Showing 20 articles starting at article 341
< Previous 20 articles Next 20 articles >
Categories: Biology: Developmental, Mathematics: Statistics
Published Researchers studied thousands of fertility attempts hoping to improve IVF
(via sciencedaily.com) Original source By genetically testing nearly one thousand embryos, scientists have provided the most detailed analysis of embryo fate following human in vitro fertilization.
Published Did animal evolution begin with a predatory lifestyle?
(via sciencedaily.com) Original source Surprising findings on the development of sea anemones suggest that a predatory lifestyle molded their evolution and had a significant impact on the origin of their nervous system. The researchers were able to show that the young life stages (larvae) of the small sea anemone Aiptasia actively feed on living prey and are not dependent on algae. To capture its prey, the anemone larvae use specialized stinging cells and a simple neuronal network.
Published A lethal parasite's secret weapon: Infecting non-immune cells
(via sciencedaily.com) Original source The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.
Published Fish reveal cause of altered human facial development
(via sciencedaily.com) Original source Some substances in medicines, household items and the environment are known to affect prenatal child development. Researchers tested the effects of five drugs (including caffeine and the blood thinner warfarin) on the growth of zebrafish embryos. They found that all five had the same effect, impairing the migration of bone-forming cells which resulted in the onset of facial malformation. Zebrafish embryos grow quickly, are transparent and develop outside of the parent's body, making them ideal for studying early development. A zebrafish-based system could be used to easily screen for potentially harmful substances, reducing animal testing on mammals and supporting parents-to-be when making choices for themselves and their baby.
Published Vision in the brain: Hardwired for action
(via sciencedaily.com) Original source Brain circuits for vision develop without any kind of input from the retina in zebrafish.
Published New information on the most important early stage of embryonic development
(via sciencedaily.com) Original source A new discovery by researchers challenges our current understanding of gastrulation, the most important stage of early embryonic development.
Published Tiny CRISPR tool could help shred viruses
(via sciencedaily.com) Original source Scientists mapped out the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems then used that knowledge to modify its structure and improve its accuracy.
Published How the heart starts beating
(via sciencedaily.com) Original source Researchers discover that heart cells in developing zebrafish start beating suddenly and all at once
Published Researchers discover disease-causing stem cells in lungs of cystic fibrosis patients
(via sciencedaily.com) Original source Experts in cloning and stem cell science are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis, and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.
Published Jellyfish, with no central brain, shown to learn from past experience
(via sciencedaily.com) Original source Even without a central brain, jellyfish can learn from past experiences like humans, mice, and flies, scientists report for the first time. They trained Caribbean box jellyfish (Tripedalia cystophora) to learn to spot and dodge obstacles. The study challenges previous notions that advanced learning requires a centralized brain and sheds light on the evolutionary roots of learning and memory.
Published Researchers develop first method to study microRNA activity in single cells
(via sciencedaily.com) Researchers have developed the first method to uncover the tasks that microRNAs perform in single cells. This is a huge improvement over existing state-of-the-art methods that require millions of cells and will for the first time allow researchers to study microRNAs in complex tissues such as brains.
Published Scientists regenerate neurons that restore walking in mice after paralysis from spinal cord injury
(via sciencedaily.com) Original source In a new study in mice, researchers have uncovered a crucial component for restoring functional activity after spinal cord injury. The neuroscientists have shown that re-growing specific neurons back to their natural target regions led to recovery, while random regrowth was not effective.
Published Exercise and muscle regulation: Implications for diabetes and obesity
(via sciencedaily.com) Original source How do our muscles respond at the molecular level to exercise? Researchers have unraveled the cellular basis and signaling pathways responsible for the positive impact of physical activity on our overall health. Regulatory T cells, a type of immune cell, play a critical role in ensuring proper muscle function. These novel insights are paving the path towards precision medicines targeting metabolic disorders like obesity and diabetes, as well as muscle-related illnesses.
Published Genetically modifying individual cells in animals
(via sciencedaily.com) Original source Researchers have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.
Published Tiny sea creatures reveal the ancient origins of neurons
(via sciencedaily.com) Original source A new study sheds new light on the origins of modern brain cells. Researchers find evidence that specialized secretory cells found in placozoans, tiny sea creatures the size of a grain of sand, have many similarities to the neuron, such as the genes required to create a partial synapse. From an evolutionary point of view, early neurons might have started as something like these cells, eventually gaining the ability to create a complete synapse, form axons and dendrites and create ion channels that generate fast electrical signals -- innovations which gave rise to the neuron in more complex animals such as jellyfish. Though the complete story of how the first neuron appeared remains to be told, the study demonstrates that the basic building blocks for our brain cells were forming in the ancestors of placozoans grazing inconspicuously in the shallow seas of Earth around 800 million years ago.
Published Genome editing: Reducing off-target mutations in DNA
(via sciencedaily.com) Original source Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.
Published Genetically modified bacteria break down plastics in saltwater
(via sciencedaily.com) Original source Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.
Published Using topology, Researchers advance understanding of how cells organize themselves
(via sciencedaily.com) Original source R esearchers created a machine learning algorithm using computational topology that profiles shapes and spatial patterns in embryos to study how these cells organize themselves into tissue-like architectures. In a new study, they take that system to the next level, opening a path to studying how multiple types of cells assemble themselves.
Published Researchers discover tissue-specific protection against protein aggregation
(via sciencedaily.com) Original source Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.
Published Lack of maternal care affects development, microbiome and health of wild bees
(via sciencedaily.com) Original source Most wild bees are solitary, but one tiny species of carpenter bees fastidiously cares for and raises their offspring, an act that translates into huge benefits to the developing bee's microbiome, development and health, found researchers. Without maternal care the pathogen load of these developing bees ballooned -- 85 per cent of were fungi, while eight per cent were bacteria -- which can impact their microbiome, a critical component of bee health, as well as their development, immune system and gene expression.