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Categories: Biology: Developmental, Engineering: Graphene
Published Heart repair via neuroimmune crosstalk
(via sciencedaily.com) Original source Unlike humans, zebrafish can completely regenerate their hearts after injury. They owe this ability to the interaction between their nervous and immune systems, as researchers now report.
Published Genomic tug of war could boost cancer therapy
(via sciencedaily.com) Original source Researchers have discovered a 'genomic tug of war' in animal studies that could influence how well certain patients -- or certain cancers -- respond to decitabine, a drug used to treat myelodysplastic syndromes that is plagued by drug resistance issues. For the first time, researchers show that decitabine causes coding and non-coding regions of DNA to engage in a tug of war for a gene activator, called H2A.Z. Typically, deticabine draws this gene activator away from coding DNA, causing gene expression to grind to a halt and cells to die. However, many types of cancer have very high levels of H2A.Z, which may help them overcome this decitabine-induced tug of war, allowing the cancer to grow.
Published How cell identity is preserved when cells divide
(via sciencedaily.com) Original source A new theoretical model helps explain how epigenetic memories, encoded in chemical modifications of chromatin, are passed from generation to generation. Within each cell's nucleus, researchers suggest, the 3D folding patterns of its genome determines which parts of the genome will be marked by these chemical modifications.
Published Much more than waste: Tiny vesicles exchange genetic information between cells in the sea
(via sciencedaily.com) Original source Researchers take a look at data that has so far been mostly discarded as contamination, revealing the previously underestimated role of extracellular vesicles (EVs). These are important for the exchange of genetic information between cells and thus for the microbial community in the sea.
Published Riddle of Kondo effect solved in ultimately thin wires
(via sciencedaily.com) Original source A research team has now directly measured the so-called Kondo effect, which governs the behavior of magnetic atoms surrounded by a sea of electrons: New observations with a scanning tunneling microscope reveal the effect in one-dimensional wires floating on graphene.
Published Novel C. diff structures are required for infection, offer new therapeutic targets
(via sciencedaily.com) Original source Newly discovered iron storage 'ferrosomes' inside the bacterium C. diff -- the leading cause of hospital-acquired infections -- are important for infection in an animal model and could offer new targets for antibacterial drugs. They also represent a rare demonstration of a membrane-bound structure inside a pathogenic bacterium, upsetting the biological dogma that bacteria do not contain organelles.
Published New discovery on how green algae count cell divisions illuminates key step needed for the evolution of multicellular life
(via sciencedaily.com) Original source An international research team has made an unexpected discovery of a biased counting mechanism used by the single-celled green alga Chlamydomonas to control cell division.
Published Template for success: Shaping hard carbon electrodes for next-generation batteries
(via sciencedaily.com) Original source Sodium- and potassium-ion batteries are promising next-generation alternatives to the ubiquitous lithium-ion batteries (LIBs). However, their energy density still lags behind that of LIBs. To tackle this issue, researchers explored an innovative strategy to turn hard carbon into an excellent negative electrode material. Using inorganic zinc-based compounds as a template during synthesis, they prepared nanostructured hard carbon, which exhibits excellent performance in both alternative batteries.
Published The Goldilocks Effect: Researchers establish framework for protein regulation
(via sciencedaily.com) Original source Researchers are working to understand how protein quality control works in cells.
Published Yeast cells can produce drugs for treatment of psychotic disorders
(via sciencedaily.com) Original source An international team of researchers has demonstrated that genetically engineered yeast cells can produce the natural plant product alstonine, which has shown positive effects in treating schizophrenia.
Published Team creates synthetic enzymes to unravel molecular mysteries
(via sciencedaily.com) Original source A bioengineer has developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in the development of muscle, bone and blood in vertebrate embryos. The team of researchers is using a new approach, called the Synthetic Processing (SynPro) system, in zebrafish to study how Vg1 is formed. By learning the molecular rules of signal formation in a developing animal, researchers aim to engineer mechanisms -- such as giving cells new instructions -- that could play a role in treating or preventing disease.
Published Scientists use quantum biology, AI to sharpen genome editing tool
(via sciencedaily.com) Original source Scientists used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.
Published First live birth of a chimeric monkey using embryonic stem cell lines
(via sciencedaily.com) Original source A team of researchers has reported for the first time the live birth of a monkey that contains a high proportion of cells derived from a monkey stem cell line. This 'chimeric' monkey is composed of cells that originate from two genetically distinct embryos of the same species of monkey. This has previously been demonstrated in rats and mice but, until now, has not been possible in other species, including non-human primates.
Published Zen and the art of mitochondrial maintenance: The machinery of death makes a healthier life
(via sciencedaily.com) Original source While we all aspire for a long lifespan, what is most coveted is a long period of vigor and health, or 'healthspan,' that precedes the inevitable decline of advancing age. Researchers have discovered that instruments of death that cells use to commit suicide when things go wrong contribute to making a longer and healthier life by revitalizing the specialized cellular compartments called mitochondria.
Published Temperature increase triggers viral infection
(via sciencedaily.com) Original source Researchers have mapped on an atomic level what happens in a virus particle when the temperature is raised.
Published How animals get their stripes and spots
(via sciencedaily.com) Original source New research helps explain how sharp patterns form on zebras, leopards, tropical fish and other creatures. Their findings could inform the development of new high-tech materials and drugs.
Published Yeast with an over half synthetic genome is created in the lab
(via sciencedaily.com) Original source Researchers have combined over seven synthetic chromosomes that were made in the lab into a single yeast cell, resulting in a strain with more than 50% synthetic DNA that survives and replicates similarly to wild yeast strains. A global consortium is working to develop the first synthetic eukaryote genome from scratch. The team has now synthesized and debugged all sixteen yeast chromosomes.
Published Scientists take major step towards completing the world's first synthetic yeast
(via sciencedaily.com) Original source A team of Scientists has completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome. The work represents completion of one of the 16 chromosomes of the yeast genome, which is part of the biggest project ever in synthetic biology; the international synthetic yeast genome collaboration. The collaboration, known as 'Sc2.0' has been a 15-year project involving teams from around the world (UK, US, China, Singapore, UK, France and Australia), working together to make synthetic versions of all of yeast's chromosomes. Alongside this paper, another 9 publications are also released today from other teams describing their synthetic chromosomes. The final completion of the genome project -- the largest synthetic genome ever -- is expected next year.
Published Obesity linked to neurodegeneration through insulin resistance
(via sciencedaily.com) Original source Researchers have discovered a link between obesity and neurodegenerative disorders like Alzheimer's disease. Using the common fruit fly, the research shows that a high-sugar diet -- a hallmark of obesity -- causes insulin resistance in the brain, which in turn reduces the ability to remove neuronal debris, thus increasing the risk of neurodegeneration.
Published Video technology could transform how scientists monitor changes in species evolution and development
(via sciencedaily.com) Original source New research combines microscope and video technology to analyze how different species develop, and how changes in the timings of any developments can be tracked. A detailed analysis of the Energy Proxy Traits (EPTs) that result from these processes has provided researchers with the first evidence that traditionally measured timings of developmental events are associated with far broader changes to the full set of an embryo's observable characteristics.