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Categories: Biology: Developmental, Physics: General

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Researchers invented a technique that allows them to observe which genes and enhancers are active in a cell at the same time. This could help them determine which enhancers control which genes and may reveal potential new drug targets for genetic disorders.

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A recent study provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can help develop preventive health measures for men wishing to become fathers: The healthier the father's diet, the lower the risk for their children to develop obesity or diseases such as diabetes later in life.

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Nanoscale electron transfer (ET) in solids is fundamental to the development of multifunctional materials. However, ET in solids is not yet clearly understood. Now, researchers achieved a direct observation of solid-state ET through X-ray crystal analysis by fabricating a novel double-walled non-covalent crystalline nanotube, which can absorb electron donor molecules and maintain its crystalline structure during ET. This innovative approach can lead to the design of novel functional materials soon.

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Researchers uncover how the halogen bond can be exploited to direct sequential dynamics in the multi-functional crystals, offering crucial insights for developing ultrafast-response times for multilevel optical storage.

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Polarized light waves spin clockwise or counterclockwise as they travel, with one direction behaving differently than the other as it interacts with molecules. This directionality, called chirality or handedness, could provide a way to identify and sort specific molecules for use in biomedicine applications, but researchers have had limited control over the direction of the waves -- until now.

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Biological processes depend on puzzle pieces coming together and interacting. Under specific conditions, these interactions can create something new without external input. This is called self-organization, as seen in a school of fish or a flock of birds. Interestingly, the mammalian embryo develops similarly. Scientists now introduce a mathematical framework that analyzes self-organization from a single cell to a multicellular organism.

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A team of researchers has created a new way to visualize crystals by peering inside their structures, akin to having X-ray vision. Their new technique -- which they aptly named 'Crystal Clear' -- combines the use of transparent particles and microscopes with lasers that allow scientists to see each unit that makes up the crystal and to create dynamic three-dimensional models.

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An international research team has sparked interest in the scientific community with results in quantum physics. In their current study, the researchers reinterpret the Higgs mechanism, which gives elementary particles mass and triggers phase transitions, using the concept of 'magnetic quivers.'

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The intermediate range order of covalent glasses has been extensively studied in terms of the first sharp diffraction peak (FSDP), but the direct observation of the atomic density fluctuations that give rise to FSDP is still lacking. Addressing this gap, researchers employed a new energy-filtered angstrom-beam electron diffraction technique to provide the direct experimental observation for the origin of FSDP in silica glass, providing important insights into the atomic structure of glasses.

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Physicists describe the successful creation of a molecular Bose-Einstein condensate (BEC). Made up of dipolar sodium-cesium molecules that were cooled with the help of microwave shielding to just 5 nanoKelvin and lasted for up to two seconds, the new molecular BEC will help scientists explore a number of different quantum phenomena, including new types of superfluidity, and enable the creation of quantum simulators to ecreate the enigmatic properties of complex materials, like solid crystals.

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A technical achievement marks a significant advance in the burgeoning field of observing individual molecules without the aid of fluorescent labels. While these labels are useful in many applications, they alter molecules in ways that can obscure how they naturally interact with one another. The new label-free method makes the molecules so easy to detect, it is almost as if they had labels.

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Researchers combined computer simulations and transmission electron microscopy experiments to better understand the ordering mobility and formation of microstructure domains in Fe3Al alloy. They were able to correlate structural changes with heat treatment to understand how particular mechanical behavior can be achieved. This is expected to allow the superelastic properties of Fe3Al to harnessed for the 3D printing of construction materials for absorbing seismic activity.

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Lenses are used to bend and focus light. Normal lenses rely on their curved shape to achieve this effect, but physicists have made a flat lens of only three atoms thick which relies on quantum effects. This type of lens could be used in future augmented reality glasses.

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Researchers demonstrated a quantum algorithmic speedup with the quantum approximate optimization algorithm, laying the groundwork for advancements in telecommunications, financial modeling, materials science and more.

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Engineers establish the link between oxygen and graphene quality and present an oxygen-free chemical vapor deposition method (OF-CVD) that can reproducibly create high-quality samples for large-scale production. The graphene they synthesized with their new method proved nearly identical to exfoliated samples and was capable of producing the fractional quantum Hall effect.

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The benefits gained with higher lifestyle scores may be associated with the positive influence of heart disease risk factors on the aging of the body and its cells, finds a new study in the Journal of the American Heart Association

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Researchers have managed to generate propagating spin waves at the nanoscale and discovered a novel pathway to modulate and amplify them. Their discovery could pave the way for the development of dissipation free quantum information technologies. As the spin waves do not involve electric currents these chips will be free from associated losses of energy. The rapidly growing popularity of artificial intelligence comes with an increasing desire for fast and energy efficient computing devices and calls for novel ways to store and process information. The electric currents in conventional devices suffer from losses of energy and subsequent heating of the environment.

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A new deep learning model performs a task that biologists have struggled with for centuries -- how to measure the incredibly complex process of embryonic development. Scientists have shown that the AI model, known as Dev-ResNet, can identify what happens and when during embryonic development, from video. While used in pond snail embryos for this study, in future the technique could be used to help accelerate understanding on how climate change, and other external factors, affect humans and animals in the earliest stages of life.

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Researchers have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.

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Researchers found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations without causing any apparent disease or abnormality. Even so-called normal cells carry all sorts of genetic mutations, meaning there are more genetic differences between individual cells in our bodies than between different human beings. The discovery was enabled by a single-cell sequencing technology called Strand-seq, a unique DNA sequencing technique that can reveal subtle details of genomes in single cells that are too difficult to detect with other methods.