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Categories: Biology: Developmental, Ecology: Invasive Species

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Damage in the human genome can be repaired. But this works better in germ cells, sperm and eggs, than in normal body cells. Responsible for this is the DREAM protein complex, which prevents the activation of all available repair mechanisms. A research team has now shown that normal body cells can also be repaired better once this complex has been deactivated. In the long run, the scientists hope to develop better therapies to prevent cancer and aging-associated diseases.

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Memory B cells play a critical role to provide long-term immunity after a vaccination or infection. Researchers have now described a distinct and novel subset of memory B cells that predict long-lived antibody responses to influenza vaccination in humans. These effector memory B cells appear to be poised for a rapid serum antibody response upon secondary challenge one year later.

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By combining lab experiments and mathematical modelling, researchers have found a way to predict the movement of species that could guide conservation efforts to reconnect fragmented habitats.

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An unusually severe form of toxoplasmosis killed four sea otters and could pose a threat to other marine wildlife and humans, finds a new study.

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A mosquito known only by its scientific name, Culex lactator, is the latest to establish in the Sunshine State, according to a new study.

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Researchers find stem cells use a surprising system for discarding misfolded proteins. This unique pathway could be the key to maintaining long-term health and preventing age-related blood and immune disorders.

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The growing period of hardwood forests in eastern North America has increased by an average of one month over the past century as temperatures have steadily risen, a new study has found.

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Increases in mortality among Douglas-fir in the Klamath Mountains are the result of multiple factors that have the iconic tree in a 'decline spiral' in parts of the region.

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A new study explores a record of birds' diets preserved in their feathers and radio tracking of their movements to find that birds eat far fewer invertebrates in coffee plantations than in forests, suggesting that the disturbance of their ecosystem significantly impacts the birds' dietary options.

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More than 85% of the world's bird, mammal, and amphibian species live in mountains, particularly in forest habitats, but researchers report that these forests are disappearing at an accelerating rate. Globally, we have lost 78.1 million hectares (7.1%) of mountain forest since 2000 -- an area larger than the size of Texas. Much of the loss occurred in tropical biodiversity hotspots, putting increasing pressure on threatened species.

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New research has looked at the long-term environmental impact of different methods to control Japanese knotweed. Different ways of trying to control the invasive species have developed over the years but now, as sustainability becomes increasingly important, understanding the effect of these management methods is vital.This new study examines at the entire life cycle and long-term impacts of different management approaches.

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The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell. It also allows the replacement of used cells from a limited number of 'stem' cells, which then proliferate and specialize. In cancer, however, cell proliferation is no longer controlled and becomes chaotic. Researchers have discovered that, in a healthy individual, certain blood immune cells, the monocytes, also have this ability to proliferate, with the aim to replace tissue macrophages, which are essential for the proper functioning of our body.

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New research shows how human-modified landscapes affect the diets of these marsupial scavengers.

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A cytokinin-mediated, proliferation-based mechanism is involved in the generation and maintenance of cell-type specific tissue boundaries during vascular development in Arabidopsis roots. Specifically, the HANABA-TARANU transcription factor forms a feed-forward loop to cytokinin signaling, which in turn regulates the position and frequency of cell proliferation of proto-vascular cells such that mechanical stress of the surrounding tissues guides growth in an apical-oriented manor, maintaining cell patterning throughout the tissue section.

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The human immunodeficiency virus HIV-1 is able to infect various tissues in humans. Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections. The role of the structure and organization of the host genome in HIV-1 infection is not well understood. Using a cell culture model based on brain immune microglia cells, an international research team has now defined the insertion patterns of HIV-1 in the genome of microglia cells.

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'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism.

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Researchers have now encapsulated the young field of nucleolar DNA damage response (DDR) pathways. A new review highlights six mechanisms by which cells repair DNA damage. By attacking these mechanisms, future applied researchers will be able to trip up cancer's reproduction and growth.

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A new study explores exactly what leads to the generation of Th17 cells -- an important subtype of cells in the intestine -- and uncovers some of the underappreciated molecular players and events that lead to cell differentiation in the gut.

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With the aid of some sea slugs, chemists have discovered that one of the smallest conceivable tweaks to a biomolecule can elicit one of the grandest conceivable consequences: directing the activation of neurons. The team has shown that the orientation of a single amino acid -- in this case, one of dozens found in the neuropeptide of a sea slug -- can dictate the likelihood that the peptide activates one neuron receptor versus another. Because different types of receptors are responsible for different neuronal activities, the finding points to another means by which a brain or nervous system can regulate the labyrinthine, life-sustaining communication among its cells.

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New research finds almost 4000 Australian plant species have not been photographed before in the wild, which may lead to their extinction.