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Categories: Biology: Developmental, Mathematics: Statistics
Published How a natural compound from sea squirts combats cancer
(via sciencedaily.com) Original source Trabectedin, a promising drug derived from the sea squirt Ecteinascidia turbinata, has shown potential in combating cancers resistant to conventional treatments. However, its precise mechanism of action has remained elusive -- until now.
Published How do neural networks learn? A mathematical formula explains how they detect relevant patterns
(via sciencedaily.com) Original source Neural networks have been powering breakthroughs in artificial intelligence, including the large language models that are now being used in a wide range of applications, from finance, to human resources to healthcare. But these networks remain a black box whose inner workings engineers and scientists struggle to understand. Now, a team has given neural networks the equivalent of an X-ray to uncover how they actually learn.
Published Researchers uncover protein responsible for cold sensation
(via sciencedaily.com) Original source Researchers have identified the protein that enables mammals to sense cold, filling a long-standing knowledge gap in the field of sensory biology.
Published Research sheds light on new strategy to treat infertility
(via sciencedaily.com) Original source New research describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos. The technique could be used by women of advanced maternal age or for those who are unable to produce viable eggs due to previous treatment for cancer or other causes. It also raises the possibility of men in same-sex relationships having children who are genetically related to both parents.
Published New study discovers how altered protein folding drives multicellular evolution
(via sciencedaily.com) Original source Researchers have discovered a mechanism steering the evolution of multicellular life. They identified how altered protein folding drives multicellular evolution.
Published Mutation solves a century-old mystery in meiosis
(via sciencedaily.com) Original source A team deciphers complicated mechanism underlying genetic diversity.
Published Researchers develop artificial building blocks of life
(via sciencedaily.com) Original source For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.
Published Vitamin A may play a central role in stem cell biology and wound repair
(via sciencedaily.com) Original source Retinoic acid, the active state of Vitamin A, appears to regulate how stem cells enter and exit a transient state central to their role in wound repair.
Published How does a virus hijack insect sperm to control disease vectors and pests?
(via sciencedaily.com) Original source A widespread bacteria called Wolbachia and a virus that it carries can cause sterility in male insects by hijacking their sperm, preventing them from fertilizing eggs of females that do not have the same combination of bacteria and virus. A new study has uncovered how this microbial combination manipulates sperm, which could lead to refined techniques to control populations of agricultural pests and insects that carry diseases like Zika and dengue to humans.
Published The Malaria parasite generates genetic diversity using an evolutionary 'copy-paste' tactic
(via sciencedaily.com) Original source All modern Plasmodium falciparum, the deadliest malaria parasite in humans, are descendants of one initial infection and so are very closely related, with relatively limited genetic differences. A long-standing mystery in the field has revolved around a very few locations in the P. falciparum genome where there are 'spikes' of mutations -- far more than anywhere else. Researchers have identified two genes in which these unusual mutation spikes result from DNA being copied and pasted from one gene to another.
Published Cracking epigenetic inheritance: Biologists discovered the secrets of how gene traits are passed on
(via sciencedaily.com) Original source A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division. Understanding how this coupled mechanism could lead to new treatments for cancer and other epigenetic diseases by targeting specific changes in gene activity.
Published Universal tool for tracking cell-to-cell interactions
(via sciencedaily.com) Original source An updated method for directly observing physical interactions between cells, could allow scientists to one day map every possible cell interaction.
Published Synthetic gene helps explain the mysteries of transcription across species
(via sciencedaily.com) Original source 'Random DNA' is naturally active in the one-celled fungi yeast, while such DNA is turned off as its natural state in mammalian cells, despite their having a common ancestor a billion years ago and the same basic molecular machinery, a new study finds.
Published Decoding the language of epigenetic modifications
(via sciencedaily.com) Original source Epigenetic changes play important roles in cancer, metabolic and aging-related diseases, but also during loss of resilience as they cause the genetic material to be incorrectly interpreted in affected cells. A major study now provides important new insights into how complex epigenetic modification signatures regulate the genome. This study will pave the way for new treatments of diseases caused by faulty epigenetic machineries.
Published Lab-grown liver organoid to speed up turtle research, making useful traits easier to harness
(via sciencedaily.com) Original source Researchers developed protocols for growing organoids that mimic a turtle liver, the first organoids developed for a turtle and only the second for any reptile. The discovery will aid deeper study of turtle genetics, including the cause of traits with potential medical applications for humans such as the ability to survive weeks without oxygen.
Published Microalgae with unusual cell biology
(via sciencedaily.com) Original source A globally distributed single-celled organism that occurs in harmful algal blooms has been found to exhibit an unusual organisation of photosynthesis. Researchers have taken a closer look at the unusual cell biology of the species Prorocentrum cordatum from the group of dinoflagellates. The results of their study could help to better understand the role of the species in the environment and the increased occurrence of algal blooms at higher water temperatures.
Published Network of quantum sensors boosts precision
(via sciencedaily.com) Original source Quantum sensor technology promises even more precise measurements of physical quantities. A team has now compared the signals of up to 91 quantum sensors with each other and thus successfully eliminated the noise caused by interactions with the environment. Correlation spectroscopy can be used to increase the precision of sensor networks.
Published Shining a light on the effects of habituation and neural adaptation on the evolution of animal signals
(via sciencedaily.com) Original source A new paper examines the possible effects of two properties of receiver playing fields documented in studies of animal psychology -- habituation and neural adaptation -- on the efficacy of mate choice signals.
Published Effect of keratin microsphere gel on hair growth in mice
(via sciencedaily.com) Original source Keratin microsphere gel, consisting of keratin-based microspheres that swell in water to form a gel, has shown efficacy in promoting hair follicle growth in murine models. Its potential application as an active ingredient in hair regrowth treatments with minimal side effects is anticipated.
Published The Golgi organelle's ribbon structure is not exclusive to vertebrates, contrary to previous consensus
(via sciencedaily.com) Original source Researchers report that the Golgi ribbon, an organelle structure previously thought to be exclusive to vertebrates, is also present in animal taxa, including mollusks, earthworms, and sea urchins. The function of the Golgi ribbon is still enigmatic, but its presence in diverse animal lineages indicates that its function is not vertebrate specific, as previously thought. The team also showed Golgi ribbons form at a specific timepoint during embryogenesis, which suggests that they might play a role in cell differentiation.