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Categories: Anthropology: Early Humans, Biology: Developmental
Published Yeast with an over half synthetic genome is created in the lab
(via sciencedaily.com) Original source Researchers have combined over seven synthetic chromosomes that were made in the lab into a single yeast cell, resulting in a strain with more than 50% synthetic DNA that survives and replicates similarly to wild yeast strains. A global consortium is working to develop the first synthetic eukaryote genome from scratch. The team has now synthesized and debugged all sixteen yeast chromosomes.
Published Scientists take major step towards completing the world's first synthetic yeast
(via sciencedaily.com) Original source A team of Scientists has completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome. The work represents completion of one of the 16 chromosomes of the yeast genome, which is part of the biggest project ever in synthetic biology; the international synthetic yeast genome collaboration. The collaboration, known as 'Sc2.0' has been a 15-year project involving teams from around the world (UK, US, China, Singapore, UK, France and Australia), working together to make synthetic versions of all of yeast's chromosomes. Alongside this paper, another 9 publications are also released today from other teams describing their synthetic chromosomes. The final completion of the genome project -- the largest synthetic genome ever -- is expected next year.
Published Obesity linked to neurodegeneration through insulin resistance
(via sciencedaily.com) Original source Researchers have discovered a link between obesity and neurodegenerative disorders like Alzheimer's disease. Using the common fruit fly, the research shows that a high-sugar diet -- a hallmark of obesity -- causes insulin resistance in the brain, which in turn reduces the ability to remove neuronal debris, thus increasing the risk of neurodegeneration.
Published Video technology could transform how scientists monitor changes in species evolution and development
(via sciencedaily.com) Original source New research combines microscope and video technology to analyze how different species develop, and how changes in the timings of any developments can be tracked. A detailed analysis of the Energy Proxy Traits (EPTs) that result from these processes has provided researchers with the first evidence that traditionally measured timings of developmental events are associated with far broader changes to the full set of an embryo's observable characteristics.
Published Fossils tell tale of last primate to inhabit North America before humans
(via sciencedaily.com) Original source Paleontologists have shed light on the long-standing saga of Ekgmowechashala, based on fossil teeth and jaws found in both Nebraska and China. Ekgmowechashala is the last primate found in the fossil record before humans.
Published Research outlines how sex differences have evolved
(via sciencedaily.com) Original source Researchers have shown that sex differences in animals vary dramatically across species, organs and developmental stages, and evolve quickly at the gene level but slowly at the cell type level.
Published Female sex determining gene identified in mice
(via sciencedaily.com) Original source Researchers have identified a gene which is an early determining factor of ovary development in mice.
Published A known environmental hazard can change the epigenetics of cells
(via sciencedaily.com) Original source An international team of researchers has discovered that formaldehyde, a widely spread pollutant and common metabolite in our body, interferes in the epigenetic programming of the cell. This finding expands the knowledge of formaldehyde, previously considered only as a DNA mutagen, and helps establishing a further link with cancer.
Published Immunology: Dysfunction of mitochondria drives the exhaustion of T cells
(via sciencedaily.com) Original source In the immune system's fight against cancer and infections, the T cells often lose their power. Now immunologists may have found a possible explanation for this phenomenon.
Published New study sheds light on the molecular mechanisms underlying lipid recycling within cells
(via sciencedaily.com) Original source Our understanding of how cells recycle lipids through autophagy -- a form of cellular degradation -- has grown significantly, thanks to a recent study. Using yeast as a model organism, the researchers explored the molecular mechanisms leading to the degradation of the phospholipid bilayers making up the cell membranes. Their findings improve our understanding of cellular degradation processes and related metabolic disorders.
Published First mice engineered to survive COVID-19 like young, healthy humans
(via sciencedaily.com) Original source Researchers have genetically engineered the first mice that get a human-like form of COVID-19, according to a new study.
Published Where is a sea star's head? Maybe just about everywhere
(via sciencedaily.com) Original source A new study that combines genetic and molecular techniques helps solve the riddle of sea star (commonly called starfish) body plans, and how sea stars start life with bilateral body symmetry -- just like humans -- but grow up to be adults with fivefold 'pentaradial' symmetry.
Published Pinpointing HIV immune response
(via sciencedaily.com) Original source New research combining computer modeling and experiments with macaques shows the body's immune system helps control human immunodeficiency virus (HIV) infections largely by suppressing viral production in already infected cells while also killing viral infected cells, but only within a narrow time window at the start of a cell's infection.
Published Maternal microbiota can affect fetal development
(via sciencedaily.com) Original source Significant differences in the gene activity of the fetal intestine, brain and placenta were identified, depending on the microbes in the mother's body and the compounds produced by them. The findings indicate that maternal microbes are important to her offspring's development and health.
Published New Nijmegen method reveals hidden genetic variations
(via sciencedaily.com) Original source Many hidden genetic variations can be detected with Chameleolyser, a new method. The information is already yielding new patient diagnoses and may also lead to the discovery of as yet unknown disease genes.
Published Advanced assisted reproduction in white rhinos is safe and reliable, shows evaluation of procedures
(via sciencedaily.com) Original source The BioRescue project develops and pioneers advanced assisted reproduction technologies (aART) for conservation in the face of the imminent extinction of most rhino species and subspecies. In a new scientific analysis, the team evaluated 65 aART procedures conducted from 2015 to 2022. The evaluation showed that aART is safe for the donor females with no detrimental health effects, and successful in that it yielded 51 embryos.
Published Scientists create special 'telomouse' with human-like telomeres
(via sciencedaily.com) Original source Researchers introduce the 'Telomouse'. By making a subtle genetic alteration in standard lab mice, they've made the mouse telomeres, which protect the chromosome ends, more closely resemble those in humans. The Telomouse model, developed by incorporating a genetic variation from a mouse species with naturally shorter telomeres, provides a valuable resource for in-depth aging and cancer research. This discovery promises to reveal new insights into the genetics of aging and may contribute to enhanced longevity and well-being.
Published Controlling organoids with light
(via sciencedaily.com) Original source Organoids help researchers understand biological processes in health and in disease. It is, however, difficult to influence the way in which they organize themselves into complex tissues. Now a group has found a new way to do so.
Published The genetic heritage of the Denisovans may have left its mark on our mental health
(via sciencedaily.com) Original source A research team has identified the most widespread genetic contribution by Denisovans to date. The study reveals that the genetic variant observed, which affects zinc regulation, could have signified an evolutionary advantage in our ancestors' adaptation to the cold. The study also reveals that this genetic adaptation may have predisposed modern humans to neuropsychiatric disorders.
Published To navigate the world, we all shimmy like these electric fish
(via sciencedaily.com) Original source An electric knifefish shimmies in the water for the same reason a dog sniffs or a human glances around a new place -- to make sense of their surroundings. For the first time, scientists demonstrate that a wide range of organisms, even microbes, perform the same pattern of movements in order to sense the world.