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Categories: Biology: Developmental, Engineering: Robotics Research

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Researchers found that adding a newly developed modified sugar, BNAP-AEO, to gapmer antisense oligonucleotides (ASOs) increased their affinity for target RNAs, thus significantly enhancing their gene-silencing effects in vitro and in vivo. The BNAP-AEO modification also decreased gapmer ASO toxicity to the central nervous system (CNS), suggesting that it could improve the clinical application of ASO treatment of CNS disease.

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Researchers have used computational design methods to develop non-metal organic porous framework materials, with potential applications in areas such as catalysis, water capture or hydrogen storage.

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Researchers trained an AI model to accurately predict male fruit flies' courtship behavior in response to any sight of a female. This breakthrough offers new insight into how the brain processes visual data and may someday pave the way for artificial vision technology.

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Researchers describe cell-in-cell phenomena in which one cell engulfs and sometimes consumes another. The study shows that cases of this behavior, including cell cannibalism, are widespread across the tree of life. The findings challenge the common perception that cell-in-cell events are largely restricted to cancer cells. Rather, these events appear to be common across diverse organisms, from single-celled amoebas to complex multicellular animals.

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See how an autonomous robot created a shock-absorbing shape no human ever could -- and what it means for designing safer helmets, packaging, car bumpers, and more.

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Two new studies detail the changes seen at the single-cell level in pig organs and recipient human bodies before, during, and just after the xenotransplantation surgeries in the decedents.

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From the small ossicones on a giraffe to the gigantic antlers of a male moose -- which can grow as wide as a car -- the headgear of ruminant hooved mammals is extremely diverse, and new research suggests that despite the physical differences, fundamental aspects of these bony adaptations likely evolved from a common ancestor.

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Two newly discovered mechanisms in bacteria have been identified that can contribute to the development of antibiotic resistance. Changing the number of copies of resistance genes in bacteria increases antibiotic resistance, and can do so very quickly. These two mechanisms, along with a third known mechanism, can occur independently of each other, even within the same bacterial cell.

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Using more robots to close labor gaps in the hospitality industry may backfire and cause more human workers to quit, according to a new study. The study, involving more than 620 lodging and food service employees, found that 'robot-phobia' -- specifically the fear that robots and technology will take human jobs -- increased workers' job insecurity and stress, leading to greater intentions to leave their jobs. The impact was more pronounced with employees who had real experience working with robotic technology. It also affected managers in addition to frontline workers.

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A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD) from cervids -- deer, elk and moose -- to people. The findings are consistent with decades of similar research in animal models.

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Physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery.

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Plants have special corrective molecules at their disposal that can make retrospective modifications to copies of genes. However, it would appear that these 'Tipp-Ex proteins' do not have permission to work in all areas of the cell, only being used in chloroplasts and mitochondria. A study has now explained why this is the case. It suggests that the correction mechanism would otherwise modify copies that have nothing wrong with them, with fatal consequences for the cell.

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If fruit fly wings do not develop into the right shape, the flies will die. Researchers have learned how fly embryo cells develop as they need to, opening a window into human development and possible treatments for birth defects.

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A molecular biologist may have found a new 'rule of biology.' The rule challenges long-held notions that most living organisms prefer stability over instability because stability requires less energy and fewer resources.

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What features does a robotic guide dog need? Ask the blind, say researchers. A new study identifies how to develop robot guide dogs with insights from guide dog users and trainers.

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Scientists have discovered that colonies of gelatinous sea animals swim through the ocean in giant corkscrew shapes using coordinated jet propulsion, an unusual kind of locomotion that could inspire new designs for efficient underwater vehicles.

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SuperLimbs, a system of wearable robotic limbs, can physically support an astronaut and lift them back on their feet after a fall, helping them conserve energy for other essential tasks.

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A team of researchers has developed a drone that flies autonomously using neuromorphic image processing and control based on the workings of animal brains. Animal brains use less data and energy compared to current deep neural networks running on GPUs (graphic chips). Neuromorphic processors are therefore very suitable for small drones because they don't need heavy and large hardware and batteries. The results are extraordinary: during flight the drone's deep neural network processes data up to 64 times faster and consumes three times less energy than when running on a GPU. Further developments of this technology may enable the leap for drones to become as small, agile, and smart as flying insects or birds.

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Research could pave the way for a prosthetic hand and robot to be able to feel touch like a human hand. The technology could also be used to help restore lost functionality to patients after a stroke.

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Researchers have leveraged deep learning techniques to enhance the image quality of a metalens camera. The new approach uses artificial intelligence to turn low-quality images into high-quality ones, which could make these cameras viable for a multitude of imaging tasks including intricate microscopy applications and mobile devices.