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Categories: Anthropology: Early Humans, Biology: Developmental

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A new study, which centers on evidence from skulls of a 6-million-year-old fossil ape, Lufengpithecus, offers important clues about the origins of bipedal locomotion courtesy of a novel method: analyzing its bony inner ear region using three-dimensional CT-scanning. The inner ear appears to provide a unique record of the evolutionary history of ape locomotion.

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A team of researchers is delving deeper into the science behind how spiny mice can regenerate lost tissue and using what they learn to trigger regeneration in other types of mice -- advances which one day may be translated into humans. Whereas adult laboratory mice heal injuries with scar tissue, spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body.

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Researchers were able to control the growth of thin, branching networks that support cellular structure and help cells function. The networks, called microtubules, can exert force and precisely transport chemicals at a subcellular level.

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Antiretroviral therapy (ART) does an excellent job at suppressing HIV to undetectable levels in the blood. However, small amounts of latent virus hide throughout the body, and when treatment is stopped, it opens the door for the virus to rebound. Researchers identified which tissues SIV, the nonhuman primate version of HIV, reemerges from first, just seven days after ART is stopped.

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Scientists have succeeded in achieving the world's first pregnancy of a rhinoceros after an embryo transfer. The southern white rhino embryo was produced in vitro from collected egg cells and sperm and transferred into a southern white rhino surrogate mother at the Ol Pejeta Conservancy in Kenya on September 24, 2023. The BioRescue team confirmed a pregnancy of 70 days with a well-developed 6.4 cm long male embryo. The successful embryo transfer and pregnancy are a proof of concept and allow to now safely move to the transfer of northern white rhino embryos -- a cornerstone in the mission to save the northern white rhino from extinction.

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Researchers showed that the way in which genes are turned on and off as bacteria grow provide clues to their regulation.

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Researchers have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for understanding how the Notch signalling pathway works and how it is involved in several serious diseases.

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To function properly, the genetic material is highly organized into loop structures that often bring together widely separated sections of the genome critical to the regulation of gene activity. Scientists now address how these loops can help repress or silence gene activity, with potentially far-reaching effects on human health.

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A team of scientists discovered the secrets of cell variability in our bodies. The findings of this research are expected to have far-reaching effects, such as improvement in the efficacy of chemotherapy treatments, or set a new paradigm in the study of antibiotic-resistant bacteria.

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A new study by physicists and neuroscientists describes how connectivity among neurons comes about through general principles of networking and self-organization, rather than the biological features of an individual organism.

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To combat viruses, bacteria and other pathogens, synthetic biology offers new technological approaches whose performance is being validated in experiments. Researchers applied data integration and artificial intelligence (AI) to develop a machine learning approach that can predict the efficacy of CRISPR technologies more accurately than before.

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A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.

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Researchers have engineered one of the world's first yeast cells able to harness energy from light, expanding our understanding of the evolution of this trait -- and paving the way for advancements in biofuel production and cellular aging.

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Much is known about the added complication to pregnancy when it comes to the age of the mother, but recent studies show that the age of the father can also heighten the risk of neurodevelopmental disorders. A team of researchers has explored the impacts of paternal aging on microRNAs, the molecules that play a crucial role in regulating gene expression.

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With human retinas grown in a petri dish, researchers discovered how an offshoot of vitamin A generates the specialized cells that enable people to see millions of colors, an ability that dogs, cats, and other mammals do not possess. The findings increase understanding of color blindness, age-related vision loss, and other diseases linked to photoreceptor cells. They also demonstrate how genes instruct the human retina to make specific color-sensing cells, a process scientists thought was controlled by thyroid hormones.

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The repair of damage to genetic material (DNA) in the human body is carried out by highly efficient mechanisms that have not yet been fully researched. A scientific team has now discovered a previously unrecognized control point for these processes. This could lead to a new approach for the development of cancer therapies aimed at inhibiting the repair of damaged cancer cells.

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Scientists have investigated lamprey embryos using cutting-edge microscopic techniques to reveal interesting insights about vertebrate head evolution, clarifying an unresolved mystery in basic science.

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An experimental study has shown that a type of skin bacterium can efficiently be engineered to produce a protein to regulate sebum production. This application could treat acne without compromising the homeostasis of the entire skin microbiome.

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As the potter works the spinning wheel, the friction between their hands and the soft clay helps them shape it into all kinds of forms and creations. In a fascinating parallel, sea squirt oocytes (immature egg cells) harness friction within various compartments in their interior to undergo developmental changes after conception.

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Researchers have carried out complex genetic analyses of hundreds of pigs and humans to identify differences and similarities. This new knowledge can be used to ensure healthier pigs for farmers and can help the pharmaceutical industry breed better laboratory pigs for testing new medicines.