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Categories: Biology: Developmental, Mathematics: General
Published Mechanism discovered that protects tissue after faulty gene expression



A study has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.
Published The arrangement of bacteria in biofilms affects their sensitivity to antibiotics



Many bacteria form an antibiotic-resistant slime. Research detailing that slime's structure could help lead to new treatments.
Published LSH genes associated with defining the shapes of stems, flowers and leaves required for N-fixing root nodules



The developmental regulators that confer the identity of N-fixing root nodules belong to a transcription factor family (LSH) more commonly associated with defining the shapes of stems, flowers and leaves.
Published Swarming cicadas, stock traders, and the wisdom of the crowd



The springtime emergence of vast swarms of cicadas can be explained by a mathematical model of collective decision-making with similarities to models describing stock market crashes.
Published Using computers to design proteins allows researchers to make tunable hydrogels that can form both inside and outside of cells



New research demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.
Published DNA particles that mimic viruses hold promise as vaccines



Using a DNA-based delivery particle, researchers created a vaccine that can induce a strong antibody response against SARS-CoV-2.
Published 'Genomic time machine' reveals secrets of our DNA



Researchers reveal a novel method to uncover bits of our genetic blueprint that come from ancient genetic parasites, offering fresh insights into human evolution and health.
Published How does a 'reverse sprinkler' work? Researchers solve decades-old physics puzzle



For decades scientists have been trying to solve Feynman's Sprinkler Problem: How does a sprinkler running in reverse work? Through a series of experiments, a team of mathematicians has figured out how flowing fluids exert forces and move structures, thereby revealing the answer to this long-standing mystery.
Published How macrophages regulate regenerative healing in spiny mice



A team of researchers is delving deeper into the science behind how spiny mice can regenerate lost tissue and using what they learn to trigger regeneration in other types of mice -- advances which one day may be translated into humans. Whereas adult laboratory mice heal injuries with scar tissue, spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body.
Published Cellular scaffolding rewired to make microscopic railways



Researchers were able to control the growth of thin, branching networks that support cellular structure and help cells function. The networks, called microtubules, can exert force and precisely transport chemicals at a subcellular level.
Published New method flips the script on topological physics



The branch of mathematics known as topology has become a cornerstone of modern physics thanks to the remarkable -- and above all reliable -- properties it can impart to a material or system. Unfortunately, identifying topological systems, or even designing new ones, is generally a tedious process that requires exactly matching the physical system to a mathematical model. Researchers have demonstrated a model-free method for identifying topology, enabling the discovery of new topological materials using a purely experimental approach.
Published Researchers pinpoint most likely source of HIV rebound infection



Antiretroviral therapy (ART) does an excellent job at suppressing HIV to undetectable levels in the blood. However, small amounts of latent virus hide throughout the body, and when treatment is stopped, it opens the door for the virus to rebound. Researchers identified which tissues SIV, the nonhuman primate version of HIV, reemerges from first, just seven days after ART is stopped.
Published World's first successful embryo transfer in rhinos paves the way for saving the northern white rhinos from extinction



Scientists have succeeded in achieving the world's first pregnancy of a rhinoceros after an embryo transfer. The southern white rhino embryo was produced in vitro from collected egg cells and sperm and transferred into a southern white rhino surrogate mother at the Ol Pejeta Conservancy in Kenya on September 24, 2023. The BioRescue team confirmed a pregnancy of 70 days with a well-developed 6.4 cm long male embryo. The successful embryo transfer and pregnancy are a proof of concept and allow to now safely move to the transfer of northern white rhino embryos -- a cornerstone in the mission to save the northern white rhino from extinction.
Published What coffee with cream can teach us about quantum physics



A new advancement in theoretical physics could, one day, help engineers develop new kinds of computer chips that might store information for longer in very small objects.
Published New tool reveals gene behavior in bacteria



Researchers showed that the way in which genes are turned on and off as bacteria grow provide clues to their regulation.
Published DNA construction led to unexpected discovery of important cell function



Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for understanding how the Notch signalling pathway works and how it is involved in several serious diseases.
Published Study throws our understanding of gene regulation for a loop



To function properly, the genetic material is highly organized into loop structures that often bring together widely separated sections of the genome critical to the regulation of gene activity. Scientists now address how these loops can help repress or silence gene activity, with potentially far-reaching effects on human health.
Published Machine learning reveals sources of heterogeneity among cells in our bodies



A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of chemotherapy treatments, or set a new paradigm in the study of antibiotic-resistant bacteria.
Published Surprisingly simple model explains how brain cells organize and connect



A new study by physicists and neuroscientists describes how connectivity among neurons comes about through general principles of networking and self-organization, rather than the biological features of an individual organism.
Published Bioinformatics: Researchers develop a new machine learning approach



To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.