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Categories: Biology: General, Space: Exploration

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The placenta's response to infections from malaria, toxoplasmosis and listeria has been mapped in high resolution, possibly paving the way for new treatment options.

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Researchers have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide. The discovery may be important for future research into the treatment of certain diseases.

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Researchers describe a natural product-like molecule, Tantalosin, that inhibits interaction between two proteins in complexes that reshape membranes inside the cell. The findings lead to a deeper understanding of how membrane remodeling works in human cells and future development of new drugs.

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Some of the ocean's tiniest organisms get swept into underwater currents that act as a conduit that shuttles them from the sunny surface to deeper, darker depths where they play a huge role in affecting the ocean's chemistry and ecosystem, according to new research.

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Working with human breast and lung cells, scientists say they have charted a molecular pathway that can lure cells down a hazardous path of duplicating their genome too many times, a hallmark of cancer cells.

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Natural malaria infections have been genetically analysed at a higher resolution than ever before, giving insights that could help understand and block transmission.

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Researchers have found that a brain disorder associated with flu (influenza-associated encephalopathy, or IAE) can be caused by the influenza virus entering the brain from the blood via endothelial cells. In these cells, the researchers observed viral protein accumulation, suggesting that antivirals targeting viral transcription/translation may be useful treatments for some patients. Given the lack of effective treatments for IAE, this finding will likely improve patient care and reduce IAE-related deaths worldwide.

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Many natural substances possess interesting characteristics, and can form the basis of new active compounds in medicine. Terpenes, for example, are a group of substances, some of which are already used in therapies against cancer, malaria or epilepsy. They are found as fragrances in cosmetics or as flavorings in food, and form the basis of new medications: Terpenes are natural substances that occur in plants, insects and sea sponges. They are difficult to produce synthetically. However, chemists are now introducing a new method of synthesis.

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Researchers have deciphered the complex interplay of various enzymes around the innate immune receptor toll-like receptor 7 (TLR7), which plays an important role in defending our bodies against viruses.

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The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations, researchers report. Moreover, leukocyte telomere length (LTL) is negatively associated with malaria endemicity and only partly explained by genetic factors.

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Researchers discovered a concerning association between bacteremia and probiotic use, particularly with Clostridium butyricum (C. butyricum) MIYAIRI 588. Whole-genome sequencing revealed that all C. butyricum bacteremia strains were probiotic derivatives. Out of 6,576 cases of positive blood cultures, C. butyricum was detected in only five cases, all derived from probiotics. The study underscores rare but serious adverse events linked to probiotics, advocating cautious prescribing practices, especially for hospitalized patients.

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Recent reports of NASA's James Webb Space Telescope finding signs of life on a distant planet understandably sparked excitement. A new study challenges this finding, but also outlines how the telescope might verify the presence of the life-produced gas.

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A parasite that not only feeds of its host, but also makes the host change its own metabolism and thus biology. Microbiologists have shown this for the very first time in a specific group of parasitic microbes, so-called DPANN archea. Their study shows that these archaea are very 'picky eaters', which might drive their hosts to change the menu.

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Viruses known as 'jumbo' phages are seen as a potential tool against deadly bacterial infections. But scientists must first decipher the extraordinary makeup of these mysterious viruses. Researchers have now uncovered a key piece of jumbo phage development that helps them counter bacteria.

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Scientists are harnessing cells to make new types of materials that can grow, repair themselves and even respond to their environment. These solid 'engineered living materials' are made by embedding cells in an inanimate matrix that's formed in a desired shape. Now, researchers have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.

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A research team using the ChemCam instrument onboard NASA's Curiosity rover discovered higher-than-usual amounts of manganese in lakebed rocks within Gale Crater on Mars, which indicates that the sediments were formed in a river, delta, or near the shoreline of an ancient lake.

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For the first time since 1914, a new species of the Japanese lily known as sukashiyuri has been identified. A research team analyzed the morphology and DNA of these lilies and has revised the conventional classification from four taxonomic groups to eight.

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Conventional plant regeneration approaches by cell culture require the external application of plant growth regulators, including hormones. However, optimizing culture conditions can be laborious. Now, researchers have developed a novel plant regeneration system that omits the need for hormone application by genetically regulating the expression of genes that control plant cell differentiation. Their work holds significant potential in the development of genetically modified plants in a simpler and cost-effective manner.

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As the world faces the loss of a staggering number of species of animals and plants to endangerment and extinction, one scientist has an urgent message: Chemists and pharmacists should be key players in species conservation efforts.

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NASA's James Webb Space Telescope has captured the sharpest infrared images to date of a zoomed-in portion of one of the most distinctive objects in our skies, the Horsehead Nebula. These observations show the top of the 'horse's mane' or edge of this iconic nebula in a whole new light, capturing the region's complexity with unprecedented spatial resolution.