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Categories: Biology: Developmental, Ecology: Extinction
Published Researchers develop first method to study microRNA activity in single cells
(via sciencedaily.com) Researchers have developed the first method to uncover the tasks that microRNAs perform in single cells. This is a huge improvement over existing state-of-the-art methods that require millions of cells and will for the first time allow researchers to study microRNAs in complex tissues such as brains.
Published Scientists regenerate neurons that restore walking in mice after paralysis from spinal cord injury
(via sciencedaily.com) Original source In a new study in mice, researchers have uncovered a crucial component for restoring functional activity after spinal cord injury. The neuroscientists have shown that re-growing specific neurons back to their natural target regions led to recovery, while random regrowth was not effective.
Published Understanding the sex life of coral gives hope of clawing it back from the path to extinction
(via sciencedaily.com) Original source Scientists have mapped the reproductive strategies and life cycle of an endangered coral species, the purple cauliflower soft coral Dendronephthya australis. Lab-grown larvae have been successfully introduced back into the wild.
Published Exercise and muscle regulation: Implications for diabetes and obesity
(via sciencedaily.com) Original source How do our muscles respond at the molecular level to exercise? Researchers have unraveled the cellular basis and signaling pathways responsible for the positive impact of physical activity on our overall health. Regulatory T cells, a type of immune cell, play a critical role in ensuring proper muscle function. These novel insights are paving the path towards precision medicines targeting metabolic disorders like obesity and diabetes, as well as muscle-related illnesses.
Published Genetically modifying individual cells in animals
(via sciencedaily.com) Original source Researchers have developed a method that lets them genetically modify each cell differently in animals. This allows them to study in a single experiment what used to require many animal experiments. Using the new method, the researchers have discovered genes that are relevant for a severe rare genetic disorder.
Published Slow growth in crocodile ancestors pre-dated their semi-aquatic lifestyle
(via sciencedaily.com) Original source A groundbreaking study is reshaping our understanding of crocodile evolution by pinpointing the onset of slow growth rates to the Late Triassic period, much earlier than the previously assumed Early Jurassic timeline. The research highlights newly discovered fossil crocodile ancestors (known as crocodylomorphs) that exhibited slow growth rates, similar to modern-day crocodilians. Intriguingly, these early crocodylomorphs were not the lethargic, semi-aquatic creatures we are familiar with today; they were small, active, and fully terrestrial. The study also suggests that this slow-growth strategy was not a mere evolutionary quirk but a survival mechanism, as only the slow-growing crocodylomorphs managed to survive the End-Triassic mass extinction. This stands in stark contrast to the fast-growing dinosaurs of the same era, setting the stage for the divergent evolutionary paths that would later define their modern descendants.
Published Researchers issue urgent call to save the world's largest flower -Rafflesia -- from extinction
(via sciencedaily.com) Original source A new study finds that most Rafflesia species, which produce the world's largest flowers, face extinction. Lack of protection at local, national, and international levels means that remaining populations are under critical threat.
Published Researchers discover a new species of larger benthic foraminifer from the Ryukyu Islands
(via sciencedaily.com) Original source An international group of researchers have discovered a previously unknown species of large foraminifer, shedding new light on the ecological evolution and biodiversity of coral reefs in the Ryukyu Islands.
Published Tiny sea creatures reveal the ancient origins of neurons
(via sciencedaily.com) Original source A new study sheds new light on the origins of modern brain cells. Researchers find evidence that specialized secretory cells found in placozoans, tiny sea creatures the size of a grain of sand, have many similarities to the neuron, such as the genes required to create a partial synapse. From an evolutionary point of view, early neurons might have started as something like these cells, eventually gaining the ability to create a complete synapse, form axons and dendrites and create ion channels that generate fast electrical signals -- innovations which gave rise to the neuron in more complex animals such as jellyfish. Though the complete story of how the first neuron appeared remains to be told, the study demonstrates that the basic building blocks for our brain cells were forming in the ancestors of placozoans grazing inconspicuously in the shallow seas of Earth around 800 million years ago.
