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Categories: Chemistry: Biochemistry, Ecology: Animals

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Engineers have pioneered a new way to visualize the smallest protein clusters, skirting the physical limitations of light-powered microscopes and opening new avenues for detecting the proteins implicated in diseases like Alzheimer's and testing new treatments.

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A novel PET imaging technique can noninvasively detect active inflammation in the body before clinical symptoms arise, according to new research. Using a PET tracer that binds to proteins present on activated immune cells, the technique produces images of ongoing inflammation throughout the body, such as rheumatoid arthritis. This makes it easier for physicians to correctly diagnose and treat patients.

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A new fusion of materials, each with special electrical properties, has all the components required for a unique type of superconductivity that could provide the basis for more robust quantum computing.

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An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report. The organoids recapitulate hallmarks of pregestational diabetes-induced congenital heart disease found in mice and humans. The findings also showed that endoplasmic reticulum (ER) stress and lipid imbalance are critical factors contributing to these disorders, which could be ameliorated with exposure to omega-3s.

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The ability to detect diseases at an early stage or even predict their onset would be of tremendous benefit to doctors and patients alike. A research team now develops intelligent, miniaturized biosensor devices and systems using nanomaterials to determine biomolecules and cells as well as biochemical reactions or processes as disease markers. The team's current publication describes the development of a portable, palm-sized test system that can simultaneously carry out up to thirty-two analyses of one sample.

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Carboxylic acid dianions (fumarate, maleate and succinate) play a role in coordination chemistry and to some extent also in the biochemistry of body cells. A team has now analyzed their electronic structures using RIXS in combination with DFT simulations. The results provide information not only on electronic structures but also on the relative stability of these molecules which can influence an industry's choice of carboxylate dianions, optimizing both the stability and geometry of coordination polymers.

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An international research team has succeeded in controlling the chirality of individual molecules through structural isomerization. The team also succeeded in synthesizing highly reactive diradicals with two unpaired electrons. These achievements were made using a scanning tunneling microscope probe at low temperatures.

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Lithium-sulfur batteries have exceptional theoretical capacity and performance in combination with an element in abundant supply. But the intricate reaction mechanism, particularly during discharge, has been challenging to solve. Researchers have identified the key pathways to a complex sulfur reduction reaction that leads to energy loss and reduced battery life span. The study's findings establish the whole reaction network for the first time and offer insight into electrocatalyst design for improved batteries.

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In hydrogen fuel cells, electrolyte membranes frequently undergo deformation and develop cracks during operation. A research team has recently introduced a fatigue-resistant polymer electrolyte membrane for hydrogen fuel cells, employing an interpenetrating network of Nafion (a plastic electrolyte) and perfluoropolyether (a rubbery polymer). This innovation will not only improve fuel cell vehicles but also promises advancements in diverse technologies beyond transportation, spanning applications from drones to desalination filters and backup power sources.

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Researchers have developed a new biocontainment method for limiting the escape of genetically engineered organisms used in industrial processes.

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An experiment spanning more than two decades has found that removal of apex predators from an ecosystem can create lasting changes that are not reversed after they return -- at least, not for a very long time. The study challenges the commonly held belief that the reintroduction of wolves to Yellowstone National Park restored an ecosystem degraded by their absence.

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A crystals expert has published an answer to how crystals are formed and how molecules become a part of them, solving an age-old mystery about crystal formation.

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There was an increase in the number of unprovoked shark attacks worldwide and an uptick in fatalities in 2023 compared to the previous year. A scientific database of global shark attacks, confirmed 69 unprovoked bites in 2023. Although this is higher than the most recent five-year average of 63 attacks, the data remain consistent with long-term trends.

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Scientists have found a way to boost ethanol production via yeast fermentation, a standard method for converting plant sugars into biofuels. Their approach relies on careful timing and a tight division of labor among synthetic yeast strains to yield more ethanol per unit of plant sugars than previous approaches have achieved.

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Scientists have found soundwaves from low-intensity focused ultrasound aimed at a place deep in the brain called the insula can reduce both the perception of pain and other effects of pain, such as heart rate changes.

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The proverb "necessity is the mother of invention" has been used to describe the source from which our cultural evolution springs. After all, need in times of scarcity has forced humans to continually invent new technologies that have driven the remarkable cumulative culture of our species. But an invention only becomes cultural if it is learned and spread by many individuals. In other words, the invention must be socially transmitted. But what are the forces that drive social transmission?

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Researchers have developed a first-of-its-kind, handheld electrochemical sensor that can accurately detect fentanyl in urine within seconds. The proof-of-concept technology can detect even trace amounts of fentanyl with 98% accuracy using a small portable device without costly and time-consuming lab analysis.

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Engineers have developed an ultra-sensitive sensor made with graphene that can detect extraordinarily low concentrations of lead ions in water. The device achieves a record limit of detection of lead down to the femtomolar range, which is one million times more sensitive than previous technologies.

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Scientists developed a new method to map exactly how a fungus works with leafcutter ants in a complex microbial community to degrade plant material at the molecular level. The team's insights are important for biofuels development.

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It's an achievement with important implications for scientists studying the brain and working on treatments for a broad range of neurological and neurodevelopmental disorders, such as Alzheimer's and Parkinson's disease.