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Categories: Biology: Developmental, Mathematics: General

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'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism.

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Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways. A new review highlights six mechanisms by which cells repair DNA damage. By attacking these mechanisms, future applied researchers will be able to trip up cancer's reproduction and growth.

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A researcher has solved a nearly 60-year-old game theory dilemma called the wall pursuit game, with implications for better reasoning about autonomous systems such as driver-less vehicles.

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A new study explores exactly what leads to the generation of Th17 cells -- an important subtype of cells in the intestine -- and uncovers some of the underappreciated molecular players and events that lead to cell differentiation in the gut.

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With the aid of some sea slugs, chemists have discovered that one of the smallest conceivable tweaks to a biomolecule can elicit one of the grandest conceivable consequences: directing the activation of neurons. The team has shown that the orientation of a single amino acid -- in this case, one of dozens found in the neuropeptide of a sea slug -- can dictate the likelihood that the peptide activates one neuron receptor versus another. Because different types of receptors are responsible for different neuronal activities, the finding points to another means by which a brain or nervous system can regulate the labyrinthine, life-sustaining communication among its cells.

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Meiotic recombination assures genetic variation during breeding. During meiotic prophase I, chromosomes are organized in a loop-base array by a proteinaceous structure called meiotic chromosome axis which is critical for meiotic recombination and genetically diverse gametes. An international research team reports the application of a TurboID (TbID)-based approach to identify proteins in proximity of meiotic chromosome axes in Arabidopsis thaliana. Not only known but also new meiotic proteins were uncovered.

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A whole new world of antibiotics is waiting inside the viruses that infect bacteria. Scientists are making it easier to study them.

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The skeleton, tendons, and glands of a functional jaw all derive from the same population of stem cells, which arise from a cell population known as neural crest. To discover how these neural crest-derived cells know to make the right type of cell in the right location, researchers focused on a particular gene, Nr5a2, that was active in a region of the face that makes tendons and glands, but not skeleton. To understand the role of Nr5a2, the scientists created zebrafish lacking this gene. These mutant zebrafish generated excess cartilage and were missing tendons in their jaws.

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Researchers have created a radical new view of how immune cells recognise threats such as viruses. The discovery could be used to design better vaccines and to gain a deeper insight into autoimmune diseases and allergies.

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Most cells in the bodies of living things duplicate their contents and physically separate into new cells through the process of cell division. But across many species, germ cells, those that become eggs or sperm, don't fully separate. They remain interconnected through small bridges called ring canals and cluster together. In a new study, researchers uncover how it is that germ cells in fruit flies form these ring canals, a finding that they say will provide new insights into a widely shared feature of development and into diseases in which cell division is disrupted.

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Germination is a crucial stage in the life of a plant as it will leave the stage of seed resistant to various environmental constraints (climatic conditions, absence of nutritive elements, etc.) to become a seedling much more vulnerable. The survival of the young plant depends on the timing of this transition. It is therefore essential that this stage be finely controlled. Botanists have now discovered the internal thermometer of seeds that can delay or even block germination if temperatures are too high for the future seedling. This work could help optimize plant growth in a context of global warming.

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New methodology and tools provide an opportunity to watch in unprecedented detail as a phage attacks a bacterium.

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Obese fruit flies are the experimental subjects in a study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels.

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Mathematical research brings new understanding of crowd formation and behavior.

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The findings offer a new way to understand how some ants become total layabouts.

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A new study finds that high school students identify more with math if they see their math teacher treating everyone in the class equitably, especially in racially diverse schools. While the relationship between teacher equity and math identity was evident across races, there was an interesting exception. Black students, in general, had strong math identities, regardless of their teacher's actions.  Learning about the factors that affect student math identity is important because a student's attitude towards the subject influences the courses that they take as well as their future career selections. This study suggests that teachers may have a larger role to play in helping students develop a positive math identity than previously recognized.

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An international team of bee researchers has integrated a calcium sensor into honey bees to enable the study of neural information processing including response to odors. This also provides insights into how social behavior is located in the brain.

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Scientists recently developed an efficient way to transplant pancreatic islets and demonstrated that the method can effectively reverse type 1 diabetes in nonhuman primates.

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Researchers have discovered a strong immunological effect of the molecule LecB -- and a way to prevent it.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.