Published RNA for the first time recovered from an extinct species
(via sciencedaily.com) Original source A new study shows the isolation and sequencing of more than a century-old RNA molecules from a Tasmanian tiger specimen preserved at room temperature in a museum collection. This resulted in the reconstruction of skin and skeletal muscle transcriptomes from an extinct species for the first time. The researchers note that their findings have relevant implications for international efforts to resurrect extinct species, including both the Tasmanian tiger and the woolly mammoth, as well as for studying pandemic RNA viruses.
Published The pace of climate-driven extinction is accelerating
(via sciencedaily.com) Original source Studying a lizard species in Arizona mountains, researchers found 70 years' worth of climate-related extinction occurred in only seven years.
Published Almost half of koala habitats will be under high bushfire threat by 2070
(via sciencedaily.com) The research team generated a series of fire susceptibility maps. These show the proportion of Australia experiencing 'high' or 'very high' fire susceptibility increasing from 14.9% now to 15.66% by 2070 -- while fire susceptibility of areas suitable for the plants that koalas depend on is tipped to jump from 39.56% to 44.61% by 2070.
Published Study shows replanting logged forests with diverse mixtures of seedlings accelerates restoration
(via sciencedaily.com) • Twenty-year experiment finds that active replanting beats natural recovery for restoring logged tropical forests. • The higher the diversity of replanted tree species, the more quickly canopy area and biomass recovered. • Results emphasize the importance of preserving biodiversity in pristine forests and restoring it in recovering logged forest.
Published Genome editing: Reducing off-target mutations in DNA
(via sciencedaily.com) Original source Researchers have developed a novel genome editing technique known as NICER, which results in significantly fewer off-target mutations than CRISPR/Cas9 editing. The technique uses a different type of enzyme that makes single-stranded 'nicks' in the DNA. Repair of these nicks is more efficient and accurate than repair of double-strand breaks caused by the current CRISPR/Cas9 editing. This technique represents a novel approach for the treatment of genetic diseases caused by heterozygous mutations.
Published Genetically modified bacteria break down plastics in saltwater
(via sciencedaily.com) Original source Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.
Published Using topology, Researchers advance understanding of how cells organize themselves
(via sciencedaily.com) Original source R esearchers created a machine learning algorithm using computational topology that profiles shapes and spatial patterns in embryos to study how these cells organize themselves into tissue-like architectures. In a new study, they take that system to the next level, opening a path to studying how multiple types of cells assemble themselves.
Published Researchers discover tissue-specific protection against protein aggregation
(via sciencedaily.com) Original source Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail. By understanding how different tissues tackle protein build up, this research could accelerate the identification of ways to protect tissues that are vulnerable to protein build up, possibly tackling both disease-associated protein aggregates and also age-dependent aggregates that accelerate the functional decline of tissues.
Published Lack of maternal care affects development, microbiome and health of wild bees
(via sciencedaily.com) Original source Most wild bees are solitary, but one tiny species of carpenter bees fastidiously cares for and raises their offspring, an act that translates into huge benefits to the developing bee's microbiome, development and health, found researchers. Without maternal care the pathogen load of these developing bees ballooned -- 85 per cent of were fungi, while eight per cent were bacteria -- which can impact their microbiome, a critical component of bee health, as well as their development, immune system and gene expression.
Published From hagfish to membrane: Modeling age-related macular degeneration
(via sciencedaily.com) Original source Researchers have successfully demonstrated that hagfish slime proteins can accurately replicate membranes in the human eye. Scientists were able to properly grow retinal cells on hagfish slime proteins and prove that the protein's behavior changes as the membrane mimics stages of aging and disease.
Published Flu: Interferon-gamma from T follicular helper cells is required to create lung-resident memory B cells
(via sciencedaily.com) Original source During a bout of influenza, B cells interact with other immune cells and then take different paths to defend the body. One path is the B cells that differentiate into lung-resident memory B cells, or lung-BRMs, that are critical for pulmonary immunity. These long-lived, non-circulating lung-BRMs migrate to the lungs from draining lymph nodes and reside there permanently as the first layer of defense that can quickly react to produce antibodies in a future infection.