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Categories: Biology: Developmental, Ecology: Invasive Species

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Findings can open up new avenues for targeted approaches toward therapeutic strategies against the malaria-causing P. falciparum that are aimed at stopping the parasite's life cycle progression and its sexual differentiation, thus blocking the transmission of the parasite into mosquitoes.

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Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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A study on 'canopy soils' on old trees in Costa Rica shows they are important habitats and carbon stores that cannot easily be replaced.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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A new study of cavity-nesting birds in Ecuador shows the influence of deforestation on their habitat and reproductive success. Nest boxes could help.

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Climate impacts such as dry, hot summers reduce the growth and increase the mortality of trees in the Black Forest because they negatively influence the climatic water balance, i.e., the difference between precipitation and potential evapotranspiration. That is the central finding of a long-term study of the influence of climate and climate change on trees in the Black Forest.

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Regulatory genes -- genes that control how other genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study. This contribution is 44% more than expected and much higher than previous studies of regulatory genes in humans. The findings, reported by a team of animal and human geneticists, could improve the efficiency of agricultural breeding programs. The study also helps solve the longstanding mystery of why mammalian genomes contain so much noncoding DNA.

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Researchers combined human and ecological factors to analyze the global scale of non-native tree species invasions. Human activity in hotspots of global trade, such as maritime ports, is linked to an increased likelihood of non-native tree species invasions. However, a high diversity of native tree species can help to curb the intensity of such invasions.

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New research has revealed Australia's iconic grasstrees -- known as 'yaccas' -- play a critical role in protecting wildlife from deadly weather extremes, thereby ensuring their survival. But the grasses themselves are under threat due to back burning, clearing and disease.

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Birds native to the tropical Andes are threatened by increasing agricultural development in the region. A new study combines a meta-analysis of papers on birds across the Andes with five years of fieldwork in Peru, revealing that open farmlands result in up to a 60% decline in the number of species in an area. The study documents how specific species are affected and provides tailored guidance for conservationists trying to protect them.

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Researchers model and map how neurons across the tiny brain of a C. elegans worm encode its behaviors, revealing many new insights about the robustness and flexibility of its nervous system.

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Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures.

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An extremely rare collection of 160-million-year-old sea spider fossils from Southern France are closely related to living species, unlike older fossils of their kind.

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Can you recognize an old friend, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to retain information, but the molecular basis behind this process isn't well understood. New research suggests that complex sugars called glycosaminoglycans might play a major role in the 'plasticity' of the brains of mice and could be used to repair neural connections after injury.

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A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases -- and for those who would like to eat meat, but don't want to kill animals.

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The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a new study.

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Researchers have developed a new algorithm for recovering the 3D refractive index distribution of biological samples that exhibit multiple types of light scattering.