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Categories: Biology: Developmental, Energy: Nuclear

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A team deciphers complicated mechanism underlying genetic diversity.

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For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.

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Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.

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A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus. A new study has uncovered how this microbial combination manipulates sperm, which could lead to refined techniques to control populations of agricultural pests and insects that carry diseases like Zika and dengue to humans.

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All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.

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A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity.

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An updated method for directly observing physical interactions between cells, could allow scientists to one day map every possible cell interaction.

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'Random DNA' is naturally active in the one-celled fungi yeast, while such DNA is turned off as its natural state in mammalian cells, despite their having a common ancestor a billion years ago and the same basic molecular machinery, a new study finds.

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Epigenetic changes play important roles in cancer, metabolic and aging-related diseases, but also during loss of resilience as they cause the genetic material to be incorrectly interpreted in affected cells. A major study now provides important new insights into how complex epigenetic modification signatures regulate the genome. This study will pave the way for new treatments of diseases caused by faulty epigenetic machineries.

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Researchers developed protocols for growing organoids that mimic a turtle liver, the first organoids developed for a turtle and only the second for any reptile. The discovery will aid deeper study of turtle genetics, including the cause of traits with potential medical applications for humans such as the ability to survive weeks without oxygen.

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Scientists are embracing imperfection, using less-than-ideal magnetic fields to make the plasma more manageable.

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A globally distributed single-celled organism that occurs in harmful algal blooms has been found to exhibit an unusual organisation of photosynthesis. Researchers have taken a closer look at the unusual cell biology of the species Prorocentrum cordatum from the group of dinoflagellates. The results of their study could help to better understand the role of the species in the environment and the increased occurrence of algal blooms at higher water temperatures.

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A new paper examines the possible effects of two properties of receiver playing fields documented in studies of animal psychology -- habituation and neural adaptation -- on the efficacy of mate choice signals.

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Keratin microsphere gel, consisting of keratin-based microspheres that swell in water to form a gel, has shown efficacy in promoting hair follicle growth in murine models. Its potential application as an active ingredient in hair regrowth treatments with minimal side effects is anticipated.

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Researchers report that the Golgi ribbon, an organelle structure previously thought to be exclusive to vertebrates, is also present in animal taxa, including mollusks, earthworms, and sea urchins. The function of the Golgi ribbon is still enigmatic, but its presence in diverse animal lineages indicates that its function is not vertebrate specific, as previously thought. The team also showed Golgi ribbons form at a specific timepoint during embryogenesis, which suggests that they might play a role in cell differentiation.

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Scientists have found a new way to alter the DNA of bacterial cells -- a process used to make many vital medicines including insulin -- much more efficiently than standard industry techniques.

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New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought.

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A genetic change in our ancient ancestors may partly explain why humans don't have tails like monkeys.

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Decoding the conversations between microbes of hypersaline environments reveals deep insights into the origins of complex life.

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The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists.