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Categories: Biology: Developmental, Geoscience: Severe Weather
Published New, holistic way to teach synthetic biology
(via sciencedaily.com) Original source Synthetic biology combines principles from science, engineering and social science, creating emerging technologies such as alternative meats and mRNA vaccines; Deconstructing synthetic biology across scales gives rise to new approach to uniting traditional disciplines; Case studies offer a modular, accessible approach to teaching at different institutions.
Published Climate change and sea level rise pose an acute challenge for cities with combined sewer systems
(via sciencedaily.com) Original source Older coastal cities, like Philadelphia, New York and Boston are at risk of being inundated by untreated sewage during floods. Due in part to the design of their combined sewer systems and in part due to sea level rise, these cities could be facing a growing public health crisis as climate change also drives more extreme precipitation. The group recently published research that modeled the potential extent of the problem in a section of the coastal city of Camden, New Jersey, and the effectiveness of one proposed intervention to help protect these communities.
Published From takeoff to flight, the wiring of a fly's nervous system is mapped
(via sciencedaily.com) Original source Although a fly's motor neurons are few, it performs remarkable aerial and terrestrial feats. A wiring diagram recently created of the motor circuits in the central nervous system of the fruit fly is providing detailed information on how the nerve coordination of leg movements differs from that controlling the wings. Such studies reveal the unexpected complexity of the fly's tiny motor system. They also advance the understanding of how the central nervous system in animals coordinates individual muscles to carry out a variety of behaviors.
Published El Niño forecasts extended to 18 months with innovative physics-based model
(via sciencedaily.com) Original source As more attention is drawn to possible severe weather around the world scientists are looking to improve planning for possible droughts, floods and other scenarios. A team of researchers created a new tool that will allow forecasting of El Nino Southern Oscillation by up to 18 months.
Published Cell division: Before commitment, a very long engagement
(via sciencedaily.com) Original source Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours -- sometimes more than a day -- in a reversible intermediate state, according to a new discovery. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.
Published The on-and-off affair in DNA
(via sciencedaily.com) Original source Researchers have discovered that in thale cresses histone H3 lysine-9 (H3K9) methylation, conventionally thought to be a mark of turning off gene transcription, can also turn on gene expression via the interactions of two other proteins and histone marks. The molecular mechanisms demonstrate that rather than functioning as a simple 'off switch,' H3K9 methylation is more like a 'dimmer switch' that fine-tunes DNA transcription. The discovery suggests there might be similar mechanisms in other organisms, too.
Published Slipping a note to a neighbor: The cellular way
(via sciencedaily.com) Original source Study reveals how drug molecules bind in channels between neighboring cells, changing intercellular communication.
Published Zebrafish reveal how bioelectricity shapes muscle development
(via sciencedaily.com) Original source New research describes how nerve cells and muscle cells communicate through electrical signals during development -- a phenomenon known as bioelectricity. The communication, which takes place via specialized channels between cells, is vital for proper development and behavior. The study identifies specific genes that control the process, and pins down what happens when it goes wrong. The finding offers clues to the genetic origins of muscle disorders in humans.
Published Discovery of vast sex differences in cellular activity has major implications for disease treatment
(via sciencedaily.com) Original source The study reveals vast differences in gene activity within the mitochondria of males compared to females. This is the first study to test effects of all 37 genes in the mitochondrial genome -- genes that copepods and humans share. The study found that males demonstrate more activity across all protein-coding mitochondrial genes than females. Although the study looks at tiny marine organisms called copepods, the findings have weighty implications for human medicine.
Published For many urban residents, it's even hotter than their weather app says
(via sciencedaily.com) Original source There's a strong chance that last week's scorching temperatures were even hotter than reported for those living in underserved urban areas. New research from environmental engineers has shown that citizen science tools used to gauge heat in these urban areas likely understate the problem of heat islands due to a lack of weather stations. The researchers also suggest a statistical method to improve estimates of urban heat.
Published How cells boost gene expression
(via sciencedaily.com) Original source The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.
Published Human activity: A double-edged sword in the face of drought
(via sciencedaily.com) Original source A professor analyzes the conflicting impacts of human activities on extreme spring droughts.
Published Restoring the Great Salt Lake would have environmental justice as well as ecological benefits
(via sciencedaily.com) Original source Inland seas around the world are drying up due to increasing human water use and accelerating climate change, and their desiccation is releasing harmful dust that pollutes the surrounding areas during acute dust storms. Using the Great Salt Lake in Utah as a case study, researchers show that dust exposure was highest among Pacific Islanders and Hispanic people and lower in white people compared to all other racial/ethnic groups, and higher for individuals without a high school diploma. Restoring the lake would benefit everyone in the vicinity by reducing dust exposure, and it would also decrease the disparities in exposure between different racial/ethnic and socioeconomic groups.
Published How to make aging a 'fairer game' for all wormkind
(via sciencedaily.com) Original source Researchers have discovered a new fundamental mechanism governing the rules of ageing in worms. The researchers were able to manipulate the mechanism through genetic interventions which dramatically extend not just the lifespan of the worms, but also their health-span. In other words, trading weak, frail old age with vigorous golden years -- all without altering their diet, environment or other external factors.
Published Hurricane changed 'rules of the game' in monkey society
(via sciencedaily.com) Original source A devastating hurricane transformed a monkey society by changing the pros and cons of interacting with others, new research shows.
Published Large wildfires create weather that favors more fire
(via sciencedaily.com) Original source A new study shows soot from large wildfires in California traps sunlight, making days warmer and drier than they ought to be.
Published Where to put head and tail?
(via sciencedaily.com) Original source Formation of the body axes is a critical part of embryonic development. They guarantee that all body parts end up where they belong and that no ears grow on our backs. The head-tail axis, for example, determines the orientation of the two ends of the body. It was previously assumed that this axis is largely determined by the interplay between the Nodal and BMP signals. However, there appears to be another player in this system, as researchers have now discovered by using an embryo-like model system they developed. In the absence of BMP, the signalling molecule beta-catenin takes on the role of the Nodal antagonist. This new mechanism could be a flexible solution for axis formation in embryos with different shapes.
Published Effective hurricane risk messaging
(via sciencedaily.com) Original source Forecasters can use images in social media to better communicate weather related hazards of hurricanes, according to a pair of new studies.
Published Understanding the Green Sahara's collapse
(via sciencedaily.com) Original source Abrupt shifts within complex systems such as the Earth's climate system are extremely hard to predict. Researchers have now succeeded in developing a new method to anticipate such tipping points in advance. They successfully tested the reliability of their method using one of the most severe abrupt climate changes of the past: the shift of the once-green Sahara into a desert.
Published The genetic 'switches' of bone growth
(via sciencedaily.com) Original source In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.