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Categories: Biology: Developmental, Space: Structures and Features
Published New deep learning model is 'game changer' for measuring embryo development
(via sciencedaily.com) Original source A new deep learning model performs a task that biologists have struggled with for centuries -- how to measure the incredibly complex process of embryonic development. Scientists have shown that the AI model, known as Dev-ResNet, can identify what happens and when during embryonic development, from video. While used in pond snail embryos for this study, in future the technique could be used to help accelerate understanding on how climate change, and other external factors, affect humans and animals in the earliest stages of life.
Published Mechanisms for selective multiple sclerosis treatment strategy
(via sciencedaily.com) Original source Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.
Published Genetic mosaicism more common than thought
(via sciencedaily.com) Original source Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.
Published Researchers have unveiled a new method to manipulate cell movement in embryos
(via sciencedaily.com) Original source Scientists have developed a new method that can manipulate the movement of embryonic cells using short-time attractors.
Published How killifish embryos use suspended animation to survive over 8 months of drought
(via sciencedaily.com) Original source The African turquoise killifish lives in ephemeral ponds in Zimbabwe and Mozambique. To survive the annual dry season, the fish's embryos enter a state of extreme suspended animation or 'diapause' for approximately 8 months. Now, researchers have uncovered the mechanisms that enabled the killifish to evolve this extreme survival state.
Published Investigating the origin of circatidal rhythms in freshwater snails
(via sciencedaily.com) Original source While most organisms have biological clocks synchronized with the day-night cycle (circadian rhythms), marine animals in tidal areas have also developed circatidal rhythms to align with the tidal cycle. Comparing the activity and genetic expression of snails from tidal and non-tidal areas, researchers demonstrate that circatidal rhythms develop as snails adapt to tidal environments. These findings highlight the flexibility of biological clocks, enabling organisms to adjust their rhythms according to the environment.
Published Birth of universe's earliest galaxies observed for first time
(via sciencedaily.com) Original source Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.
Published New 'atlas' provides unprecedented insights on how genes function in early embryo development
(via sciencedaily.com) Original source Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers captured unprecedented insights on how embryonic development unfolds.
Published Birdsong and human voice built from same genetic blueprint
(via sciencedaily.com) Original source Humans have been long fascinated by bird song and the cacophony of other avian sounds -- from coos and honks to quacks and peeps. But little is known about how the unique vocal organ of birds -- the syrinx -- varies from species to species or its deeper evolutionary origins. A trio of recent studies is changing that. The studies include high-resolution anatomical scans of syrinxes from hummingbirds and ostriches -- the world's smallest and largest bird species -- and the discovery that the syrinx and larynx, the vocal organ of reptiles and mammals, including humans, share the same developmental programming.
Published Intriguing nearby world sized between Earth, Venus
(via sciencedaily.com) Original source Astronomers have discovered a planet between the sizes of Earth and Venus only 40 light-years away.
Published Planet hunters unveil massive catalog of strange worlds
(via sciencedaily.com) Original source While thousands of planets have been discovered around other stars, relatively little is known about them. A NASA catalog featuring 126 exotic, newly discovered worlds includes detailed measurements that allow for comparisons with our own solar system.
Published Novel approach to interrogate tissue-specific protein-protein interactions
(via sciencedaily.com) Original source Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial for cells to carry out their specific tasks and to form complex molecular machinery. However, our current understanding of such protein-protein interactions often lacks cellular contexts because they were usually studied in an in vitro system or in cells isolated from their tissue environment. Effective methods to investigate protein-protein interactions in a tissue-specific manner are largely missing.
Published First pictures from Euclid satellite reveal billions of orphan stars
(via sciencedaily.com) Original source The first scientific pictures from the Euclid satellite mission have revealed more than 1,500 billion orphan stars scattered throughout the Perseus cluster of galaxies.
Published Potentially habitable 'exo-Venus' with Earth-like temperature discovered
(via sciencedaily.com) Original source Astronomers have made the rare and tantalizing discovery of an Earth-like exoplanet 40 light-years away that may be just a little warmer than our own world. The potentially-habitable planet, named Gliese 12 b, orbits its host star every 12.8 days, is comparable in size to Venus -- so slightly smaller than Earth -- and has an estimated surface temperature of 42 C (107 F), which is lower than most of the 5,000-odd exoplanets confirmed so far. That is assuming it has no atmosphere, however, which is the crucial next step to establishing if it is habitable.
Published Tracking down the genetic causes of lupus to personalize treatment
(via sciencedaily.com) Original source Treatment of autoimmune diseases like lupus has long relied on steroids to knock down the immune system, but more targeted therapies are currently undergoing clinical trials. To make sure these therapies get to the patients who will benefit, work is needed to identify the specific mutations behind each patient's disease. Researchers now report several dozen mutations associated with oversensitive toll-like receptors -- a major cause of autoimmune disease -- and linked two mutations to patients.
Published Exploring diversity in cell division
(via sciencedaily.com) Original source Animals and fungi predominantly use two different modes of cell division -- called open and closed mitosis, respectively. A new study has shown that different species of Ichthyosporea -- marine protists that are close relatives of both animals and fungi -- use either open and closed mitosis, closely correlated to whether the species has multinucleate life cycle stages. The study demonstrates the way animals do cell division might have evolved long before animals themselves did and how this is linked to an organism's life cycle.
Published Sweet move: a modified sugar enhances antisense oligonucleotide safety and efficacy
(via sciencedaily.com) Original source Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.
Published Using wobbling stellar material, astronomers measure the spin of a supermassive black hole for the first time
(via sciencedaily.com) Original source Astronomers have a new way to measure how fast a black hole spins, by using the wobbly aftermath from its stellar feasting. The results offer a new way to probe supermassive black holes and their evolution across the universe.
Published New AI accurately predicts fly behavior
(via sciencedaily.com) Original source Researchers trained an AI model to accurately predict male fruit flies' courtship behavior in response to any sight of a female. This breakthrough offers new insight into how the brain processes visual data and may someday pave the way for artificial vision technology.
Published Study finds widespread 'cell cannibalism,' related phenomena across tree of life
(via sciencedaily.com) Original source Researchers describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoebas to complex multicellular animals.