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Categories: Biology: Developmental, Ecology: Research

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Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours -- sometimes more than a day -- in a reversible intermediate state, according to a new discovery. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

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Researchers have discovered that in thale cresses histone H3 lysine-9 (H3K9) methylation, conventionally thought to be a mark of turning off gene transcription, can also turn on gene expression via the interactions of two other proteins and histone marks. The molecular mechanisms demonstrate that rather than functioning as a simple 'off switch,' H3K9 methylation is more like a 'dimmer switch' that fine-tunes DNA transcription. The discovery suggests there might be similar mechanisms in other organisms, too.

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Researchers have projected future marine heatwaves will cause coral reefs to be at severe risk of bleaching for longer periods than previously seen.

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Study reveals how drug molecules bind in channels between neighboring cells, changing intercellular communication.

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A new article encourages researchers to focus their attention on mixoplankton, providing a set of methodologies to help expand our understanding of this critically important component of the marine ecosystem.

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New biologist-designed shelters will help endangered frogs survive the devastating impacts of a deadly fungal disease by regulating their body temperature to fight off infections.

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New research describes how nerve cells and muscle cells communicate through electrical signals during development -- a phenomenon known as bioelectricity. The communication, which takes place via specialized channels between cells, is vital for proper development and behavior. The study identifies specific genes that control the process, and pins down what happens when it goes wrong. The finding offers clues to the genetic origins of muscle disorders in humans.

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The study reveals vast differences in gene activity within the mitochondria of males compared to females. This is the first study to test effects of all 37 genes in the mitochondrial genome -- genes that copepods and humans share. The study found that males demonstrate more activity across all protein-coding mitochondrial genes than females. Although the study looks at tiny marine organisms called copepods, the findings have weighty implications for human medicine.

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There is a common belief that prescribed burning, thinning trees, and clearing underbrush reduce risks of the severity of future fires. But is that true? A new project analyzing 40 studies where wildfire burned into different vegetation treatments, spanning 11 western states. Researchers found overwhelming evidence that in seasonally dry mixed conifer forests in the western U.S., reducing surface and ladder fuels and tree density through thinning, coupled with prescribed burning or pile burning, could reduce future wildfire severity by more than 60% relative to untreated areas.

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The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.

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Protected areas, like nature reserves, can conserve biodiversity without harming local economic growth, countering a common belief that conservation restricts development. A new study outlines what is needed for conservation to benefit both nature and people.

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Researchers have discovered a new fundamental mechanism governing the rules of ageing in worms. The researchers were able to manipulate the mechanism through genetic interventions which dramatically extend not just the lifespan of the worms, but also their health-span. In other words, trading weak, frail old age with vigorous golden years -- all without altering their diet, environment or other external factors.

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An international team of scientists has recently found that non-native species are expanding their ranges many orders of magnitude faster than native ones, in large part due to inadvertent human help. Even seemingly sedentary non-native plants are moving at three times the speed of their native counterparts in a race where, because of the rapid pace of climate change and its effect on habitat, speed matters. To survive, plants and animals need to be shifting their ranges by 3.25 kilometers per year just to keep up with the increasing temperatures and associated climactic shifts -- a speed that native species cannot manage without human help.

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Natural hazards can speed up the extinction process of land animals that have limited distribution and/or small populations. But there is hope to turn the negative development around, says researchers behind new study.

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Formation of the body axes is a critical part of embryonic development. They guarantee that all body parts end up where they belong and that no ears grow on our backs. The head-tail axis, for example, determines the orientation of the two ends of the body. It was previously assumed that this axis is largely determined by the interplay between the Nodal and BMP signals. However, there appears to be another player in this system, as researchers have now discovered by using an embryo-like model system they developed. In the absence of BMP, the signalling molecule beta-catenin takes on the role of the Nodal antagonist. This new mechanism could be a flexible solution for axis formation in embryos with different shapes.

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Using genome reconstruction, scientists unveiled a once 'invisible' fish parasite present in many marine fish world-wide that belongs to the apicomplexans, one of the most important groups of parasites at a clinical level. However, it had gone unnoticed in previous studies. The parasite is geographically and taxonomically widespread in fish species around the planet, with implications for commercial fishing and oceanic food webs.

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In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.

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New research has found that sharks retained high levels of functional diversity for most of the last 66 million years, before steadily declining over the last 10 million years to its lowest value in the present day.

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The increase in the frequency and intensity of marine heatwaves in recent decades is one of the effects of global climate change. A study shows that the extreme heatwave of 2022 caused an 'unprecedented' increase in mortality of the red gorgonian Paramuricea clavata, affecting 70% of the colonies located in the Montgr Natural Park, the Medes Islands and the Baix Ter. According to the researchers, these results are 'alarming and threaten the viability' of this species of great value for the biodiversity of benthic ecosystems, since it is considered to be an inhabitant-forming species.

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Gray whales that spend their summers feeding in the shallow waters off the Pacific Northwest coast have undergone a significant decline in body length since around the year 2000, a new study found.