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Categories: Biology: Developmental, Environmental: Wildfires
Published Lab-grown retinas explain why people see colors dogs can't
(via sciencedaily.com) Original source With human retinas grown in a petri dish, researchers discovered how an offshoot of vitamin A generates the specialized cells that enable people to see millions of colors, an ability that dogs, cats, and other mammals do not possess. The findings increase understanding of color blindness, age-related vision loss, and other diseases linked to photoreceptor cells. They also demonstrate how genes instruct the human retina to make specific color-sensing cells, a process scientists thought was controlled by thyroid hormones.
Published Protein complex discovered to control DNA repair
(via sciencedaily.com) Original source The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.
Published Study on lamprey embryos sheds light on the evolutionary origin of vertebrate head
(via sciencedaily.com) Original source Scientists have investigated lamprey embryos using cutting-edge microscopic techniques to reveal interesting insights about vertebrate head evolution, clarifying an unresolved mystery in basic science.
Published Smart skin bacteria are able to secrete and produce molecules to treat acne
(via sciencedaily.com) Original source An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without compromising the homeostasis of the entire skin microbiome.
Published Stranger than friction: A force initiating life
(via sciencedaily.com) Original source As the potter works the spinning wheel, the friction between their hands and the soft clay helps them shape it into all kinds of forms and creations. In a fascinating parallel, sea squirt oocytes (immature egg cells) harness friction within various compartments in their interior to undergo developmental changes after conception.
Published Large-scale mapping of pig genes could pave the way for new human medicines
(via sciencedaily.com) Original source Researchers have carried out complex genetic analyses of hundreds of pigs and humans to identify differences and similarities. This new knowledge can be used to ensure healthier pigs for farmers and can help the pharmaceutical industry breed better laboratory pigs for testing new medicines.
Published Life span increases in mice when specific brain cells are activated
(via sciencedaily.com) Original source A new study identifies, in mice, a critical communication pathway connecting the brain and the body's fat tissue in a feedback loop that appears central to energy production throughout the body. The research suggests that the gradual deterioration of this feedback loop contributes to the increasing health problems that are typical of natural aging.
Published Researchers develop algorithm to determine how cellular 'neighborhoods' function in tissues
(via sciencedaily.com) Original source Researchers have developed a new AI-powered algorithm to help understand how different cells organize themselves into particular tissues and communicate with one another.
Published Advancing the generation of in-vivo chimeric lungs in mice using rat-derived stem cells
(via sciencedaily.com) Original source Creating a functional lung using interspecies chimeric animals is an attractive albeit challenging option for lung transplantation, requiring more research on the viable conditions needed for organ generation. A new study uses reverse-blastocyst complementation and tetraploid-based organ complementation methods to first determine these conditions in lung-deficient mice and then to generate rat-derived lungs in these mice. It provides useful insights on the intrinsic species-specific barriers and factors associated with lung development in interspecies chimeric animals.
Published New roles for autophagy genes in cellular waste management and aging
(via sciencedaily.com) Original source Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. Scientists have now uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins -- and ultimately affect aging.
Published Nematode proteins shed light on infertility
(via sciencedaily.com) Original source Biologists developed a method for illuminating the intricate interactions of the synaptonemal complex in the nematode C. elegans. The authors identified a trio of protein segments that guide chromosomal interactions, and pinpointed the location where they interact with each other. Their novel method uses a technique known as genetic suppressor screening, which can serve as a blueprint for research on large cellular assemblies that resist traditional structural analysis.
Published 'Giant' predator worms more than half a billion years old discovered in North Greenland
(via sciencedaily.com) Original source Fossils of a new group of animal predators have been located in the Early Cambrian Sirius Passet fossil locality in North Greenland. These large worms may be some of the earliest carnivorous animals to have colonized the water column more than 518 million years ago, revealing a past dynasty of predators that scientists didn't know existed.
Published Targeted household cleaning can reduce toxic chemicals post-wildfire
(via sciencedaily.com) Original source Wildfires create compounds called polycyclic aromatic hydrocarbons (PAHs), which are formed in the combustion process at high temperatures. These compounds are highly toxic. New research examined how long harmful chemicals found in wildfire smoke can persist and the most effective ways to remove them with everyday household cleaners.
Published Elusive cytonemes guide neural development, provide signaling 'express route'
(via sciencedaily.com) Original source Discover the first images of cytonemes during mammalian neural development, serving as express routes to establish morphogen gradients and tissue patterning.
Published Western Cascades landscapes in Oregon historically burned more often than previously thought
(via sciencedaily.com) Original source Forests on the west slope of Oregon's Cascade Range experienced fire much more often between 1500 and 1895 than had been previously thought.
Published Big impacts from small changes in cell
(via sciencedaily.com) Original source Tiny things matter -- for instance, one amino acid can completely alter the architecture of the cell. Researchers have now investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin. Actin is found in all living cells where it has a range of important functions -- from muscle contraction to cell signalling and cell shape. This protein comes in two different varieties termed 'isoforms', which are known as gamma actin and beta actin.
Published How jellyfish regenerate functional tentacles in days
(via sciencedaily.com) Original source At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now.
Published New tool unifies single-cell data
(via sciencedaily.com) Original source A new methodology that allows for the categorization and organization of single-cell data has been launched. It can be used to create a harmonized dataset for the study of human health and disease.
Published The future of canine stem cell therapy: unprecedented, painless, and feeder-free
(via sciencedaily.com) Original source Scientists have developed an efficient, non-invasive, and pain-free method to generate canine-induced pluripotent stem cells (iPSCs). They identified six reprogramming genes that can boost canine iPSC generation by 120 times compared to conventional methods using fibroblasts. The iPSCs were created from urine-derived cells without the need for feeder cells, an impossible feat until now. Their findings are expected to advance regenerative medicine and genetic disease research in veterinary medicine.
Published Bugs that help bugs: How environmental microbes boost fruit fly reproduction
(via sciencedaily.com) Original source A research group found that in female fruit flies, microorganisms enhance reproductive function, boosting the number of cells that form eggs and the number of mature eggs. This is done by controlling the release of hormones to speed up cell division in the ovaries, and limiting programmed cell death. These findings could improve reproductive medicine and could aid the development of new methods to enhance fertility.