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Categories: Biology: Developmental, Environmental: Wildfires

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Researchers have developed and demonstrated a new method for high-throughput single-cell sorting that uses stimulated Raman spectroscopy rather than the traditional approach of fluorescence-activated cell sorting. The new approach could offer a label-free, nondestructive way to sort cells for a variety of applications, including microbiology, cancer detection and cell therapy.

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The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name. Researchers have now discovered that the genes regulated by the NSL complex also include genes of the intraciliary transport system. This enables different cell types to form cilia on their surface, which are important for cell communication. The study shows that these genes are 'switched on' by the NSL complex, regardless of whether a particular cell has cilia or not. The researchers found that this class of cilia-associated genes is crucial for the function of podocytes. This is a highly specialized cell type of the kidney that, paradoxically, does not have cilia. These findings have important implications for ciliopathies and kidney disease.

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A bitter taste in the mouth is often a symptom or side effect of illness, which may be the result of how the body reacts to pathogens. A new study sheds light on the mechanisms involved in the complex interplay between taste perception and immune function. Their work also highlights the potential of a sequencing tool for investigating epigenetic mechanisms that affect taste-cell gene expression.

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Researchers have discovered a novel approach for engrafting engineered cells into injured lung tissue. These findings may lead to new ways for treating lung diseases, such as emphysema, pulmonary fibrosis and COVID-19. The two studies describe the methodologies for engineering lung stem cells and transplanting them into injured experimental lungs without immunosuppression.

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Researchers have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

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Regulatory genes -- genes that control how other genes are used -- are responsible for 69% of the heritability of dairy cattle traits such as milk production and fertility, according to a new study. This contribution is 44% more than expected and much higher than previous studies of regulatory genes in humans. The findings, reported by a team of animal and human geneticists, could improve the efficiency of agricultural breeding programs. The study also helps solve the longstanding mystery of why mammalian genomes contain so much noncoding DNA.

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New Yorkers can apparently breathe a sigh of relief, at least for now. Their exposure to the smoke in June 2023 from Canadian wildfires led to only a slightly higher bump in visits to New York City hospital emergency departments for breathing problems or asthma attacks than what is seen on days when pollen counts are high. However, authors of a new study say other possible health effects, such as possible heart attacks and stroke, still need to be investigated.

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Researchers model and map how neurons across the tiny brain of a C. elegans worm encode its behaviors, revealing many new insights about the robustness and flexibility of its nervous system.

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Genetic remnants of viruses that are naturally present in the human genome could affect the development of neurodegenerative diseases. Researchers come to this conclusion on the basis of studies on cell cultures.

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Researchers have developed a new tool, REBURN, that can simulate large forest landscapes and wildfire dynamics over decades or centuries under different wildfire management strategies. The model can simulate the consequences of extinguishing all wildfires regardless of size, which was done for much of the 20th century and has contributed to a rise in large and severe wildfires, or of allowing certain fires to return to uninhabited areas to help create a more 'patchwork' forest structure that can help lessen fire severity. REBURN can also simulate conditions where more benign forest landscape dynamics have fully recovered in an area.

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Research attempts to quantify the value of U.S. property at risk in forested areas exposed to increased ecological disturbance associated with climate change, such as wildfire and tree mortality. Property exposed to such climate risks, especially in California, is project to climb substantially if emission-reduction measures are not taken.

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Can you recognize an old friend, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to retain information, but the molecular basis behind this process isn't well understood. New research suggests that complex sugars called glycosaminoglycans might play a major role in the 'plasticity' of the brains of mice and could be used to repair neural connections after injury.

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A new method allows large quantities of muscle stem cells to be safely obtained in cell culture. This provides a potential for treating patients with muscle diseases -- and for those who would like to eat meat, but don't want to kill animals.

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The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of full-strength signals between neurons, according to a new study.

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Researchers have developed a new algorithm for recovering the 3D refractive index distribution of biological samples that exhibit multiple types of light scattering.

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A mathematical model provides new insights into the distribution of genetic information during bacterial cell division

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Dry lightning can still be disastrous even when conditions aren't so dry, a study has found. These cloud-to-ground strikes during little to no rainfall were previously thought to pose wildfire danger only if occurring with less than 2.5 mm of rain in a day (about 0.10 inches). A new study of lightning-ignited wildfires in the U.S. West found the strikes caused wildfires despite up to 7.7 mm (about 0.3 inches) of precipitation. While still a low amount of rain, the more accurate estimation could help responders detect fires earlier, especially those known as 'holdovers,' which can smolder for many days before exploding into full-blown wildfires.

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No amount of air pollution is good for the brain, but wildfires and the emissions resulting from agriculture and farming in particular may pose especially toxic threats to cognitive health, according to new research.

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An international research team details changes in DNA that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.

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Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.