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Categories: Biology: Developmental, Mathematics: Puzzles
Published Team creates novel rabies viral vectors for neural circuit mapping
(via sciencedaily.com) Original source A research team has created 20 new recombinant rabies viral vectors for neural circuit mapping that offer a range of significant advantages over existing tools, including the ability to detect microstructural changes in models of aging and Alzheimer's disease brain neurons.
Published Key genes linked to DNA damage and human disease uncovered
(via sciencedaily.com) Original source Scientists unveil 145 genes vital for genome health, and possible strategies to curb progression of human genomic disorders.
Published Pesticides to help protect seeds can adversely affect earthworms' health
(via sciencedaily.com) Original source While pesticides protect crops from hungry animals, pesky insects, or even microbial infections, they also impact other vital organisms, including bees and earthworms. And today, research reveals that worms are affected by the relatively small amounts of chemicals that can leach out of pesticide-treated seeds. Exposure to nonlethal amounts of these insecticides and fungicides resulted in poor weight gain and mitochondrial DNA (mtDNA) damage in the worms.
Published Why do flies fall in love? Researchers tease out the signals behind fruit fly courtship songs
(via sciencedaily.com) Original source Researchers have pinpointed the group of neurons in the nerve cord -- a structure analogous to our spinal cord -- that produce and pattern the fly's two major courtship songs. They've also measured neuronal activity in these cells while flies were singing to understand how these neurons control each type of song.
Published Nutrients direct intestinal stem cell function and affect aging
(via sciencedaily.com) Original source The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon aging. Researchers have discovered a new mechanism of action between the nutrient adaptation of intestinal stem cells and aging. The finding may make a difference when seeking ways to maintain the functional capacity of the aging gut.
Published New research uncovers biological drivers of heart disease risk
(via sciencedaily.com) Original source Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relationship between known CAD variants and the biological pathways they impact.
Published Researchers discover key to molecular mystery of how plants respond to changing conditions
(via sciencedaily.com) Original source A team of researchers recently published a pioneering study that answers a central question in biology: how do organisms rally a wide range of cellular processes when they encounter a change -- either internally or in the external environment -- to thrive in good times or survive the bad times? The research, focused on plants, identifies the interactions between four compounds: pectin, receptor proteins FERONIA and LLG1 and the signal RALF peptide.
Published Scientists develop new biocontainment method for industrial organisms
(via sciencedaily.com) Original source Researchers have developed a new biocontainment method for limiting the escape of genetically engineered organisms used in industrial processes.
Published Extra fingers and hearts: Pinpointing changes to our genetic instructions that disrupt development
(via sciencedaily.com) Original source Scientists can now predict which single-letter changes to the DNA within our genomes will alter genetic instructions and disrupt development, leading to changes such as the growth of extra digits and hearts. Such knowledge opens the door to predictions of which enhancer variants underlie disease in order to harness the full potential of our genomes for better human health.
Published Computer-engineered DNA to study cell identities
(via sciencedaily.com) Original source A new computer program allows scientists to design synthetic DNA segments that indicate, in real time, the state of cells. It will be used to screen for anti-cancer or viral infections drugs, or to improve gene and cell-based immunotherapies.
Published Mechanism discovered that protects tissue after faulty gene expression
(via sciencedaily.com) Original source A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.
Published The arrangement of bacteria in biofilms affects their sensitivity to antibiotics
(via sciencedaily.com) Original source Many bacteria form an antibiotic-resistant slime. Research detailing that slime's structure could help lead to new treatments.
Published LSH genes associated with defining the shapes of stems, flowers and leaves required for N-fixing root nodules
(via sciencedaily.com) Original source The developmental regulators that confer the identity of N-fixing root nodules belong to a transcription factor family (LSH) more commonly associated with defining the shapes of stems, flowers and leaves.
Published Swarming cicadas, stock traders, and the wisdom of the crowd
(via sciencedaily.com) Original source The springtime emergence of vast swarms of cicadas can be explained by a mathematical model of collective decision-making with similarities to models describing stock market crashes.
Published Using computers to design proteins allows researchers to make tunable hydrogels that can form both inside and outside of cells
(via sciencedaily.com) Original source New research demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.
Published DNA particles that mimic viruses hold promise as vaccines
(via sciencedaily.com) Original source Using a DNA-based delivery particle, researchers created a vaccine that can induce a strong antibody response against SARS-CoV-2.
Published 'Genomic time machine' reveals secrets of our DNA
(via sciencedaily.com) Original source Researchers reveal a novel method to uncover bits of our genetic blueprint that come from ancient genetic parasites, offering fresh insights into human evolution and health.
Published How macrophages regulate regenerative healing in spiny mice
(via sciencedaily.com) Original source A team of researchers is delving deeper into the science behind how spiny mice can regenerate lost tissue and using what they learn to trigger regeneration in other types of mice -- advances which one day may be translated into humans. Whereas adult laboratory mice heal injuries with scar tissue, spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body.
Published Cellular scaffolding rewired to make microscopic railways
(via sciencedaily.com) Original source Researchers were able to control the growth of thin, branching networks that support cellular structure and help cells function. The networks, called microtubules, can exert force and precisely transport chemicals at a subcellular level.
Published Researchers pinpoint most likely source of HIV rebound infection
(via sciencedaily.com) Original source Antiretroviral therapy (ART) does an excellent job at suppressing HIV to undetectable levels in the blood. However, small amounts of latent virus hide throughout the body, and when treatment is stopped, it opens the door for the virus to rebound. Researchers identified which tissues SIV, the nonhuman primate version of HIV, reemerges from first, just seven days after ART is stopped.