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Categories: Biology: Developmental, Mathematics: Statistics

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Researchers have discovered a strong immunological effect of the molecule LecB -- and a way to prevent it.

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A major new study reveals a 'traffic light' mechanism controlling genetic activity within cells -- a system which could potentially be targeted by cancer drugs already in development. The research describes how 'epigenetic' changes to the structure of DNA can act as a stop-go signal in determining whether a gene should be read. Unlike our genetic make-up, which is well understood, the world of epigenetics is still largely unexplored and referred to as the 'dark matter' of the genome.

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A detailed atlas of gene expression in the zebrafish brain.

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Textbooks will tell you that in dividing cells, production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level. Molecular biologists have now discovered that this is not true: protein synthesis shows two peaks and lipid synthesis peaks once.

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Haematopoietic stem cell transplantation for the treatment of severe blood cancers is the only medical intervention that has cured two people living with HIV in the past. An international group of physicians and researchers has now identified another case in which HIV infection has been shown to be cured in the same way. The successful healing process of this third patient was for the first time characterized in great detail virologically and immunologically over a time span of ten years.

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A team has developed a new software tool to help researchers across the life sciences more efficiently analyze animal behaviors.

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When scientists disabled a single regulatory gene in a species of sea anemone, a stinging cell that shoots a venomous miniature harpoon for hunting and self-defense shifted to shoot a sticky thread that entangles prey instead, according to a new study.

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Researchers have created and preliminarily tested what they believe may be one of the first models for predicting who has the highest probability of being resistant to COVID-19 in spite of exposure to SARS-CoV-2, the virus that causes it.

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Scientists transform blood cells to regain a flexible fate, growing into a precursor of sperm cells.

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Researchers have generated the first induced pluripotent stem cells (iPSCs) from bats, gaining valuable insights into the close relationship between bats and viruses.

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Researchers made the stunning discovery that telomeres contain genetic information to produce two small proteins, one of which they found is elevated in some human cancer cells, as well as cells from patients suffering from telomere-related defects.

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Using artificial intelligence (AI), researchers can now follow cell movement across time and space. The method could be very helpful for developing more effective cancer medications.

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The behavioral disorders observed in autism are associated with a multitude of genetic alterations. Scientists have now found another molecular cause for this condition. The transcription factor MYT1L normally protects the molecular identity of nerve cells. If it is genetically switched off in human nerve cells or in mice, the functional changes and symptoms typical of autism occur. A drug that blocks sodium channels in the cell membrane can reverse the consequences of MYT1L failure and alleviate the functional and behavioral abnormalities in mice.

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Scientists have created a new technology to assemble matter in 3D. Their concept uses multiple acoustic holograms to generate pressure fields with which solid particles, gel beads and even biological cells can be printed. These results pave the way for novel 3D cell culture techniques with applications in biomedical engineering.

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Bee researchers have identified a new gene in honeybees, which is responsible for the dimorphic eye differentiation between males and females of the species. The researchers have now presented this gene and the evolutionary genetic conclusions they have drawn from it.

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In a new study, researchers discovered an unknown mechanism of how cells 'remember' their identity when they divide -- the cells' so-called epigenetic memory.

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Computer software can predict what happens to complex gene networks when individual genes are missing or dialed up more than usual. Mapping the roles of single genes in these networks is key to understanding healthy development and finding ways to regrow damaged cells and tissues. Understanding genetic errors could provide insight into birth defects, miscarriage or even cancer.

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Researchers show that brain organoids -- clumps of lab-grown neurons -- can integrate with rat brains and respond to visual stimulation like flashing lights.

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Researchers tested a large sample of the major AI technologies available today and found that not only did they reproduce human biases in facial age recognition, but they exaggerated those biases.

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A new biomaterial that can be injected intravenously, reduces inflammation in tissue and promotes cell and tissue repair. The biomaterial was tested and proven effective in treating tissue damage caused by heart attacks in both rodent and large animal models. Researchers also provided proof of concept in a rodent model that the biomaterial could be beneficial to patients with traumatic brain injury and pulmonary arterial hypertension.