove useful in disease settings.
Published Chemists produce new-to-nature enzyme containing boron
(via sciencedaily.com) Original source Chemists created an enzyme with boronic acid at its reactive center. This approach can produce more selective reactions with boron, and allows the use of directed evolution to improve its catalytic power.
Published Scientists find ancient, endangered lamprey fish in Queensland, 1400 km north of its previous known range
(via sciencedaily.com) Original source Scientists have confirmed the identity of an unusual, ancient and Endangered species of fish that is living in the coastal rivers of Queensland, about 1400 km north of where it was previously known to live.
Published Why is breaking down plant material for biofuels so slow?
(via sciencedaily.com) Original source Tracking individual enzymes during the breakdown of cellulose for biofuel production has revealed how several roadblocks slow this process when using plant material that might otherwise go to waste. The research may lead to new ways to improve the breakdown process and make the non-edible parts of plants and other plant waste, such as forestry residue, a more competitive source of biofuels.
Published 'Better than graphene' material development may improve implantable technology
(via sciencedaily.com) Original source Move over, graphene. There's a new, improved two-dimensional material in the lab. Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Now, researchers have made the material potentially more useful by imparting chirality -- or handedness -- on it, which could make for advanced sensors and implantable medical devices.
Published Bee body mass, pathogens and local climate influence heat tolerance
(via sciencedaily.com) Original source How well bees tolerate temperature extremes could determine their ability to persist in a changing climate. But heat tolerance varies between and within populations, so entomologists examined bee physical traits to understand how these traits interact with environmental conditions, pathogens and other factors.
Published Caterbot? Robatapillar? It crawls with ease through loops and bends
(via sciencedaily.com) Original source Engineers created a catapillar-shaped robot that splits into segments and reassembles, hauls cargo, and crawls through twisting courses.
Published High-pressure spectroscopy: Why 3,000 bars are needed to take a comprehensive look at a protein
(via sciencedaily.com) Original source Why 3,000 bars are needed to take a comprehensive look at a protein: Researchers present a new high-pressure spectroscopy method to unravel the properties of proteins' native structures.
Published Stony coral tissue loss disease is shifting the ecological balance of Caribbean reefs
(via sciencedaily.com) Original source A new study shows stony coral tissue loss disease is causing drastic changes in the Caribbean's population of corals, which is sure to disrupt the delicate balance of the ecosystem and threaten marine biodiversity and coastal economies.
Published New approach in the synthesis of complex natural substances
(via sciencedaily.com) Original source Many natural substances possess interesting characteristics, and can form the basis of new active compounds in medicine. Terpenes, for example, are a group of substances, some of which are already used in therapies against cancer, malaria or epilepsy. They are found as fragrances in cosmetics or as flavorings in food, and form the basis of new medications: Terpenes are natural substances that occur in plants, insects and sea sponges. They are difficult to produce synthetically. However, chemists are now introducing a new method of synthesis.
Published Researchers create new chemical compound to solve 120-year-old problem
(via sciencedaily.com) Original source Chemists have created a highly reactive chemical compound that has eluded scientists for more than 120 years. The discovery could lead to new drug treatments, safer agricultural products, and better electronics.
Published Feathers, cognition and global consumerism in colonial Amazonia
(via sciencedaily.com) Original source Amazonia is the home of the largest variety of birds in the world. In such a unique environment, craft cultures have flourished by translating the beauty and creativity of environmental materials like feathers into stunning pieces of art. A new article examines artisanal featherwork within the context of early modern colonialism and globalization.
Published Missing link in species conservation: Pharmacists, chemists could turn tide on plant, animal extinction
(via sciencedaily.com) Original source As the world faces the loss of a staggering number of species of animals and plants to endangerment and extinction, one scientist has an urgent message: Chemists and pharmacists should be key players in species conservation efforts.
Published Scientists solve chemical mystery at the interface of biology and technology
(via sciencedaily.com) Original source Organic electrochemical transistors (OECTs) allow current to flow in devices like implantable biosensors. But scientists long knew about a quirk of OECTs that no one could explain: When an OECT is switched on, there is a lag before current reaches the desired operational level. When switched off, there is no lag. Current drops immediately. Researchers report that they have discovered the reason for this activation lag, and in the process are paving the way to custom-tailored OECTs for a growing list of applications in biosensing, brain-inspired computation and beyond.
Published Protecting endangered monkeys from poachers, habitat loss
(via sciencedaily.com) Original source The 17 species of red colobus monkey living across Africa, including in the Tai Project field station region, have been singled out by scientists as a priority conservation target. Protection of these monkeys, they assert, can be expected to produce benefits throughout tropical African forests where hunting and climate change have led to dramatic wildlife and habitat loss.
Published Research on RNA editing illuminates possible lifesaving treatments for genetic diseases
(via sciencedaily.com) Original source The research explores how CRISPR can be used to edit RNA.
Published When does a conductor not conduct?
(via sciencedaily.com) Original source A new study uncovers a switchable, atomically-thin metal-organic material that could be used in future low-energy electronic technologies. The study shows that electron interactions in this material create an unusual electrically-insulating phase in which electrons are 'frozen'. By reducing the population of electrons, the authors are able to unfreeze the remaining electrons, allowing for controlled transitions between insulating and electrically-conductive phases: the key to the on-off binary operations of classical computing.
Published T. Rex not as smart as previously claimed
(via sciencedaily.com) Original source Dinosaurs were likely as smart as reptiles but not as intelligent as monkeys.
Published Getting dynamic information from static snapshots
(via sciencedaily.com) Original source Researchers have created TopicVelo, a powerful new method of using the static snapshots from scRNA-seq to study how cells and genes change over time. This will help researchers better study how embryos develop, cells differentiate, cancers form, and the immune system reacts.
Published A shortcut for drug discovery
(via sciencedaily.com) Original source For most human proteins, there are no small molecules known to bind them chemically (so called 'ligands'). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines. Researchers at CeMM, in a collaboration with Pfizer, have now leveraged and scaled a method to measure the binding activity of hundreds of small molecules against thousands of human proteins. This large-scale study revealed tens of thousands of ligand-protein interactions that can now be explored for the development of chemical tools and therapeutics. Moreover, powered by machine learning and artificial intelligence, it allows unbiased predictions of how small molecules interact with all proteins present in living human cells. These groundbreaking results have been published in the journal Science (DOI: 10.1126/science.adk5864), and all generated data and models are freely available for the scientific community.