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Categories: Biology: Developmental, Space: Structures and Features

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Astronomers have charted the largest-ever volume of the universe with a new map of active supermassive black holes living at the centers of galaxies. Called quasars, the gas-gobbling black holes are, ironically, some of the universe's brightest objects. The new map logs the location of about 1.3 million quasars in space and time, the furthest of which shone bright when the universe was only 1.5 billion years old. The work could help scientists better understand the properties of dark matter.

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The curvature of a surface determines the migration behavior of biological cells. They preferentially move along valleys or grooves while avoiding ridges. These findings gave rise to a model predicting cellular behavior. Such universal principles now allow a better understanding of the migration of immune and cancer cells, paving the way for new treatment options.

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Making a personalized T cell therapy for cancer patients currently takes at least six months. Scientists have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

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A new study challenges the current model of the universe by showing that, in fact, it has no room for dark matter.

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In examining the mating rituals of roundworms, researchers uncovered a unique approach to reproduction that maximizes genetic fitness.

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After the egg has been fertilized by a sperm, the surrounding egg coat tightens, mechanically preventing the entry of additional sperm and the ensuing death of the embryo, a new study finds. The work also explains how mutations in egg coat proteins can cause female infertility and may eventually lead to new contraceptive methods.

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Physicists often turn to the Rayleigh-Taylor instability to explain why fluid structures form in plasmas, but that may not be the full story when it comes to the ring of hydrogen clumps around supernova 1987A, research suggests. It looks like the same mechanism that breaks up airplane contrails might be at play in forming the clumps of hydrogen gas that ring the remnant of supernova 1987A.

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An unassuming brown bovine from the south of Brazil has made history as the first transgenic cow capable of producing human insulin in her milk. The advancement could herald a new era in insulin production, one day eliminating drug scarcity and high costs for people living with diabetes.

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Trabectedin, a promising drug derived from the sea squirt Ecteinascidia turbinata, has shown potential in combating cancers resistant to conventional treatments. However, its precise mechanism of action has remained elusive -- until now.

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The formation of stars and the chaotic environments they inhabit is one of the most well-studied, but also mystery-shrouded, areas of cosmic investigation. The intricacies of these processes are now being unveiled like never before by NASA's James Webb Space Telescope.

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Researchers have identified the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of sensory biology.

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New research describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos. The technique could be used by women of advanced maternal age or for those who are unable to produce viable eggs due to previous treatment for cancer or other causes. It also raises the possibility of men in same-sex relationships having children who are genetically related to both parents.

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Researchers have discovered a mechanism steering the evolution of multicellular life. They identified how altered protein folding drives multicellular evolution.

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A team deciphers complicated mechanism underlying genetic diversity.

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For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.

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Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.

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A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus. A new study has uncovered how this microbial combination manipulates sperm, which could lead to refined techniques to control populations of agricultural pests and insects that carry diseases like Zika and dengue to humans.

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All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.

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A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity.

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Neutron star mergers are a treasure trove for new physics signals, with implications for determining the true nature of dark matter, according to physicists.