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Categories: Anthropology: Early Humans, Biology: Developmental

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Bone remains found in a Tibetan cave 3,280 m above sea level indicate an ancient group of humans survived here for many millennia.

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The sea worm Platynereis dumerilii is only a few centimeters long but has a remarkable ability: in just a few days, it can regenerate entire parts of its body after an injury or amputation. By focusing more specifically on the mechanisms at play in the regeneration of this worm's tail, a research team has observed that gut cells play a role in the regeneration of the intestine as well as other tissues such as muscle and epidermis.

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Researchers have made a significant advance in understanding how genes are controlled in living organisms. The new study focuses on critical snippets of RNA in the tiny, transparent roundworm Caenorhabditis elegans (C. elegans). The study provides a detailed map of the 3'UTR regions of RNA in C. elegans. 3'UTRs (untranslated regions) are segments of RNA involved in gene regulation.

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Bacteria are experts at evolving resistance to antibiotics. One resistance strategy is to cover their cell walls in sticky and gooey biofilm that antibiotics cannot penetrate. A new discovery could put a stop to this strategy.

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Synthetic biology combines principles from science, engineering and social science, creating emerging technologies such as alternative meats and mRNA vaccines; Deconstructing synthetic biology across scales gives rise to new approach to uniting traditional disciplines; Case studies offer a modular, accessible approach to teaching at different institutions.

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Although a fly's motor neurons are few, it performs remarkable aerial and terrestrial feats. A wiring diagram recently created of the motor circuits in the central nervous system of the fruit fly is providing detailed information on how the nerve coordination of leg movements differs from that controlling the wings. Such studies reveal the unexpected complexity of the fly's tiny motor system. They also advance the understanding of how the central nervous system in animals coordinates individual muscles to carry out a variety of behaviors.

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Before a cell commits fully to the process of dividing itself into two new cells, it may ensure the appropriateness of its commitment by staying for many hours -- sometimes more than a day -- in a reversible intermediate state, according to a new discovery. Their revelation of this fundamental feature of biology includes details of its mechanisms and dynamics, which may inform the development of future therapies targeting cancers and other diseases.

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Researchers have discovered that in thale cresses histone H3 lysine-9 (H3K9) methylation, conventionally thought to be a mark of turning off gene transcription, can also turn on gene expression via the interactions of two other proteins and histone marks. The molecular mechanisms demonstrate that rather than functioning as a simple 'off switch,' H3K9 methylation is more like a 'dimmer switch' that fine-tunes DNA transcription. The discovery suggests there might be similar mechanisms in other organisms, too.

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A new study documents the first case of Down syndrome in Neanderthals and reveals that they were capable of providing altruistic care and support for a vulnerable member of their social group.

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Study reveals how drug molecules bind in channels between neighboring cells, changing intercellular communication.

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New research describes how nerve cells and muscle cells communicate through electrical signals during development -- a phenomenon known as bioelectricity. The communication, which takes place via specialized channels between cells, is vital for proper development and behavior. The study identifies specific genes that control the process, and pins down what happens when it goes wrong. The finding offers clues to the genetic origins of muscle disorders in humans.

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The study reveals vast differences in gene activity within the mitochondria of males compared to females. This is the first study to test effects of all 37 genes in the mitochondrial genome -- genes that copepods and humans share. The study found that males demonstrate more activity across all protein-coding mitochondrial genes than females. Although the study looks at tiny marine organisms called copepods, the findings have weighty implications for human medicine.

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The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins -- yet it exists in large quantities. A research team has now discovered an important function of antisense RNA (asRNA): the researchers found that asRNA acts as a 'superhighway' in cell transport and thus accelerates gene expression.

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Researchers have discovered a new fundamental mechanism governing the rules of ageing in worms. The researchers were able to manipulate the mechanism through genetic interventions which dramatically extend not just the lifespan of the worms, but also their health-span. In other words, trading weak, frail old age with vigorous golden years -- all without altering their diet, environment or other external factors.

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Formation of the body axes is a critical part of embryonic development. They guarantee that all body parts end up where they belong and that no ears grow on our backs. The head-tail axis, for example, determines the orientation of the two ends of the body. It was previously assumed that this axis is largely determined by the interplay between the Nodal and BMP signals. However, there appears to be another player in this system, as researchers have now discovered by using an embryo-like model system they developed. In the absence of BMP, the signalling molecule beta-catenin takes on the role of the Nodal antagonist. This new mechanism could be a flexible solution for axis formation in embryos with different shapes.

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Cumulative culture -- the accumulation of technological modifications and improvements over generations -- allowed humans to adapt to a diversity of environments and challenges. But, it is unclear when cumulative culture first developed during hominin evolution. A new study concludes that humans began to rapidly accumulate technological knowledge through social learning around 600,000 years ago.

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In mammals, only 3% of the genome consists of coding genes which, when transcribed into proteins, ensure the biological functions of the organism and the in-utero development of future individuals. But genes do not function alone. They are controlled by other sequences in the genome, called enhancers, which, like switches, activate or deactivate them as required. A team has now identified and located 2700 enhancers -- among millions of non-coding genetic sequences -- that precisely regulate the genes responsible for bone growth. This discovery sheds light on one of the major factors influencing the size of individuals in adulthood, and explains why their failure could be the cause of certain bone malformations.

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Scientists have unraveled the ancestral history of one of the most iconic birds of prey in the current Iberian fauna: the Bonelli's eagle (Aquila fasciata). The study combines evidence from several disciplines, including palaeontology, genetics and ecology, to answer questions about when and why the Bonelli's eagle, a species primarily found in tropical and subtropical areas, colonized the Mediterranean Basin.

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Goldenrod can perceive other plants nearby without ever touching them, by sensing far-red light ratios reflected off leaves. When goldenrod is eaten by herbivores, it adapts its response based on whether or not another plant is nearby. Is this kind of flexible, real-time, adaptive response a sign of intelligence in plants?

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Researchers have discovered that virus-like nanoparticles can promote the multicellular organization and reproduction of host bacteria. These particles, which are evolutionarily related to phages (viruses that infect bacteria), contain an enzyme that helps shape the multicellular architecture and ultimately enhances morphological differentiation.