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Categories: Biology: Developmental, Engineering: Graphene

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The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

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The friction on a graphene surface can be dynamically tuned using external electric fields, according to researchers.

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Some substances in medicines, household items and the environment are known to affect prenatal child development. Researchers tested the effects of five drugs (including caffeine and the blood thinner warfarin) on the growth of zebrafish embryos. They found that all five had the same effect, impairing the migration of bone-forming cells which resulted in the onset of facial malformation. Zebrafish embryos grow quickly, are transparent and develop outside of the parent's body, making them ideal for studying early development. A zebrafish-based system could be used to easily screen for potentially harmful substances, reducing animal testing on mammals and supporting parents-to-be when making choices for themselves and their baby.

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Brain circuits for vision develop without any kind of input from the retina in zebrafish.

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A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development.

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Scientists mapped out the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems then used that knowledge to modify its structure and improve its accuracy.

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Researchers discover that heart cells in developing zebrafish start beating suddenly and all at once

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Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.

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Even without a central brain, jellyfish can learn from past experiences like humans, mice, and flies, scientists report for the first time. They trained Caribbean box jellyfish (Tripedalia cystophora) to learn to spot and dodge obstacles. The study challenges previous notions that advanced learning requires a centralized brain and sheds light on the evolutionary roots of learning and memory.

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A research team has successfully developed a new method that can prevent the crossover of large fuel molecules and suppress the degradation of electrodes in advanced fuel cell technology using methanol or formic acid. The successful sieving of the fuel molecules is achieved via selective proton transfers due to steric hindrance on holey graphene sheets that have chemical functionalization and act as proton-exchange membranes.

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Researchers have developed the first method to uncover the tasks that microRNAs perform in single cells. This is a huge improvement over existing state-of-the-art methods that require millions of cells and will for the first time allow researchers to study microRNAs in complex tissues such as brains.

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In a new study in mice, researchers have uncovered a crucial component for restoring functional activity after spinal cord injury. The neuroscientists have shown that re-growing specific neurons back to their natural target regions led to recovery, while random regrowth was not effective.

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Researchers created nanoribbons made of phosphorus and tiny amounts of arsenic, which they found were able to conduct electricity at temperatures above -140 degrees Celsius, while retaining the highly useful properties of the phosphorus-only ribbons.

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How do our muscles respond at the molecular level to exercise? Researchers have unraveled the cellular basis and signaling pathways responsible for the positive impact of physical activity on our overall health. Regulatory T cells, a type of immune cell, play a critical role in ensuring proper muscle function. These novel insights are paving the path towards precision medicines targeting metabolic disorders like obesity and diabetes, as well as muscle-related illnesses.

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Researchers have developed a method of 'wiring up' graphene nanoribbons (GNRs), a class of one-dimensional materials that are of interest in the scaling of microelectronic devices. Using a direct-write scanning tunneling microscopy (STM) based process, the nanometer-scale metal contacts were fabricated on individual GNRs and could control the electronic character of the GNRs. The researchers say that this is the first demonstration of making metal contacts to specific GNRs with certainty and that those contacts induce device functionality needed for transistor function.

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Researchers have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.

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A research team has achieved a significant breakthrough in the development of a hybrid silicon photocatalyst.

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A new study sheds new light on the origins of modern brain cells. Researchers find evidence that specialized secretory cells found in placozoans, tiny sea creatures the size of a grain of sand, have many similarities to the neuron, such as the genes required to create a partial synapse. From an evolutionary point of view, early neurons might have started as something like these cells, eventually gaining the ability to create a complete synapse, form axons and dendrites and create ion channels that generate fast electrical signals -- innovations which gave rise to the neuron in more complex animals such as jellyfish. Though the complete story of how the first neuron appeared remains to be told, the study demonstrates that the basic building blocks for our brain cells were forming in the ancestors of placozoans grazing inconspicuously in the shallow seas of Earth around 800 million years ago.

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Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.

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Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.