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Categories: Biology: Developmental, Geoscience: Earthquakes
Published LSH genes associated with defining the shapes of stems, flowers and leaves required for N-fixing root nodules
(via sciencedaily.com) Original source The developmental regulators that confer the identity of N-fixing root nodules belong to a transcription factor family (LSH) more commonly associated with defining the shapes of stems, flowers and leaves.
Published Using computers to design proteins allows researchers to make tunable hydrogels that can form both inside and outside of cells
(via sciencedaily.com) Original source New research demonstrates a new class of hydrogels that can form not just outside cells, but also inside of them. These hydrogels exhibited similar mechanical properties both inside and outside of cells, providing researchers with a new tool to group proteins together inside of cells.
Published DNA particles that mimic viruses hold promise as vaccines
(via sciencedaily.com) Original source Using a DNA-based delivery particle, researchers created a vaccine that can induce a strong antibody response against SARS-CoV-2.
Published 'Genomic time machine' reveals secrets of our DNA
(via sciencedaily.com) Original source Researchers reveal a novel method to uncover bits of our genetic blueprint that come from ancient genetic parasites, offering fresh insights into human evolution and health.
Published How macrophages regulate regenerative healing in spiny mice
(via sciencedaily.com) Original source A team of researchers is delving deeper into the science behind how spiny mice can regenerate lost tissue and using what they learn to trigger regeneration in other types of mice -- advances which one day may be translated into humans. Whereas adult laboratory mice heal injuries with scar tissue, spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body.
Published Cellular scaffolding rewired to make microscopic railways
(via sciencedaily.com) Original source Researchers were able to control the growth of thin, branching networks that support cellular structure and help cells function. The networks, called microtubules, can exert force and precisely transport chemicals at a subcellular level.
Published Researchers pinpoint most likely source of HIV rebound infection
(via sciencedaily.com) Original source Antiretroviral therapy (ART) does an excellent job at suppressing HIV to undetectable levels in the blood. However, small amounts of latent virus hide throughout the body, and when treatment is stopped, it opens the door for the virus to rebound. Researchers identified which tissues SIV, the nonhuman primate version of HIV, reemerges from first, just seven days after ART is stopped.
Published World's first successful embryo transfer in rhinos paves the way for saving the northern white rhinos from extinction
(via sciencedaily.com) Original source Scientists have succeeded in achieving the world's first pregnancy of a rhinoceros after an embryo transfer. The southern white rhino embryo was produced in vitro from collected egg cells and sperm and transferred into a southern white rhino surrogate mother at the Ol Pejeta Conservancy in Kenya on September 24, 2023. The BioRescue team confirmed a pregnancy of 70 days with a well-developed 6.4 cm long male embryo. The successful embryo transfer and pregnancy are a proof of concept and allow to now safely move to the transfer of northern white rhino embryos -- a cornerstone in the mission to save the northern white rhino from extinction.
Published New tool reveals gene behavior in bacteria
(via sciencedaily.com) Original source Researchers showed that the way in which genes are turned on and off as bacteria grow provide clues to their regulation.
Published DNA construction led to unexpected discovery of important cell function
(via sciencedaily.com) Original source Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for understanding how the Notch signalling pathway works and how it is involved in several serious diseases.
Published Key factors in human-made earthquakes
(via sciencedaily.com) Original source Researchers report that the roughness of pre-existing faults and associated stress heterogeneity in geological reservoirs play a key role for causing human-made earthquakes, so-called runaway events. The study combines novel fluid injection experiments under acoustic monitoring performed in GFZ's geomechanical laboratory with numerical modelling results.
Published Study throws our understanding of gene regulation for a loop
(via sciencedaily.com) Original source To function properly, the genetic material is highly organized into loop structures that often bring together widely separated sections of the genome critical to the regulation of gene activity. Scientists now address how these loops can help repress or silence gene activity, with potentially far-reaching effects on human health.
Published Machine learning reveals sources of heterogeneity among cells in our bodies
(via sciencedaily.com) Original source A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of chemotherapy treatments, or set a new paradigm in the study of antibiotic-resistant bacteria.
Published Surprisingly simple model explains how brain cells organize and connect
(via sciencedaily.com) Original source A new study by physicists and neuroscientists describes how connectivity among neurons comes about through general principles of networking and self-organization, rather than the biological features of an individual organism.
Published New map shows where damaging earthquakes are most likely to occur in US
(via sciencedaily.com) Original source Scientists recently revealed the latest National Seismic Hazard Model, showing that nearly 75% of the United States could experience a damaging earthquake, emphasizing seismic hazards span a significant part of the country.
Published Bioinformatics: Researchers develop a new machine learning approach
(via sciencedaily.com) Original source To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.
Published 3D in vitro human atherosclerosis model for high-throughput drug screening
(via sciencedaily.com) Original source A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.
Published Researchers create light-powered yeast, providing insights into evolution, biofuels, cellular aging
(via sciencedaily.com) Original source Researchers have engineered one of the world's first yeast cells able to harness energy from light, expanding our understanding of the evolution of this trait -- and paving the way for advancements in biofuel production and cellular aging.
Published Aging mouse sperm affects MicroRNA, increasing the risk of neurodevelopmental disorders
(via sciencedaily.com) Original source Much is known about the added complication to pregnancy when it comes to the age of the mother, but recent studies show that the age of the father can also heighten the risk of neurodevelopmental disorders. A team of researchers has explored the impacts of paternal aging on microRNAs, the molecules that play a crucial role in regulating gene expression.
Published Lab-grown retinas explain why people see colors dogs can't
(via sciencedaily.com) Original source With human retinas grown in a petri dish, researchers discovered how an offshoot of vitamin A generates the specialized cells that enable people to see millions of colors, an ability that dogs, cats, and other mammals do not possess. The findings increase understanding of color blindness, age-related vision loss, and other diseases linked to photoreceptor cells. They also demonstrate how genes instruct the human retina to make specific color-sensing cells, a process scientists thought was controlled by thyroid hormones.